Related Products of 2062-98-8, A common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The methyl perfluoroalkyl ether carboxylate was prepared by esterfication of perfluorinated ether acid fluoride with methanol. A mixed solution of 41.11 g anhydrous triethylamine (0.40 mol) in 47.5 g anhydrous methanol (1.48 mol) was added dropwise into 185 g perfluoro-2,5-dimethyl-3,6-dioxa-nonanoic acid fluoride (0.37 mol) in a dry three-neck flask under agitation over a period of 2 h at 0 C. The mixture was agitated for another 4 h and the temperature of reaction mass was maintained at room temperature. Subsequently, the reaction mixture was poured into a separating funnel. The fluorocarbon layer was washed with sodium bicarbonate solution and dried over anhydrous sodium sulfate to obtain the crude product. The crude product was distilled to give 178.43 g methyl perfluoro-2,5-dimethyl-3,6-dioxa-nonanoate (yield 94%) boiling at 145 C at 760 mmHg. IR: 2969,1792, 1290, 1237, 1145, 1040, 994 cm-1. 1H-NMR (500 MHz, CDCl3): delta 3.99 (3H, s, CH3). 13C-NMR (125 MHz, CDCl3): delta 54.60 (-CH3-).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Shi, Xiang; Shi, Hongxin; Wu, Hongke; Shen, HaiMin; Research on Chemical Intermediates; vol. 44; 9; (2018); p. 5091 – 5105;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem