Month: December 2022

Alhambra, Cristobal published the artcileDevelopment and SAR of functionally selective allosteric modulators of GABAA receptors, Related Products of ethers-buliding-blocks, the main research area is cinnoline quinoline derivative preparation GABAA receptor selectivity allosteric modulator; structure activity relationship cinnoline quinoline GABAA receptor modulator.

Pos. modulators at the benzodiazepine site of α2- and α3-containing GABAA receptors are believed to be anxiolytic. Through oocyte voltage clamp studies, two series of compounds have been discovered that are pos. modulators at α2-/α3-containing GABAA receptors and that show no functional activity at α1-containing GABAA receptors. Studies to improve this functional selectivity and ultimately deliver clin. candidates are reported. The functional SAR of cinnolines and quinolines that are pos. allosteric modulators of the α2- and α3-containing GABAA receptors, while simultaneously neutral antagonists at α1-containing GABAA receptors, is described. Such functionally selective modulators of GABAA receptors are expected to be useful in the treatment of anxiety and other psychiatric illnesses.

Bioorganic & Medicinal Chemistry published new progress about Allosterism. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Titan, S. M. published the artcileMetabolites related to eGFR: Evaluation of candidate molecules for GFR estimation using untargeted metabolomics, Application In Synthesis of 121-00-6, the main research area is metabolite eGFR untargeted metabolomics; CKD; GFR; Metabolomics.

Metabolomics can be used to identify novel metabolites related to renal function and that could therefore be used for estimating GFR. We evaluated metabolites replicated and related to eGFR in 3 studies (CKD and general population). Metabolomics was performed by GC-MS. The Progredir Cohort (n = 454, class 3 and 4 CKD) was used as the derivation study and adjusted linear regression models on eGFR-CKDEPI were built. Bonferroni correction was applied for selecting metabolites to be independently validated in the Diabetic Nephropathy Study (n = 56, macroalbuminuric DN) and in the Baependi Heart Study (BHS, n = 1145, general population). In the Progredir Cohort, 72 metabolites where associated with eGFR. Of those, 11 were also significantly associated to eGFR in the DN Study and 8 in the BHS. Four metabolites were replicated and significantly associated to eGFR in all 3 studies: D-threitol, myo-inositol, 4-deoxierythronic acid and galacturonic acid. In addition, pseudouridine was strongly correlated to eGFR only in the 2 CKD populations. Our results demonstrate metabolites that are potential biomarkers of renal function: D-threitol, myo-inositol, 4-deoxierythronic acid, galacturonic acid and pseudouridine. Further investigation is needed to determine their performance against otherwise gold-standard methods, most notably among those with normal eGFR.

Clinica Chimica Acta published new progress about Albuminuria. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Application In Synthesis of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kim, Changkyun published the artcileC70-based aqueous-soluble fullerene for the water composition-tolerant performance of eco-friendly polymer solar cells, SDS of cas: 23783-42-8, the main research area is water soluble fullerene polymer solar cell aggregation.

Eco-friendly polymer solar cells (eco-PSCs) based on aqueous-soluble conjugated materials have recently received great research attention. In this work, we report the development of an aqueous-processable C70-based fullerene derivative (PC71BO15) for eco-PSCs processed by water/ethanol co-solvents. The desirable aggregation behavior and enhanced light absorption ability of PC71BO15 have enabled the fabrication of PPDT2FBT-A:PC71BO15-based eco-PSCs with power conversion efficiencies (PCEs) of up to 2.51%, which is the highest value reported to date for aqueous-processed PSCs. These PPDT2FBT-A:PC71BO15 eco-PSCs exhibit significantly higher PCEs than those of the reference PPDT2FBT-A:PC61BO15 devices over all device-processable water/ethanol compositions At the optimal water/ethanol composition (volume/volume = 15 : 85), the PCE of the PPDT2FBT-A:PC71BO15 eco-PSCs is 73% higher than that of the PC61BO15-based counterparts, as a result of enhanced light absorption. Importantly, the PC71BO15-based eco-PSCs show much higher tolerance in their PCEs to the water/ethanol composition For example, the PCEs of the PPDT2FBT-A : PC71BO15 eco-PSCs at a 30 : 70 water/ethanol ratio maintain 89% of the optimal performance at a 15 : 85 ratio, whereas the PC61BO15-based devices only maintain 45%. This large difference in terms of water-tolerant behavior is mainly related to the different aggregation behaviors between PC71BO15 and PC61BO15 in blend films, which are carefully investigated using elec., optical and morphol. characterizations. This high water composition-tolerance affords an excellent reproducibility of the PC71BO15-based eco-PSCs with eco/human-friendly aqueous processing under ambient conditions.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Aggregation. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, SDS of cas: 23783-42-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mandal, Subhankar published the artcileTransition Metal Phthalocyanines as Redox Mediators in Li-O2 Batteries: A Combined Experimental and Theoretical Study of the Influence of 3d Electrons in Redox Mediation, Application of 2,5,8,11,14-Pentaoxapentadecane, the main research area is phthalocyanines lithium oxygen battery redox mediator transition metal; DFT calculations; GITT; Li−oxygen battery; electrochemistry of transition-metal phthalocyanines; impedance; reaction mechanism of ORR and OER; redox mediator.

