Category: 588-63-6

These common heterocyclic compound, 588-63-6, name is (3-Bromopropoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 588-63-6

Intermediate 110 1,1-Dimethylethyl (2/?,4S)-4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-({[3-(phenyloxy)propyl]oxy} methyl)- 1 -pyrrolidinecarboxylate1 ,1-Dimethylethyl (2R,4S)-4-{[(1 ,1-dimethylethyl)(dimethyl)silyl]oxy}-2-(hydroxymethyl)-1- pyrrolidinecarboxylate (0.6 g, 1.810 mmol) was diluted in THF (1 ml) to give a colorless solution. The resulting mixture was cooled down to 0 0C under argon. Then sodium hydride (0.217 g, 9.05 mmol) in THF (2ml_) was added to give a white suspension followed by [(3-bromopropyl)oxy]benzene 3-bromopropyl phenyl ether (0.779 g, 3.62 mmol) in THF (1 ml). The resulting mixture was stirred at rt over the week end (96 h).The reaction was then quenched by addition of water at 0 0C. The THF was removed in vacuo and the resulting crude was diluted in DCM and washed with 0.1 M HCI, sat NaHCOs using a hydrophobic frit. The organic layer was then concentrated in vacuo to yield a colorless oil. This resulting oil was loaded onto a 5 g silica SPE cartridge, then eluted sequentially with hexane DCM and EA. The corresponding fractions were combined and evaporated to afford the title compound (0.45 g, 53percent). LC-MS: m/z, 466 (M+H), rt 1.67 min.

The synthetic route of (3-Bromopropoxy)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/26197; (2009); A1;,
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Some common heterocyclic compound, 588-63-6, name is (3-Bromopropoxy)benzene, molecular formula is C9H11BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H11BrO

General procedure: 3,5-dimethyl-1-(3-phenoxypropyl)-1H-pyrazole (L1): A solution of 3,5-dimethyl-1H-pyrazole (0.30 g, 3.2 mmol) in DMF/THF (v/v = 1:1, 12 mL) was added to a suspension of NaH (0.15 g, 6.4 mmol) in DMF/THF (v/v = 2:1, 15 mL) and stirred at 60 ¡ãC for 2 h. Then, the resulting solution was added under stirring to a solution of 3-bromopropyl phenyl ether (0.70 g, 3.2 mmol) in DMF (7 mL). The mixture was allowed to stir for 24 h at 60 ¡ãC, cooled, and treated cautiously with H2O (5 mL) to decompose excess NaH. The solvents were then evaporated under reduced pressure. The residue was extracted with ethyl acetate (3 * 15 mL), washed with H2O (2 * 15 mL). The organic phase was dried over MgSO4 and filtered, before the solvent was evaporated under reduced pressure. After workup and purification by chromatographic column on silica gel (hexane/ethyl acetate, 90:10), L1 was obtained as a colorless oil (0.47 g, 64percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 588-63-6, its application will become more common.

Reference:
Article; Ulbrich, Ana H.D.P.S.; Campedelli, Roberta R.; Milani, Jorge L. Sonego; Santos, Joao H.Z. Dos; Casagrande, Osvaldo De L.; Applied Catalysis A: General; vol. 453; (2013); p. 280 – 286;,
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Related Products of 588-63-6,Some common heterocyclic compound, 588-63-6, name is (3-Bromopropoxy)benzene, molecular formula is C9H11BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 3,5-dimethyl-1-(3-phenoxypropyl)-1H-pyrazole (L1): A solution of 3,5-dimethyl-1H-pyrazole (0.30 g, 3.2 mmol) in DMF/THF (v/v = 1:1, 12 mL) was added to a suspension of NaH (0.15 g, 6.4 mmol) in DMF/THF (v/v = 2:1, 15 mL) and stirred at 60 ¡ãC for 2 h. Then, the resulting solution was added under stirring to a solution of 3-bromopropyl phenyl ether (0.70 g, 3.2 mmol) in DMF (7 mL). The mixture was allowed to stir for 24 h at 60 ¡ãC, cooled, and treated cautiously with H2O (5 mL) to decompose excess NaH. The solvents were then evaporated under reduced pressure. The residue was extracted with ethyl acetate (3 * 15 mL), washed with H2O (2 * 15 mL). The organic phase was dried over MgSO4 and filtered, before the solvent was evaporated under reduced pressure. After workup and purification by chromatographic column on silica gel (hexane/ethyl acetate, 90:10), L1 was obtained as a colorless oil (0.47 g, 64percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (3-Bromopropoxy)benzene, its application will become more common.

Reference:
Article; Ulbrich, Ana H.D.P.S.; Campedelli, Roberta R.; Milani, Jorge L. Sonego; Santos, Joao H.Z. Dos; Casagrande, Osvaldo De L.; Applied Catalysis A: General; vol. 453; (2013); p. 280 – 286;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 588-63-6, name is (3-Bromopropoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., name: (3-Bromopropoxy)benzene

Maslinic acid (MA) (150 mg, 0.3 mmol) was dissolved in dry DMF (5 mL), and finely grounded potassium carbonate (200 mg, 1.45 mmol) was added. After 60 min of stirring at 25 ¡ãC, (3-bromopropoxy)-benzene (150 mg, 0.7 mmol) was added, and stirring was continued for another 18 h. The mixture was poured into ice cold hydrochloride acid (5percent, 50 mL), and the white precipitate was filtered off. Chromatographic purification (silica gel, hexane/ethyl acetate, 7:3) followed by recrystallization (ethanol) gave the product; yield: 150 mg, 83percent; m.p. 166?170 ¡ãC; RF = 0.4 (n-hexane/ethyl acetate, 1:1); [alpha]D = +45.8¡ã (c 0.33, CHCl3); IR (KBr): nu = 3424vs, 2946vs, 2930vs, 2878m, 2864m, 1726vs, 1602m, 1498m, 1470s, 1458m, 1384s, 1364m, 1242s, 1202m, 1180m, 1172m, 1162s, 1124m, 1080m, 1052s, 1034m cm?1; 1H NMR (400 MHz, CDCl3): delta = 7.30?7.24 (m, 2H, CHaromat), 6.94 (dd, J = 7.3, 7.3 Hz, 1H, CHaromat), 6.88 (d, J = 8.0 Hz, 2H, CHaromat), 5.25 (dd, J = 3.4, 3.4 Hz, 1H, CH (12)), 4.27?4.14 (m, 2H, CH2 (31)), 4.03 (ddd, J = 6.1, 6.1, 1.5 Hz, 1H, CH2 (33)), 3.68 (ddd, J = 11.5, 9.7, 4.4 Hz, 1H, CH (2)), 2.99 (d, J = 9.5 Hz, 1H, CH (3)), 2.87 (dd, J = 13.8, 3.8 Hz, 1H, CH (18)), 2.18 (brs, 2H, OH), 2.15?2.06 (m, 2H, CH2 (32)), 2.00?1.86 (m, 2H, CHa (16) + CHa (1)), 1.83 (dd, J = 8.8, 3.4 Hz, 2H, CH2 (11)), 1.75?1.66 (ddd, J = 13.8, 13.8, 4.4 Hz, 1H, CHa (7)), 1.67?1.58 (m, 3H, CHa (19) + CHa (15) + CHb (16)), 1.57 (m, 1H, CH (9)), 1.54?1.45 (m, 2H, CHa (22) + CHa (6)), 1.43?1.35 (m, 1H, CHb (7)), 1.33?1.23 (m, 2H, CHa (21) + CHb (6)), 1.22?1.14 (m, 3H, CHb (19) + CHb (21) + CHb (22)), 1.11 (s, 3H, CH3 (27)), 1.02 (s, 3H, CH3 (23)), 1.05?0.95 (m, 1H, CHb (15)), 0.92 (s, 3H, CH3 (25)), 0.90 (s, 3H, CH3 (30)), 0.89 (s, 3H, CH3 (29)), 0.88?0.80 (m, 1H, CHb (1)), 0.81 (s, 3H, CH3 (24)), 0.80 (m, 1H, CH (5)), 0.66 (s, 3H, CH3 (26)) ppm; 13C NMR (100 Hz, CDCl3): delta = 177.8 (C=O, C28), 158.9 (Caromat, C34), 144.0 (C=CH, C13), 129.6 (CHaromat, C35), 122.4 (CH=C, C12), 120.9 (CHaromat, C36), 114.5 (CHaromat, C37), 84.1 (CHOH, C3), 69.1 (CHOH, C2), 64.3 (CH2, C31), 61.1 (CH2, C33), 55.4 (CH, C5), 47.7 (CH, C9), 46.9 (Cquart, C17), 46.5 (CH2, C1), 46.0 (CH2, C19), 41.9 (Cquart, C14), 41.4 (CH, C18), 39.5 (Cquart, C8), 39.3 (Cquart, C4), 38.4 (Cquart, C10), 34.0 (CH2, C21), 33.2 (CH3, C30), 32.7 (CH2, C7), 32.6 (CH2, C22), 30.9 (Cquart, C20), 28.8 (CH2, C32), 28.8 (CH3, C23), 27.7 (CH2, C15), 26.1 (CH3, C27), 23.8 (CH3, C29), 23.6 (CH2, C11), 23.1 (CH2, C16), 18.5 (CH2, C6), 17.1 (CH3, C26), 16.9 (CH3, C24), 16.7 (CH3, C25) ppm; MS (ESI, MeOH, source CID): m/z = 607.3 (20percent, [M + H]+), 629.3 (100percent, [M + Na]+), 929.3 (60percent, [3M + K + H]2+); analysis for C39H58O5 (606.87): C 77.18, H 9.63; found C 77.03, H 9.71.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 588-63-6.

Reference:
Article; Siewert, Bianka; Csuk, Rene; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 1 – 6;,
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Ether | (C2H5)2O – PubChem

Electric Literature of 588-63-6,Some common heterocyclic compound, 588-63-6, name is (3-Bromopropoxy)benzene, molecular formula is C9H11BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A suspension of the phenoxypropyl bromide (44) (0.3 mL, 1.90 mmol, d=1.365), piperidone hydrochloride hydrate (0.44 g, 2.86 mmol), K2CO3 (1.05 g, 7.62 mmol), anhydrous Na2SO4 (0.54 g, 3.81 mmol) and KI (47 mg, 0.286 mmol) in MeCN (20 mL) was stirred at reflux conditions for 2.5 hrs. The mixture was cooled to RT, diluted with water and extracted with EA. The extract was dried over Na2SO4, filtered, concentrated and the residue was purified by flash column chromatography, eluent 5percent MeOH in EA, to afford title compound 45 (0.45 g, quant. yield) as oil. (0383) 1H NMR: 500 MHz, CDCl3, delta (ppm): 7.30-7.26 (m, 2H), 6.96-6.90 (m 3H), 4.06 (t, J=6.3 Hz, 2H), 2.78 (t, J=6.1 Hz, 4H), 2.66 (t, J=7.1 Hz, 2H), 2.46 (t, J=6.8 Hz, 4H), 2.04-1.99 (m, 2H). MS: 233.3 (calcd.), 234.1 (M+H+, found).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (3-Bromopropoxy)benzene, its application will become more common.

Reference:
Patent; Mirati Therapeutics, Inc.; Marx, Matthew Arnold; Vaisburg, Arkadii; Christensen, James Gail; Galemmo, JR., Robert Anthony; (91 pag.)US2017/183308; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

588-63-6, name is (3-Bromopropoxy)benzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C9H11BrO

The 148mgNa dissolved in 20ml of absolute ethanol until complete dissolution, 6-(3,5-difluoro)benzyl-2-thiouracil 234mg (0.92mmol) and 1- (3-bromo-propoxy) benzene 297mg (1.38mmol) was added thereto, TLC the reaction was complete after stirring overnight at room temperature; column chromatography, P:E = 5:1,2:1,1:1, the final product was 222mg, as a white solid, a yield of 62.14percent

The synthetic route of 588-63-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Peking University; Zhang, Liang; FU, YUHONG; Qin, Hua; Wang, Xiao Wei; Liu, Jun Yi; (30 pag.)CN103864699; (2016); B;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 588-63-6, name is (3-Bromopropoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of (3-Bromopropoxy)benzene

tert-Butyl 4-(3-phenoxypropyl)piperazine-1-carboxylate (28). To a solution ofn-Boc-piperazine (1.08 g, 5.80 mmol) in dry DMF (10 ml) were added anhydrous potassiumcarbonate (4.01 g, 29.04 mmol) and compound 26 (1.5 g, 6.97 mmol). The reaction mixture was stirred at RT for 8 h. The potassium carbonate was removed by suction filtration and thesolvent was removed under reduced pressure. The residue was dissolved with water andextracted with ethyl acetate. The combined organic layers were dried over anhydrous sodiumsulfate and the solvent was removed by evaporation. The crude product was purified bycolumn chromatography using ethyl acetate:hexane (8:2) to give compound 28 (1.58 g, 85 percent).1H NMR (400 MHz, CDCI3) 8 1.39 (s, 9H), 1.92 (s, 2H), 2.36 (s, 4H), 2.48 (s, 2H), 3.39 (s, 4), 3.95(m, 2), 6.83 (m, 2H), 7.19 (m, 3H).

According to the analysis of related databases, 588-63-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; YOU, Youngjae; BIO, Moses; HOSSION, Abugafar; WO2013/163321; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem