Category: 2062-98-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6F12O2

In a three-port glass reaction flask with a stirring and condenser in a volume of 0.25L,First add 80g of dioxane, 10g of sodium borohydride, stir and mix.After heating to 50 C, 83 g of perfluoro-2-methyl-3-oxa-hexanoyl fluoride was added dropwise, and the reaction was continued for 2 hours after the addition, and the material was distilled off after the reaction.The crude material was collected by freezing to obtain 96 g. The content of 2-perfluoropropoxy-2,3,3,3-tetrafluoropropanol in the crude material was 75%, and the product yield was 91%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2062-98-8.

Reference:
Patent; Zhejiang Lantian Environmental Protection Gao Technology Co., Ltd.; Sinochem Lantian Group Co., Ltd.; Han Guoqing; Xiang Wenqin; Chen Mingyan; Sheng Nan; (5 pag.)CN108264451; (2018); A;,
Ether – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, A new synthetic method of this compound is introduced below., Quality Control of Perfluoro(2-methyl-3-oxahexanoyl) fluoride

EXAMPLE 1; Example of production of monomer (1M); EXAMPLE 1-1: Esterification reaction; [] 2-Tetrahydrofurfuryl alcohol (20 g) and (CH3CH2)3N (21.8 g) were put in a flask and stirred under cooling with ice. While keeping the temperature in the flask to at most 10C, FCOCF(CF3)OCF2CF2CF3 (71.5 g) was dropwise added over a period of 1 hour. After completion of the dropwise addition, stirring was further carried out at 25C for 2 hours. Then, while keeping the temperature in the flask to at most 15C, water (50 mL) was added to obtain a reaction liquid which was separated into two layers. The reaction liquid was separated, and the lower layer was washed with water (50 mL) twice and dried over magnesium sulfate, followed by filtration to obtain a crude liquid. By distillation under reduced pressure, an aimed ester compound (66.3 g) was obtained as a fraction of 88 to 89C/2.7 kPa (absolute pressure). The GC purity was 98%. Formation of compound (A-20) was confirmed by NMR analysis. 1H-NMR (300.4 MHz, CDCl3, TMS) delta (ppm) : 1.60 to 1.73 (m, 1H), 1.86 to 2.10 (m,3H), 3.76 to 3.91 (m,2H), 4.14 to 4.22 (m, 1H), 4.28 to 4.47 (m,2H). 19F-NMR (282.7 MHz, CDCl3, CFCl3) delta (ppm): -79.9 (1F), -81.3 (3F), -82.1 (3F), -86.4 (1F), -129.5 (2F), -131.5 (1F).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ASAHI GLASS COMPANY LTD.; EP1548014; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, A new synthetic method of this compound is introduced below., Computed Properties of C6F12O2

A mixture of ethanolamine (13 g, 28 mmol) and ether (30 mL) was cooled to 15C. Perfluoro-2-methyl-3-oxahexanoyl fluoride (33 g in ether 50 mL) was added dropwise to keep the reaction temperature below 25C. After the addition, the reaction mixture was stirred at room temperature for one hour. The solid was removed by filtration and the filtrate was washed with hydrochloric acid (0.5N, 30 mL), water (2 times 30 mL), sodium hydrogen carbonate solution (0.5N, 20 mL), water (30 mL), and sodium chloride solution (saturated, 20 mL). It was then concentrated and dried in vacuum over night at room temperature to give a white solid 35 g, yield 95%. The product was analyzed using ^HNMR and the structure confirmed as is N-(perfluoro-2-methyl-3-oxahexanoyl)-2-aminoethanol, C3F7OCF(CF3)CONHCH2CH2OH.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; MURPHY, Peter, Michael; HEWAT, Tracy; WO2010/2623; (2010); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 2062-98-8,Some common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the first step, the fluoroalkyl alcohol was prepared from 2-trifluoromethyl-3-oxa-2,4,4,5,5,6,6,6-octafluorohexanoyl fluoride (i.e. HFPO dimer, commercially available from DuPont). In a reaction flask equipped with condenser and temperature probe was charged LiAlH4 (13.5 g, 0.355 moles) and 500 ml ether solvent and the contents cooled to 0 C. (NaBH4 may be employed in place of LiAlH4). HFPO-dimer (149.4 g, 0.45 moles) was added slowly and the reaction flask contents temperature was controlled at <10 C. with external cooling. After the addition was completed, the reaction mixture was stirred for 2-3 hours at 5-10 C. The reaction mixture was slowly transferred into a 400 ml 6 N HCl/500 mL ice water mixture and the ether layer was separated. The bottom layer was extracted with 200 mL ether (twice). The ether layers were combined, dried over magnesium sulfate, and then distilled to give the fluoroalcohol 2-trifluoromethyl-3-oxa-2,4,4,5,5,6,6,6-octafluorohexane-1-ol (HFPO dimer alcohol) as a clear, colorless liquid, Bp. 112-114 C. Yield: 127 grams (89%).1H-NMR (400 MHz, acetone-d6): delta4.30 (m); 19F-NMR (376.89 MHz, acetone-d6): -80.5 to -82.5 (m, 8F), -129.4 (m, 2F), -134.6 (dm, 1F). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Perfluoro(2-methyl-3-oxahexanoyl) fluoride, its application will become more common. Reference:
Patent; DUPONT PERFORMANCE ELASTOMERS LLC; US2011/257423; (2011); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2062-98-8

In a four-necked flask equipped with a stirrer, a thermometer, a dropping funnel, and a reflux condenser (anhydrous calcium chloride at the top),Add 1,3-dimethyl-1,3,5-triazine (2.76 g, 24 mmol)And dichloromethane (30 mL),After stirring to dissolve, add triethylamine (3.25mL, 26mmol) and cool to 0 C.Was added dropwise with stirring hexafluoropropylene oxide dimer (6.64g, 20mmol),After 1 hour, the addition was completed. After the addition, the reaction was stirred at 0 C for 3 hours.The reaction mixture was washed with 10% sodium hydroxide solution (50 mL) and separated. The organic layer was washed with water, dried over anhydrous sodium sulfate, and the solvent was spin-dried.The residue was separated and purified by column chromatography [dichloromethane / methanol (v / v) = 20/1],7.86 g of a colorless transparent liquid fluorinated intermediate I-1 were obtained,Yield: 92%.

The synthetic route of 2062-98-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ruyuan Dongyang Guangfu Co., Ltd.; Li Yitao; Lan Xiaobin; Hou Qinqing; Yang Feng; Jia Yuan; Cheng Zhen; (9 pag.)CN110818650; (2020); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 2062-98-8, A common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The methyl perfluoroalkyl ether carboxylate was prepared by esterfication of perfluorinated ether acid fluoride with methanol. A mixed solution of 41.11 g anhydrous triethylamine (0.40 mol) in 47.5 g anhydrous methanol (1.48 mol) was added dropwise into 185 g perfluoro-2,5-dimethyl-3,6-dioxa-nonanoic acid fluoride (0.37 mol) in a dry three-neck flask under agitation over a period of 2 h at 0 C. The mixture was agitated for another 4 h and the temperature of reaction mass was maintained at room temperature. Subsequently, the reaction mixture was poured into a separating funnel. The fluorocarbon layer was washed with sodium bicarbonate solution and dried over anhydrous sodium sulfate to obtain the crude product. The crude product was distilled to give 178.43 g methyl perfluoro-2,5-dimethyl-3,6-dioxa-nonanoate (yield 94%) boiling at 145 C at 760 mmHg. IR: 2969,1792, 1290, 1237, 1145, 1040, 994 cm-1. 1H-NMR (500 MHz, CDCl3): delta 3.99 (3H, s, CH3). 13C-NMR (125 MHz, CDCl3): delta 54.60 (-CH3-).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Shi, Xiang; Shi, Hongxin; Wu, Hongke; Shen, HaiMin; Research on Chemical Intermediates; vol. 44; 9; (2018); p. 5091 – 5105;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2062-98-8 as follows. Computed Properties of C6F12O2

General procedure: To a magnetic stirred solution of 15.6 g triethylamine (0.15 mol) and 10.10 g allyl alcohol (0.17 mol) in anhydrous chloroform (150 mL) in a dry three-neck flask, 74.90 g perfluoro-2,5-dimethyl-3,6-dioxa-nonanoyl fluoride (0.15 mol) were added dropwise over a period of 3 h under agitation at 0 C. The reaction mixture was stirred for a further 12 h, with the temperature of reaction mass being maintained at room temperature. Distilled water was added to extract the triethylammonium fluoride and the unreacted allyl alcohol at the end of the reaction. The chloroform layer was dried over anhydrous sodium sulfate, and the major portion of the chloroform was distilled off in the vacuum of a water-jet pump over water. Additionally, the crude product was obtained and distilled under reduced pressure to give the pure product.

According to the analysis of related databases, 2062-98-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shi, Xiang; Shi, Hongxin; Wu, Hongke; Shen, HaiMin; Research on Chemical Intermediates; vol. 44; 9; (2018); p. 5091 – 5105;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 2062-98-8,Some common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the implementation of the example 1 on the basis of the, to amplify production test: the full the fluorine is positive n-propyl vinyl ether (PPVE) 1 kg, hexafluoropropylene oxide dimer 1.5 kg, cesium fluoride 120g and diethylene glycol dimethyl ether 2.6L adding 10L in the reactor, the temperature is increased to 95 C, stirring for 2 hours, the reaction pressure will not change the observation, cooling, opening the reaction kettle, separating out the lower liquid product distillation is C11 the re-compounding process 1.95 kg, yield is 87%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Perfluoro(2-methyl-3-oxahexanoyl) fluoride, its application will become more common.

Reference:
Patent; Tianjin Changlu Chemical New Material Co., Ltd; Zhang, Zhijun; Zhao, Xinghua; Xu, Yashuo; Wang, Bo; Xiao, Shan; (5 pag.)CN105503552; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 2062-98-8, These common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 11 A mixture of ethanolamine (13 g, 28 mmole) and ether (30 mL) was cooled to 15 C. Perfluoro-2-methyl-3-oxahexanoyl fluoride (33 g in ether 50 mL) was added dropwise to keep the reaction temperature below 25 C. After the addition, the reaction mixture was stirred at room temperature for one hour. The solid was removed by filtration and the filtrate was washed with hydrochloric acid (0.5N, 30 mL), water (2 times 30 mL), sodium hydrogen carbonate solution (0.5N, 20 mL), water (30 mL), and sodium chloride solution (saturated, 20 mL). It was then concentrated and dried in vacuum over night at room temperature to give a white solid 35 g, yield 95%. H NMR (CDCl3) 1.67 (br s, 1H), 3.57 (m, 2H), 3.80 (t, J=5 Hz, 2H), 6.91 (br s, 1H) ppm. F NMR (CDCl3) -81.2 (dm, J=148 Hz, 1F), -81.7 (t, J=7 Hz, 3F), -82.7 (d, J=3 Hz, 3F), -85.2 (dm, J=148 Hz, 1F), -130.1 (s, 2F), -133.2 (m, 1F) ppm. The product is N-(perfluoro-2-methyl-3-oxahexanoyl)-2-aminoethanol. A 250-mL flask was charged with triethylamine (8.2 g), THF (80 mL), and N-(perfluoro-2-methyl-3-oxo-hexanoyl)-2-aminoethanol (25 g). Methacryloyl chloride (8.44 g in tetrahydrofuran, 20 mL) was added dropwise to the above mixture at 5 C. The mixture was stirred at room temperature overnight. The reaction mixture was poured into water (200 mL) and two layers were formed. The aqueous layer (top layer) was extracted with methylene chloride (five time 50 mL). The combined methylene chloride extracts and original organic layer were washed with water (six times 60 mL), neutralized with dilute hydrochloric acid (0.5N), dried over anhydrous sodium sulfate, concentrated and dried on vacuum to give a oil, N-(perfluoro-2-methyl-3-oxahexanoyl)-2-aminoethyl methacrylate (27.06 g), yield 92%. H NMR (CDCl3) 1.94 (m, 3H), 3.72 (m, 2H), 4.33 (m, 2H), 5.63 (m, 1H), 6.12 (m, 1H), 6.88 (br s, 1H) ppm. F NMR (CDCl3) -81.2 (dm, J=148 Hz, 1F), -81.7 (t, J=7 Hz, 3F), -82.7 (d, J=3 Hz, 3F), -85.2 (dm, J=148 Hz, 1F), -130.1 (s, 2F), -133.4 (m, 1F) ppm.

Statistics shows that Perfluoro(2-methyl-3-oxahexanoyl) fluoride is playing an increasingly important role. we look forward to future research findings about 2062-98-8.

Application of 2062-98-8, A common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 16 Sodium perfluoro-2-methyl-3-oxahexanoate The procedure of Example 1 was followed using perfluoro-2-methyl-3-oxahexanoyl fluoride (16.6 g, 50 mmol), sodium trimethylsilanolate (5.6 g, 50 mmol), dry o-dichlorobenzene (200 mL), and 1 h at room temperature followed by rapid heating to 150. Sodium perfluoro-2-methyl-3-oxahexanoate (13.6 g, 77% yield) was isolated as a white solid: The 19 F NMR data were the same as reported in Example 15.

The synthetic route of 2062-98-8 has been constantly updated, and we look forward to future research findings.