Redox mediation is an innovative strategy for ensuring efficient energy harvesting from metal-oxygen systems. This work presents a systematic exploratory anal. of first-row transition-metal phthalocyanines as solution-state redox mediators for lithium-oxygen batteries. Our findings, based on experiment and theory, convincingly demonstrate that d5 (Mn), d7 (Co), and d8 (Ni) configurations function better compared to d6 (Fe) and d9 (Cu) in redox mediation of the discharge step. The d10 configuration (Zn) and non-d analogs (Mg) do not show any redox mediation because of the inability of binding with oxygen. The solution-state discharge product, transition-metal bound Li2O2, undergoes dissociation and oxidation in the charging step of the battery, thus confirming a bifunctional redox mediation. Apart from the reaction pathways predicted based on thermodn. considerations, d. functional theory calculations also reveal interesting effects of electrochem. perturbation on the redox mediation mechanisms and the role of the transition-metal center.

ACS Applied Materials & Interfaces published new progress about Aggregation. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Application of 2,5,8,11,14-Pentaoxapentadecane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Russell, D. H. published the artcileThe chemistry of C6H6O radical cations: a study of rearrangement reactions of halogen substituted ethyl phenyl ethers, Recommanded Product: (2-Chloroethoxy)benzene, the main research area is mass spectra phenoxyethyl halide; phenol ion mass spectra; cyclohexadienone ion mass spectra; rearrangement ethyl phenyl ether.

Exptl. data are reported on the rearrangement of phenoxyethyl halides to give [C6H6O]•+ (I) and the results compared with previous data. Determination of the metastable kinetic-energy release for mol. ions which decompose at low energy indicated that I formation occurs via competitive 1,2- and 1,3-H shifts from the alkyl C to O, followed by rate-determining C-O bond cleavage. For more highly activated mol. ions, rearrangement involves transfer of the alkyl H to the ortho position of the ring via a rate-determining 1,5-shift, followed by a 1,3-H shift from the o-methylene group to O and rapid C-O bond cleavage. More highly activated mol. ions produce I, which can undergo metastable decomposition to lose CO; kinetic-energy measurements for the latter reaction indicated that the majority of these I ions were also formed as PhOH ions.

Organic Mass Spectrometry published new progress about Mass spectra. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Recommanded Product: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pellegrino, Anna L. published the artcileMultifunctional “”Dy(hfa)3•glyme”” adducts: Synthesis and magnetic/luminescent behaviour, Computed Properties of 143-24-8, the main research area is multifunctional dysprosium hexafluoroacetylacetone glyme adduct preparation magnetic behavior luminescence.

Dysprosium β-diketonate compounds have recently gained a lot of attention due to their intriguing multifunctional properties. In this paper, a series of “”Dy(hfa)3•glyme”” adducts have been prepared through a one-pot reaction, in dichloromethane, from dysprosium(III) acetate monohydrate, hexafluoroacetylacetone and glyme [Hhfa = 1,1,1,5,5,5-hexafluoroacetylacetone, glyme = bis-(2-methoxyethyl)ether, 2,5,8,11-tetraoxadodecane, 2,5,8,11,14-pentaoxapentadecane]. Based on the length of the polyether, various coordination frameworks have been obtained going from a mononuclear [Dy(hfa)3•diglyme] adduct, to a polymeric chain system for the [Dy(hfa)3•2H2O•triglyme], and an ionic structure for the [Dy(hfa)2•tetraglyme]+[Dy(hfa)4]-. The relationship between the coordination framework in the “”Dy(hfa)3•glyme”” series and the magnetic and luminescent properties has been deeply investigated.

Inorganica Chimica Acta published new progress about Luminescence. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Computed Properties of 143-24-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Oyedeji, Ajibola Bamikole published the artcileMetabolite data of germinated Bambara groundnut flour and starch extracted with two different solvents, Product Details of C10H22O5, the main research area is germinated Bambara groundnut flour starch metabolite solvent extraction; Bambara groundnut; GC-HRTOF-MS; Germination; Metabolites; Solvent extraction.

The data presented in this study represents the profile of metabolites of germinated Bambara groundnut flour (GBF) and starch (GBS) extracted using two different extraction solvents. Bambara groundnuts obtained from a local agro market in Minna, Niger State, Nigeria were germinated at 28 ± 1°C for 24, 48 and 72 h, dried and then processed into flour and starch. Raw Bambara groundnuts (0 h) were also processed into flour and starch and served as controls. Samples at the different germination times were extracted using methanol/water (80:20vol./volume) and acetonitrile/methanol/water (40:40:20 volume/volume/v), concentrated, reconstituted and analyzed on a gas chromatog.-high resolution time of flight-mass spectrometer (GC-HRTOF-MS). Data obtained were classified into compound groups such as acids, alcs., cyclic compounds, esters, ketones, phytosterols, vitamins and many others, and their characteristics such as the retention time, observed mass, mol. formular and mean peak areas were reported. These data represent the collection of metabolites in GBF and GBS and may be useful for the identification and utilization of functional compounds in foods.

Data in Brief published new progress about Food science. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Product Details of C10H22O5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kitada, Atsushi published the artcileGlyme-lithium bis(trifluoromethylsulfonyl)amide superconcentrated electrolytes: salt addition to solvate ionic liquids lowers ionicity but liberates lithium ions, Recommanded Product: 2,5,8,11,14-Pentaoxapentadecane, the main research area is glyme lithium trifluoromethylsulfonyl amide superconcentrated electrolytes solvate ionic liquid.

Solvate ionic liquids (ILs) such as binary equimolar mixtures of glymes (ethyleneglycol-dimethylether or CH3(OCH2CH2)nOCH3) and lithium bis(trifluoromethylsulfonyl)amide (LiTf2N; Tf = SO2CF3) are known to show identical self-diffusion coefficients for glymes and Li+ ions. Here, we report that the addition of LiTf2N to the solvate ILs drastically changes their electrolyte properties. When the lithium salts are added to give the super-concentrated electrolytes with [O]/[Li+] = 3 (molar ratio of ether oxygen to Li+), ligand exchange or hopping conduction of Li+ takes place for triglyme (G3; n = 3) and tetraglyme (G4; n = 4). In addition, the Li+ transference number tLi+(EC), electrochem. measured under anion blocking conditions, increases about 3-6 times compared with the solvate ILs. Consequently, segmental motion of glymes apparently affects the transport properties even for the shorter G3 in the super-concentrated region. The relationship between the coordination structure and the transport properties are also discussed as a function of ionicity, the extent of the contribution of self-diffusion to the actual ion conduction. Plots vs ionicity demonstrate that a clear line can be drawn between the solvate ILs and the super-concentrated electrolytes.

Journal of the Electrochemical Society published new progress about Electrolytes. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Recommanded Product: 2,5,8,11,14-Pentaoxapentadecane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Qi published the artcileChloride Ion as Redox Mediator in Reducing Charge Overpotential of Aprotic Lithium-Oxygen Batteries, Recommanded Product: 2,5,8,11,14-Pentaoxapentadecane, the main research area is chloride ion lithium oxygen battery redox mediator reducing charge.

The aprotic lithium-oxygen (Li-O2) battery with a high theor. energy d. has been considered as a promising candidate for next-generation energy storage devices. However, the formation of insulating Li2O2 products is a major obstacle for realizing the high energy efficiency and long cycle life. Here, we report a new Cl-/Cl3- redox mediator to reduce the charge overpotential by a facile introduction of chloride ion (Cl-) additives into the organic electrolyte. The redox mediator can effectively promote the formation of the LiOH discharge product, and facilitate efficient LiOH decomposition Therefore, the cell with the Cl- additives possesses a significantly low charge overpotential of 0.29 V, an extended cycle life (up to 71 cycles) at a rate of 500 mA g-1 with a fixed capacity of 500 mAh g-1, and an enhanced rate capability. This study offers an effective approach to modulate discharge products from Li2O2 to LiOH and provides new insights toward the role of redox mediators through the addition of Cl- in Li-O2 battery systems.

Batteries & Supercaps published new progress about Electrolytes. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Recommanded Product: 2,5,8,11,14-Pentaoxapentadecane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ma, Yijia published the artcileRecovery of Hydrogen and Sulfur by Electrolysis of Ionized H2S in an Amine-Containing Organic Electrolyte with Highly Temperature-Dependent Sulfur Solubility, HPLC of Formula: 143-24-8, the main research area is recovery hydrogen sulfur electrolysis ionization hydrogen sulfide.

Abundant hydrogen sulfide (H2S) from nature and industry has been considered a harmful substance. However, it is a potential resource if valuable H2 and elemental sulfur can be recovered from H2S. Herein, a new organic electrolyte system was constructed for H2S direct electrolysis using tetraethylene glycol di-Me ether as the solvent, ionic liquid [C3OHmim]BF4 as the supporting electrolyte, and monoethanolamine (MEA) as the absorbent for H2S. The as-prepared electrolyte was found useful as highly temperature-dependent on the sulfur solubility electrolyte with catalytic effects of sorbent MEA, conducive to solving passivation problems caused by sulfur adhesion in direct electrolysis of H2S and sulfur recovery in indirect electrolysis. Moreover, the as-obtained organic electrolyte showed certain stability with Faraday efficiency of H2 generated after three heating-electrolysis-cooling cycles, reaching 89%. In summary, the as-obtained electrolyte looks promising for efficient and continuous electrolysis of H2S.

Energy & Fuels published new progress about Electrolysis. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, HPLC of Formula: 143-24-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem