Month: November 2022

On April 7, 2021, Hoque, Emdadul Md; Hassan, Mirja Mahamudul Md; Chattopadhyay, Buddhadeb published an article.Product Details of 1073339-22-6 The title of the article was Remarkably Efficient Iridium Catalysts for Directed C(sp2)-H and C(sp3)-H Borylation of Diverse Classes of Substrates. And the article contained the following:

Here we describe the discovery of a new class of C-H borylation catalysts and their use for regioselective C-H borylation of aromatic, heteroaromatic, and aliphatic systems. The new catalysts have Ir-C(thienyl) or Ir-C(furyl) anionic ligands instead of the diamine-type neutral chelating ligands used in the standard C-H borylation conditions. It is reported that the employment of these newly discovered catalysts show excellent reactivity and ortho-selectivity for diverse classes of aromatic substrates with high isolated yields. Moreover, the catalysts proved to be efficient for a wide number of aliphatic substrates for selective C(sp3)-H bond borylations. Heterocyclic mols. are selectively borylated using the inherently elevated reactivity of the C-H bonds. A number of late-stage C-H functionalization have been described using the same catalysts. Furthermore, we show that one of the catalysts could be used even in open air for the C(sp2)-H and C(sp3)-H borylations enabling the method more general. Preliminary mechanistic studies suggest that the active catalytic intermediate is the Ir(bis)boryl complex, and the attached ligand acts as bidentate ligand. Collectively, this study underlines the discovery of new class of C-H borylation catalysts that should find wide application in the context of C-H functionalization chem. The experimental process involved the reaction of 2-(4-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073339-22-6).Product Details of 1073339-22-6

The Article related to directed ch borylation aromatic heterocyclic compound iridium cyclooctadiene catalyst, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Product Details of 1073339-22-6

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Tajuddin, Hazmi; Harrisson, Peter; Bitterlich, Bianca; Collings, Jonathan C.; Sim, Neil; Batsanov, Andrei S.; Cheung, Man Sing; Kawamorita, Soichiro; Maxwell, Aoife C.; Shukla, Lena; Morris, James; Lin, Zhenyang; Marder, Todd B.; Steel, Patrick G. published an article in 2012, the title of the article was Iridium-catalyzed C-H borylation of quinolines and unsymmetrical 1,2-disubstituted benzenes: insights into steric and electronic effects on selectivity.Reference of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane And the article contains the following content:

Borylation of quinolines provides an attractive method for the late-stage functionalization of this important heterocycle. The regiochem. of this reaction is dominated by sterptsic factors but, by undertaking reactions at room temperature, an underlying electronic selectivity becomes apparent, as exemplified by the comparative reactions of 7-halo-2-methylquinoline and 2,7-dimethylquinoline which afford variable amounts of the 5- and 4-borylated products. Similar electronic selectivities are observed for nonsym. 1,2-disubstituted benzenes. The site of borylation can be simply estimated by anal. of the 1H NMR spectrum of the starting material with preferential borylation occurring at the site of the most deshielded sterically accessible H or C atom. Such effects can be linked with C-H acidity. While DFT calculations of the pKa for the C-H bond show good correlation with the observed selectivity, small differences suggest that related alternative, but much more computationally demanding values, such as the M-C bond strength, may be better quant. predictors of selectivity. The experimental process involved the reaction of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1417036-28-2).Reference of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

The Article related to quinoline derivative borylation iridium catalyst regiochem steric electronic effect, mol structure borylated quinoline preparation, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Reference of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Ether – Wikipedia,
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Cheng, Cang; Zuo, Xiang; Tu, Dongdong; Wan, Bin; Zhang, Yanghui published an article in 2021, the title of the article was Palladium-catalyzed diastereoselective cross-coupling of two aryl halides via C-H activation: synthesis of chiral eight-membered nitrogen heterocycles.Category: ethers-buliding-blocks And the article contains the following content:

A method for the synthesis of enantiopure eight-membered nitrogen heterocycles, e.g., I was developed through diastereoselective cross-coupling of 2-iodobiphenyls with 2-bromobenzylamines. The products represented a novel type of chiral scaffold, which feature easy modification and high configurative stability and had the potential to be applied in asym. synthesis. Palladacycles that were formed via the C-H activation of 2-iodobiphenyls should act as the intermediates. The reaction provided a new strategy for the synthesis of medium-sized ring compounds The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Category: ethers-buliding-blocks

The Article related to chiral eight membered nitrogen heterocycle diastereoselective preparation, aryl halide ch activation palladium catalyst cross coupling, Heterocyclic Compounds (One Hetero Atom): Higher-Membered Rings and other aspects.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On June 27, 2022, Bole, Leonie J.; Tortajada, Andreu; Hevia, Eva published an article.HPLC of Formula: 93-04-9 The title of the article was Enhancing Metalating Efficiency of the Sodium Amide NaTMP in Arene Borylation Applications. And the article contained the following:

Though LiTMP (TMP = 2,2,6,6-tetramethylpiperidide) is a commonly used amide, surprisingly the heavier NaTMP has hardly been utilized. Here, by mixing NaTMP with tridentate donor PMDETA (N,N,N’,N”,N”-pentamethyldiethylenetriamine), we provide structural, and mechanistic insights into the sodiation of non-activated arenes (e.g. anisole and benzene). While these reactions are low yielding, adding B(OiPr)3 has a profound effect, not only by intercepting the CAr-Na bond, but also by driving the metalation reaction towards quant. formation of more stabilized sodium aryl boronates. Demonstrating its metalating power, regioselective C2-metalation/borylation of naphthalene has been accomplished contrasting with single-metal based protocols which are unselective and low yielding. Extension to other arenes allows for in situ generation of aryl boronates which can then directly engage in Suzuki-Miyaura couplings, furnishing a range of biaryls in a selective and efficient manner. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).HPLC of Formula: 93-04-9

The Article related to metalation arene sodium amide borylation suzuki coupling preparation biaryl, amide, borylation, metalation, sodium, structural elucidation, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.HPLC of Formula: 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 22, 2015, Saito, Yutaro; Segawa, Yasutomo; Itami, Kenichiro published an article.Category: ethers-buliding-blocks The title of the article was para-C-H Borylation of benzene derivatives by a bulky iridium catalyst. And the article contained the following:

A highly para-selective aromatic C-H borylation has been accomplished. By a new iridium catalyst bearing a bulky diphosphine ligand, Xyl-MeO-BIPHEP, the C-H borylation of monosubstituted benzenes can be affected with para-selectivity up to 91%. This catalytic system is quite different from the usual iridium catalysts that cannot distinguish meta- and para-C-H bonds of monosubstituted benzene derivatives, resulting in the preferred formation of meta-products. The para-selectivity increases with increasing bulkiness of the substituent on the arene, indicating that the regioselectivity of the present reaction is primarily controlled by steric repulsion between substrate and catalyst. Caramiphen, an anticholinergic drug used in the treatment of Parkinson’s disease, was converted into five derivatives via our para-selective borylation. The present [Ir(cod)OH]2/Xyl-MeO-BIPHEP catalyst represents a unique, sterically controlled, para-selective, aromatic C-H borylation system that should find use in streamlined, predictable chem. synthesis and in the rapid discovery and optimization of pharmaceuticals and materials. The experimental process involved the reaction of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1417036-28-2).Category: ethers-buliding-blocks

The Article related to boration monosubstituted benzene para selective iridium biphep catalyst, arylboronic ester preparation para selective boration aromatic substitution, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 21, 2021, Kuleshova, Olena; Asako, Sobi; Ilies, Laurean published an article.Computed Properties of 321-28-8 The title of the article was Ligand-Enabled, Iridium-Catalyzed ortho-Borylation of Fluoroarenes. And the article contained the following:

A terpyridine derivative and an iridium complex catalyze the C-H borylation of a stoichiometric amount of a fluoroarene with high ortho-selectivity and tolerance of functional groups such as bromide, chloride, ester, ketone, amine, and in situ-borylated hydroxyl. Complex drug mols. such as haloperidol can be selectively borylated ortho to the F atom. The terpyridine ligand undergoes rollover cyclometalation to produce an N,N,C-coordinated iridium complex, which may either selectively borylate the fluoroarene by itself or undergo reductive elimination to produce a borylated ligand. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Computed Properties of 321-28-8

The Article related to fluoroarene directed ortho borylation iridium catalyst preparation arylboronic ester, terpyridine iridium complex catalyst directed ortho borylation aryl fluoride, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Computed Properties of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Qiao; Cai, Yun; Hu, Yuanyuan; Jin, Hongwei; Chen, Fener; Liu, Yunkui; Zhou, Bingwei published an article in 2021, the title of the article was Nickel-catalyzed cyclization of 1,7-enynes for the selective synthesis of dihydrocyclobuta[c]quinolin-3-ones and benzo[b]azocin-2-ones.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

A nickel-catalyzed cyclization of N-(o-ethynylaryl)acrylamides for selective syntheses of dihydrocyclobuta[c]quinolin-3-ones I [R1 = Ph, 2-MeOC6H4, 4-ClC6H4, etc.; R2 = H, Me, Ph; R3 = Me, Et, Bn, methoxymethyl; R4 = H, 7-Me, 6-Cl, etc.] and benzo[b]azocin-2-ones II [R5 = Ph, 4-MeC6H4, 3-thienyl, etc.; R6 = H, Me, Ph; R7 = Me, Bn, methoxymethyl; R8 = H, 8-Me, 8-CN, etc.] was reported. The two varied products I and II could be easily obtained by tuning the reaction temperature This reaction featured easy temperature-control, high efficiency and gram-scale synthesis. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to dihydrocyclobutaquinolinone chemoselective preparation, enyne cyclization nickel catalyst, benzoazocinone chemoselective preparation, cyclization enyne nickel catalyst, Heterocyclic Compounds (One Hetero Atom): Higher-Membered Rings and other aspects.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 30, 2021, Liu, Jinguang; Liu, Yuqian; Wang, Anqi; Dai, Zhen; Wang, Rui; Sun, Hui; Strappe, Padraig; Zhou, Zhongkai published an article.Safety of 1,2-Dimethoxybenzene The title of the article was Characteristics of moisture migration and volatile compounds of rice stored under various storage conditions. And the article contained the following:

Yellowing is associated with the changes in rice quality during storage. This study revealed that the increased yellowness of rice was highly associated with the moisture content of rice during storage. The hysteresis loop formed by sorption and desorption curves showed that the water loss of japonica rice was the largest, suggesting the internal structure of japonica rice was more vulnerable to be damaged. The heat enthalpy of rice increased first, and then decreased during yellowing, indicating the changes in the corresponding rice structure. The changes in the moisture migration were monitored by low-field NMR, and the data showed that the content of tightly bound water decreased during yellowing, and the tightly bound water transferred to higher fluidity in medium moisture content (MMC) and higher moisture content (HMC) sample. The concentration of most esters, ketones and alcs. of rice was increased during yellowing in a lower moisture content (LMC) sample. This study revealed that the yellowing process could inhibit the release of some volatiles for MMC and HMC samples. The increased 1,2-dimethoxy-benzene and phenol in HMC sample during yellowing were the characteristic volatiles for the highest yellowed rice samples. This study may highlight the further understanding of rice yellowing mechanism. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Safety of 1,2-Dimethoxybenzene

The Article related to yellowing hysteresis desorption storage japonica, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.Safety of 1,2-Dimethoxybenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 31, 2003, Wang, Y.; Somers, E. B.; Manolache, S.; Denes, F. S.; Wong, A. C. L. published an article.Related Products of 929-37-3 The title of the article was Cold plasma synthesis of poly(ethylene glycol)-like layers on stainless-steel surfaces to reduce attachment and biofilm formation by Listeria monocytogenes. And the article contained the following:

Poly(ethylene glycol) (PEG)-like structures were generated on stainless steel under di(ethylene glycol) vinyl ether (DiEGVE) radio frequency-plasma environments. Electron spectroscopy for chem. anal. and attenuated total reflectance Fourier transform IR spectroscopy indicated a PEG-like deposition, which was stable to cleaning, sanitizing, and storage for up to 2 mo. At. force microscopy and water contact angle anal. indicated that the modified stainless-steel surfaces were less rough and more hydrophilic than the unmodified surfaces. Listeria monocytogenes attachment and biofilm formation on modified surfaces decreased more than 90% compared with the unmodified stainless steel (P < 0.01). DiEGVE cold plasma was demonstrated to be a promising technique to reduce bacterial contamination on surfaces encountered in food-processing environments. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Related Products of 929-37-3

The Article related to cold plasma stainless steel polyethylene glycol listeria biofilm, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.Related Products of 929-37-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Zhenchun; Mei, Xin; Jin, Yuxia; Kim, Eun-Hye; Yang, Ziyin; Tu, Youying published an article in 2014, the title of the article was Optimisation of supercritical carbon dioxide extraction of essential oil of flowers of tea (Camellia sinensis L.) plants and its antioxidative activity.Formula: C7H7FO And the article contains the following content:

BACKGROUNDTo extract natural volatile compounds from tea (Camellia sinensis) flowers without thermal degradation and residue of organic solvents, supercritical fluid extraction (SFE) using carbon dioxide was employed to prepare essential oil of tea flowers in the present study. Four important parameters-pressure, temperature, static extraction time, and dynamic extraction time-were selected as independent variables in the SFE. RESULTSThe optimum extraction conditions were the pressure of 30 MPa, temperature of 50°C, static time of 10 min, and dynamic time of 90 min. Based on gas chromatog.-mass spectrometry anal., 59 compounds, including alkanes (45.4%), esters (10.5%), ketones (7.1%), aldehydes (3.7%), terpenes (3.7%), acids (2.1%), alcs. (1.6%), ethers (1.3%) and others (10.3%) were identified in the essential oil of tea flowers. Moreover, the essential oil of tea flowers showed relatively stronger DPPH radical scavenging activity than essential oils of geranium and peppermint, although its antioxidative activity was weaker than those of essential oil of clove, ascorbic acid, tert-butylhydroquinone, and butylated hydroxyanisole. CONCLUSIONEssential oil of tea flowers using SFE contained many types of volatile compounds and showed considerable DPPH scavenging activity. The information will contribute to the future application of tea flowers as raw materials in health-care food and food flavor industries. © 2013 Society of Chem. Industry. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Formula: C7H7FO

The Article related to camellia essential oil supercritical carbon dioxide extraction, antioxidative activity, essential oil, supercritical carbon dioxide extraction, tea flower, volatile, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.Formula: C7H7FO

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Ether – Wikipedia,
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