On June 27, 2022, Bole, Leonie J.; Tortajada, Andreu; Hevia, Eva published an article.HPLC of Formula: 93-04-9 The title of the article was Enhancing Metalating Efficiency of the Sodium Amide NaTMP in Arene Borylation Applications. And the article contained the following:
Though LiTMP (TMP = 2,2,6,6-tetramethylpiperidide) is a commonly used amide, surprisingly the heavier NaTMP has hardly been utilized. Here, by mixing NaTMP with tridentate donor PMDETA (N,N,N’,N”,N”-pentamethyldiethylenetriamine), we provide structural, and mechanistic insights into the sodiation of non-activated arenes (e.g. anisole and benzene). While these reactions are low yielding, adding B(OiPr)3 has a profound effect, not only by intercepting the CAr-Na bond, but also by driving the metalation reaction towards quant. formation of more stabilized sodium aryl boronates. Demonstrating its metalating power, regioselective C2-metalation/borylation of naphthalene has been accomplished contrasting with single-metal based protocols which are unselective and low yielding. Extension to other arenes allows for in situ generation of aryl boronates which can then directly engage in Suzuki-Miyaura couplings, furnishing a range of biaryls in a selective and efficient manner. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).HPLC of Formula: 93-04-9
The Article related to metalation arene sodium amide borylation suzuki coupling preparation biaryl, amide, borylation, metalation, sodium, structural elucidation, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.HPLC of Formula: 93-04-9
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