Category: 588-63-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 588-63-6, name is (3-Bromopropoxy)benzene, A new synthetic method of this compound is introduced below., name: (3-Bromopropoxy)benzene

The 148mg Na dissolved in 20ml of absolute ethanol until complete dissolution, 6-benzyl-2-thiouracil200mg (0.92mmol) and 1-(3-bromopropoxy)benzene 297mg (1.38mmol) was added, at room temperature after stirring overnight the reaction was complete by TLC; column chromatography, P:E = 5:1,2:1,1:1, finally give 257 mg of the product, as a white solid, a yield of 79.17percent

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Peking University; Zhang, Liang; FU, YUHONG; Qin, Hua; Wang, Xiao Wei; Liu, Jun Yi; (30 pag.)CN103864699; (2016); B;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 588-63-6, name is (3-Bromopropoxy)benzene, A new synthetic method of this compound is introduced below., Computed Properties of C9H11BrO

2,4-diamino-5-hydroxy -1, 3, 5-tri-aza-9-oxa-spiro [5.5] undecane -1,3-diene-hydrochloride (0.47g, 0 . 002mol), sodium hydroxide (0.08g, 0 . 002mol), methanol 10 ml in mixed in the round-bottom flask, heating to reflux 30 minutes, the heat filters, concentrating the filtrate. By adding 1-bromo-3-phenoxy-propane (0.52g, 0 . 0024mol) and DMF2ml, stirring the mixture at room temperature. When consumes TLC monitoring raw materials, into a small amount of thick hydrogen PH value in order to adjust the bromate 2-3. Remove the solvent under reduced pressure, to obtain white solid, with ethanol: water = 10:1 ( volume ratio ) recrystallization, get white crystal 0.26g, yield 31.7percent, HPLC purity measured 99.6percent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shanghai Institute Of Pharmaceutical Industry(China State Institute of Pharmaceutical Industry); zhou, xiaotian; lin, kuaile; zhou, Weicheng; (41 pag.)CN103664972; (2016); B;,
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Related Products of 588-63-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 588-63-6, name is (3-Bromopropoxy)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

0.3 g (0.00089 mol) of N- [ (3R)-1-azabicyclo [2.2. 2] [OCT-3-YL]-9H-XANTHENE-9-CARBOXAMIDE] (Example 31) were dissolved in 6 [ML] of THF. To this solution 0.21 ml (0.287g, 0.001335 mol) of [(3-BROMOPROPOXY)] benzene were added. The mixture was refluxed during 4 hours and then stirred 17 h at room temperature. The reaction mixture was filtered and the solid obtained washed with ether several times and dried. 0.48 [G] (98percent) of the title product were obtained. m. p.: 278.5-279. [2C] [MS [M-BR] + :] 469 [APOS;H-NMR] (DMSO-d6) : [S] 1.80-2. 0 (m, 3H), 2.05-2. 30 (m, 4H), 3.15-3. 25 (m, [1H),] 3.30-3. 65 (m, 6H), 3.82 (m, [1H),] 4.05 (t, 2H), 4.10 (m, [1H),] 5.05 (s, [1H),] 6.90-7. 0 (m, 3H), 7.05-7. 20 (m, 4H), 7.25-7. 42 (m, 6H), 9.01 (d, [1H,] NH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Bromopropoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALMIRALL PRODESFARMA S.A.; WO2004/5285; (2004); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 588-63-6, name is (3-Bromopropoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C9H11BrO

To a flame-dried Schlenk tube containing CpFe(CO)2Cl (6) (10.3 mg, 0.05 mmol),3-bromopropyl phenyl ether (1j) (223 mg, 1.04 mmol), THF (0.25 mL), n-BuMgCl (2a)(2M in THF, 0.75 mL, 1.5 mmol), and 1,3-butadiene (90 mL as gas, 4.0 mmol) wereadded successively at ?78 C followed by stirring at 0 °C for 2 h and rt for 22 h. Thereaction was quenched by the addition of sat NH4Cl aq., extracted with Et2O (10 mL x3), concentrated, and purified by PTLC (eluent: hexane/Et2O = 99/1) to obtain heptylphenyl etherS2 (3ja) as yellow oil (79.5 mg, 40percent).

According to the analysis of related databases, 588-63-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Iwasaki, Takanori; Shimizu, Ryohei; Imanishi, Reiko; Kuniyasu, Hitoshi; Kambe, Nobuaki; Chemistry Letters; vol. 47; 6; (2018); p. 763 – 766;,
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Synthetic Route of 588-63-6,Some common heterocyclic compound, 588-63-6, name is (3-Bromopropoxy)benzene, molecular formula is C9H11BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 3,5-dimethyl-1-(3-phenoxypropyl)-1H-pyrazole (L1): A solution of 3,5-dimethyl-1H-pyrazole (0.30 g, 3.2 mmol) in DMF/THF (v/v = 1:1, 12 mL) was added to a suspension of NaH (0.15 g, 6.4 mmol) in DMF/THF (v/v = 2:1, 15 mL) and stirred at 60 °C for 2 h. Then, the resulting solution was added under stirring to a solution of 3-bromopropyl phenyl ether (0.70 g, 3.2 mmol) in DMF (7 mL). The mixture was allowed to stir for 24 h at 60 °C, cooled, and treated cautiously with H2O (5 mL) to decompose excess NaH. The solvents were then evaporated under reduced pressure. The residue was extracted with ethyl acetate (3 * 15 mL), washed with H2O (2 * 15 mL). The organic phase was dried over MgSO4 and filtered, before the solvent was evaporated under reduced pressure. After workup and purification by chromatographic column on silica gel (hexane/ethyl acetate, 90:10), L1 was obtained as a colorless oil (0.47 g, 64percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (3-Bromopropoxy)benzene, its application will become more common.

Reference:
Article; Ulbrich, Ana H.D.P.S.; Campedelli, Roberta R.; Milani, Jorge L. Sonego; Santos, Joao H.Z. Dos; Casagrande, Osvaldo De L.; Applied Catalysis A: General; vol. 453; (2013); p. 280 – 286;,
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Electric Literature of 588-63-6, A common heterocyclic compound, 588-63-6, name is (3-Bromopropoxy)benzene, molecular formula is C9H11BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

a) 6-Bromo-3-(3-phenoxy-propoxy)-pyridine-2-carboxylic acid methyl esterA mixture of -bromo-3-hydroxypicolinic acid methyl ester (lOOmg, 0.43 mmol), sodium hydride (60percent dispersion in mineral oil) (17.3mg, 0.43 mmol), 3-phenoxypropyl bromide(68 muL, 0.43 mmol), in dimethyl acetamide (1.5 mL) was heated at 9O0C for 3 hours. The reaction was allowed to cool, poured onto water and then extracted with ethyl acetate (2 x3mL). The organic layer was dried (MgSO4) and concentrated in vacuo. The resulting residue was purified by silica chromatography eluting with 100percent petroleum ether to 30percent ethyl acetate/petroleum ether to obtain a white solid (95mg, 60percent). 1H NMR (300 MHz,CDCl3) delta: 7.48 (IH, d), 7.24-7.21 (3H, m), 6.91-6.86 (3H, m), 4.19 (2H, t), 4.15 (2H, t),3.88 (3H, s), 2.30-2.22 (2H, m).

The synthetic route of 588-63-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH; WO2009/39553; (2009); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 588-63-6, These common heterocyclic compound, 588-63-6, name is (3-Bromopropoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of the appropriate aryloxyalkylbromides 9?16(5 mmol) commercially available or prepared as above-described,imidazole 7 or 1,2,4-triazole 8 (7.5 mmol), TEA (5 mmol) and catalyticamount of TBAB (0.1 g) in acetonitrile (3 mL) was heated undermicrowaves irradiation in a sealed vial at 100 C, 200 W, 150Psi, for 30?45 min. The solvent was removed in vacuo to give a residuewhich was suspended in water, alkalinized with NaOH 0.1 Nand extracted with dichloromethane (3 50 mL); the combinatedextracts were washed with water, dried, and evaporated to obtaina residue which was purified by flash column chromatography onsilica gel using ethyl acetate or ethyl acetate/methanol 9:1 as eluent.

The synthetic route of 588-63-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Salerno, Loredana; Pittala?, Valeria; Romeo, Giuseppe; Modica, Maria N.; Siracusa, Maria A.; Di Giacomo, Claudia; Acquaviva, Rosaria; Barbagallo, Ignazio; Tibullo, Daniele; Sorrenti, Valeria; Bioorganic and Medicinal Chemistry; vol. 21; 17; (2013); p. 5145 – 5153;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 588-63-6, These common heterocyclic compound, 588-63-6, name is (3-Bromopropoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of the appropriate aryloxyalkylbromides 9?16(5 mmol) commercially available or prepared as above-described,imidazole 7 or 1,2,4-triazole 8 (7.5 mmol), TEA (5 mmol) and catalyticamount of TBAB (0.1 g) in acetonitrile (3 mL) was heated undermicrowaves irradiation in a sealed vial at 100 C, 200 W, 150Psi, for 30?45 min. The solvent was removed in vacuo to give a residuewhich was suspended in water, alkalinized with NaOH 0.1 Nand extracted with dichloromethane (3 50 mL); the combinatedextracts were washed with water, dried, and evaporated to obtaina residue which was purified by flash column chromatography onsilica gel using ethyl acetate or ethyl acetate/methanol 9:1 as eluent.

The synthetic route of 588-63-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Salerno, Loredana; Pittala?, Valeria; Romeo, Giuseppe; Modica, Maria N.; Siracusa, Maria A.; Di Giacomo, Claudia; Acquaviva, Rosaria; Barbagallo, Ignazio; Tibullo, Daniele; Sorrenti, Valeria; Bioorganic and Medicinal Chemistry; vol. 21; 17; (2013); p. 5145 – 5153;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 588-63-6, name is (3-Bromopropoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 588-63-6

General procedure: To a solution of NaOH (32 mg, 0.8 mmol, 1.6 equiv), catalyst 1 (8.4mg, 0.025 mmol, 5 molpercent), NaI (37 mg, 0.25 mmol, 0.5 equiv), and OTMEDA (241 mg, 1.5 mmol, 3 equiv) in dry EtCMe2OH (4 mL),were added alkyl halide (0.5 mmol) and the phenylboronic acid (98mg, 0.8 mmol, 1.6 equiv) under a N2 atmosphere. The mixture was stirred at 80 ¡ãC for 24 h. The solution was diluted in Et2O (10 mL), filtered on a short pad of silica, washed with Et2O (3 ¡Á 10 mL), and concentrated to dryness under reduced pressure. The residue was purified with a flash purification system to give the coupling product( Tables 3 and 4).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 588-63-6.

Reference:
Article; Di Franco, Thomas; Boutin, Nicolas; Hu, Xile; Synthesis; vol. 45; 21; (2013); p. 2949 – 2958;,
Ether – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 588-63-6, name is (3-Bromopropoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 588-63-6, COA of Formula: C9H11BrO

EXAMPLE 15 3-(Octadecyloxy)-5-(3-phenoxypropoxy)benzoic acid phenylmethyl ester A mixture of 12 g (0.024 mol) of 3-hydroxy-5-(octadecyloxy)benzoic acid phenylmethyl ester, 6 ml (0.038 mol) of 3-phenoxypropyl bromide, 3.6 g (0.024 mol) of sodium iodide and 10 g (0.072 mol) of potassium carbonate in 400 ml of acetone and 80 ml of DMF was stirred at reflux for 46 hours. The reaction mixture was filtered and the filtrate was concentrated to dryness at reduced pressure. