Month: November 2022

Synthesis and activity of BNF15 against drug-resistant Mycobacterium tuberculosis was written by Mahmud, Hafij Al;Seo, Hoonhee;Kim, Sukyung;Islam, Imtiazul Md;Sultana, Omme Fatema;Nam, Kung-Woo;Lee, Byung-Eui;Sadu, Venkata S.;Lee, Kee-In;Song, Ho-Yeon. And the article was included in Future Medicinal Chemistry in 2021.Name: 4-Benzyloxyphenol The following contents are mentioned in the article:

Tuberculosis is the leading cause of mortality among infectious diseases worldwide. Finding a new competent anti tubercular therapy is essential. We screened thousands of compounds and evaluated their efficacy against Mycobacterium tuberculosis. Initially, 2- nitronaphtho[2,3-b]benzofuran-6,11-dione was active against M. tuberculosis. Next, among 15 newly synthesized derivatives, BNF15 showed promising effect against all drug-sensitive and drug-resistant M. tuberculosis (MIC: 0.02-0.78 μg/mL). BNF15 effectively killed intracellular M. tuberculosis and nontuberculous mycobacteria. BNF15 exhibited a prolonged post antibiotic effect superior to isoniazid, streptomycin, and ethambutol and synergistic interaction with rifampicin. In acute oral toxicity test, BNF15 did not show toxic effect at a concentration up to 2000 mg/kg. These results highlight the perspective of BNF15 to treat drug-resistant M. tuberculosis. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Name: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and activity of BNF15 against drug-resistant Mycobacterium tuberculosis was written by Mahmud, Hafij Al;Seo, Hoonhee;Kim, Sukyung;Islam, Imtiazul Md;Sultana, Omme Fatema;Nam, Kung-Woo;Lee, Byung-Eui;Sadu, Venkata S.;Lee, Kee-In;Song, Ho-Yeon. And the article was included in Future Medicinal Chemistry in 2021.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

Tuberculosis is the leading cause of mortality among infectious diseases worldwide. Finding a new competent anti tubercular therapy is essential. We screened thousands of compounds and evaluated their efficacy against Mycobacterium tuberculosis. Initially, 2- nitronaphtho[2,3-b]benzofuran-6,11-dione was active against M. tuberculosis. Next, among 15 newly synthesized derivatives, BNF15 showed promising effect against all drug-sensitive and drug-resistant M. tuberculosis (MIC: 0.02-0.78 μg/mL). BNF15 effectively killed intracellular M. tuberculosis and nontuberculous mycobacteria. BNF15 exhibited a prolonged post antibiotic effect superior to isoniazid, streptomycin, and ethambutol and synergistic interaction with rifampicin. In acute oral toxicity test, BNF15 did not show toxic effect at a concentration up to 2000 mg/kg. These results highlight the perspective of BNF15 to treat drug-resistant M. tuberculosis. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Synthetic Route of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Corresponding States Method for Estimation of Upper Flammability Limit Temperature of Chemical Compounds was written by Gharagheizi, Farhad;Ilani-Kashkouli, Poorandokht;Mohammadi, Amir H.. And the article was included in Industrial & Engineering Chemistry Research in 2012.Name: 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

The accuracy and predictability of predictive methods to determine chem. species flammability characteristics are critically important in the chem. industry. This work continued applying the gene expression programming math. strategy to modify existing thermophys. property correlations available in the literature to: optimize the number of independent parameters; amplify the generality; and improve accuracy and predictability. This work presented a simple corresponding states model to predict the upper flammability limit temperature for 1462 organic compounds from 76 chem. families. Correlation parameters included critical temperature and compound acentric factor. Obtained statistical parameters including average absolute relative deviation of results from the DIPPR 801 database values (1.7, 1.8, and 1.7% for training, optimization, and prediction sets, resp.) demonstrated improved accuracy of presented correlations. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Name: 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: 2-(2-(Hexyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photoconductive bent-core liquid crystalline radicals with a paramagnetic polar switchable phase was written by Shivakumar, Kilingaru I.;Pociecha, Damian;Szczytko, Jacek;Kapuscinski, Szymon;Monobe, Hirosato;Kaszynski, Piotr. And the article was included in Journal of Materials Chemistry in 2020.Product Details of 103-16-2 The following contents are mentioned in the article:

A series of self-organizing bent-core derivatives 1[12,n] (I; n = 10, 12, 14, 16) containing a highly π-delocalized stable radical as the central angular structural element, is described. The planarity of the open-shell core permits efficient π-π stacking, which results in the formation of B2 and soft crystalline phases above 100°C. Optical, XRD and dielec. analyses of 1[12,12] indicate that the ground state of the observed B2 phase is polar antiferroelec. of type SmC_AP_A exhibiting tristable electro-optical switching. SQUID and EPR measurements revealed strong antiferromagnetic spin-spin exchange interactions below the isotropic phase, which have been estimated at θ = -46 cm^-1 with the Curie-Weiss law. Transient photoconductivity was observed in the B2 phase with a hole carrier mobility μ_h of 1.4 × 10^-4 cm² V^-1 s^-1. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Product Details of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photoconductive bent-core liquid crystalline radicals with a paramagnetic polar switchable phase was written by Shivakumar, Kilingaru I.;Pociecha, Damian;Szczytko, Jacek;Kapuscinski, Szymon;Monobe, Hirosato;Kaszynski, Piotr. And the article was included in Journal of Materials Chemistry in 2020.Related Products of 103-16-2 The following contents are mentioned in the article:

A series of self-organizing bent-core derivatives 1[12,n] (I; n = 10, 12, 14, 16) containing a highly π-delocalized stable radical as the central angular structural element, is described. The planarity of the open-shell core permits efficient π-π stacking, which results in the formation of B2 and soft crystalline phases above 100°C. Optical, XRD and dielec. analyses of 1[12,12] indicate that the ground state of the observed B2 phase is polar antiferroelec. of type SmC_AP_A exhibiting tristable electro-optical switching. SQUID and EPR measurements revealed strong antiferromagnetic spin-spin exchange interactions below the isotropic phase, which have been estimated at θ = -46 cm^-1 with the Curie-Weiss law. Transient photoconductivity was observed in the B2 phase with a hole carrier mobility μ_h of 1.4 × 10^-4 cm² V^-1 s^-1. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Innovative methodological approach using CIELab and dye screening for chemometric classification and HPLC for the confirmation of dyes in cassava flour: A contribution to product quality control was written by Filgueiras Rebelo de Matos, Marcia;Quenia Muniz Bezerra, Priscilla;Conceicao Argolo Correia, Luciana;Nunes Viola, Denise;de Oliveira Rios, Alessandro;Izabel Druzian, Janice;Larroza Nunes, Itaciara. And the article was included in Food Chemistry in 2021.Formula: C19H16O4 The following contents are mentioned in the article:

A variety of methods for producing cassava flour exist, resulting in very heterogeneous products that exhibit various colors, textures, granulometries, and flavours. To improve its attractiveness to consumers, some producers dye cassava flour with turmeric or tartrazine; however, this practice is illegal in Brazil. In this study, cassava flour samples were collected and evaluated for possible adulteration by the addition of dyes. Flours were analyzed by CIELab and dye screening (paper chromatog. and the turmeric-identification method) and a classification tree was developed using these data. Pos. results for curcuminoid pigments or tartrazine were confirmed by HPLC-DAD or HPLC-UV-Vis, resp. The developed approach is an innovative alternative chemometric-anal. method that facilitates highly practical screening; adulterated cassava flour, a product of great human-food importance, can be identified using CIELab parameters. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Formula: C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C19H16O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors was written by Bandarage, Upul K.;Aronov, Alex M.;Cao, Jingrong;Come, Jon H.;Cottrell, Kevin M.;Davies, Robert J.;Giroux, Simon;Jacobs, Marc;Mahajan, Sudipta;Messersmith, David;Moody, Cameron S.;Swett, Rebecca;Xu, Jinwang. And the article was included in ACS Medicinal Chemistry Letters in 2021.Synthetic Route of C3H9NO The following contents are mentioned in the article:

Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that control a wide variety of cellular functions such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking. PI3Kγ plays a critical role in mediating leukocyte chemotaxis as well as mast cell degranulation, making it a potentially interesting target for autoimmune and inflammatory diseases. We previously disclosed a novel series of PI3Kγ inhibitors derived from a benzothiazole core. The truncation of the benzothiazole core led to the discovery of a structurally diverse alkynyl thiazole series which displayed high PI3Kγ potency and subtype selectivity. Further medicinal chem. optimization of the alkynyl thiazole series led to identification of compounds such as 14 and 32, highly potent, subtype selective, and CNS penetrant PI3Kγ inhibitors. Compound 14 showed robust inhibition of PI3Kγ mediated neutrophil migration in vivo. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Synthetic Route of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Permeation properties of surface modified nanofiltration membrane was written by Park, Hyung-Kiu;Jang, Gyung-Gug;Tak, Tae-Moon. And the article was included in Memburein in 2004.Electric Literature of C10H22O3 The following contents are mentioned in the article:

In this study, we prepared nanofiltration membrane by applying the interfacial polymerization method as a way of manufacturing composite membranes. We have examined the effects of various preparation factors such as monomer concentration and composition, thermal curing condition, post treatment condition. In addition to preparation conditions, we also monitored the effects of operation conditions such as feed solution concentration and operation pressure on the permeation properties of the resulting nanofiltration membrane. We intended to increase the permeation rate of nanofiltration membrane by the enlargement of effective surface area using additives during interfacial polymerization step. With increasing monomer concentration, the membrane permeation rate decreased while maintaining almost constant rejection. With respect to curing conditions, increasing the curing temperature decreased both permeation rate and rejection. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Electric Literature of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Curcumin: An Insight into Molecular Pathways Involved in Anticancer Activity was written by Joshi, Priyanka;Joshi, Sushil;Semwal, Deepak;Bisht, Akansha;Paliwal, Sarvesh;Dwivedi, Jaya;Sharma, Swapnil. And the article was included in Mini-Reviews in Medicinal Chemistry in 2021.Reference of 33171-05-0 The following contents are mentioned in the article:

A review. Curcuma longa has been mentioned in the Indian system of medicine for the management of a wide range of diseases. C. longa and its metabolites like curcumin, ar-turmerone, methylcurcumin, demethoxy-curcumin, and bisdemethoxycurcumin have also been reported to be beneficial in various types of cancer. Curcumin elicits anticancer properties chiefly by triggering apoptotic pathways in cancer cells. The properties are facilitated through diverse signaling pathways viz. pathways mediated by NF-kB, WNT/β-catenin pathway COX-2, LOX, STAT3, prostaglandin E2, phosphorylase kinase, VEGF, AKT, AP1, STAT3, PI3K, Akt, mTOR, ERK5, AP-1, TGF-b, PPARc, EBPa, NLRP3 inflammasome, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4, etc. The present article highlights curcumin biosynthesis, phytochem. and diverse mol. pathways involved in regulating several types of secondary messengers to exhibit anticancer activity in almost all the forms of cancer. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Reference of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sequence-Encoded Macromolecules with Increased Data Storage Capacity through a Thiol-Epoxy Reaction was written by Soete, Matthieu;Mertens, Chiel;Aksakal, Resat;Badi, Nezha;Du Prez, Filip. And the article was included in ACS Macro Letters in 2021.Name: 2-Methoxyethylamine The following contents are mentioned in the article:

Sequence-encoded oligo(thioether urethane)s with two different coding monomers per backbone unit were prepared via a solid phase, two-step iterative protocol based on thiolactone chem. The first step of the synthetic cycle consists of the thiolactone ring opening with a primary amine, whereby the in situ released thiol is immediately reacted with an epoxide. In the second step, the thiolactone group is reinstalled to initiate the next cycle. This strategy allows to introduce two different coding monomers per synthetic cycle, rendering the resulting macromols. especially attractive in the area of (macro)mol. data storage because of their increased data storage capacity. Subsequently, the efficiency of the herein reported synthesis route and the applicability of the dual-encoded sequence-defined macromols. as a potential data storage platform were demonstrated by unraveling the exact monomer order using tandem mass spectrometry techniques. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Name: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Name: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem