Alhambra, Cristobal published the artcileDevelopment and SAR of functionally selective allosteric modulators of GABAA receptors, Related Products of ethers-buliding-blocks, the main research area is cinnoline quinoline derivative preparation GABAA receptor selectivity allosteric modulator; structure activity relationship cinnoline quinoline GABAA receptor modulator.
Pos. modulators at the benzodiazepine site of α2- and α3-containing GABAA receptors are believed to be anxiolytic. Through oocyte voltage clamp studies, two series of compounds have been discovered that are pos. modulators at α2-/α3-containing GABAA receptors and that show no functional activity at α1-containing GABAA receptors. Studies to improve this functional selectivity and ultimately deliver clin. candidates are reported. The functional SAR of cinnolines and quinolines that are pos. allosteric modulators of the α2- and α3-containing GABAA receptors, while simultaneously neutral antagonists at α1-containing GABAA receptors, is described. Such functionally selective modulators of GABAA receptors are expected to be useful in the treatment of anxiety and other psychiatric illnesses.
Bioorganic & Medicinal Chemistry published new progress about Allosterism. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Related Products of ethers-buliding-blocks.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem