Synthetic Route of 2062-98-8,Some common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In the first step, the fluoroalkyl alcohol was prepared from 2-trifluoromethyl-3-oxa-2,4,4,5,5,6,6,6-octafluorohexanoyl fluoride (i.e. HFPO dimer, commercially available from DuPont). In a reaction flask equipped with condenser and temperature probe was charged LiAlH4 (13.5 g, 0.355 moles) and 500 ml ether solvent and the contents cooled to 0 C. (NaBH4 may be employed in place of LiAlH4). HFPO-dimer (149.4 g, 0.45 moles) was added slowly and the reaction flask contents temperature was controlled at <10 C. with external cooling. After the addition was completed, the reaction mixture was stirred for 2-3 hours at 5-10 C. The reaction mixture was slowly transferred into a 400 ml 6 N HCl/500 mL ice water mixture and the ether layer was separated. The bottom layer was extracted with 200 mL ether (twice). The ether layers were combined, dried over magnesium sulfate, and then distilled to give the fluoroalcohol 2-trifluoromethyl-3-oxa-2,4,4,5,5,6,6,6-octafluorohexane-1-ol (HFPO dimer alcohol) as a clear, colorless liquid, Bp. 112-114 C. Yield: 127 grams (89%).1H-NMR (400 MHz, acetone-d6): delta4.30 (m); 19F-NMR (376.89 MHz, acetone-d6): -80.5 to -82.5 (m, 8F), -129.4 (m, 2F), -134.6 (dm, 1F).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Perfluoro(2-methyl-3-oxahexanoyl) fluoride, its application will become more common.
Reference:
Patent; DUPONT PERFORMANCE ELASTOMERS LLC; US2011/257423; (2011); A1;,
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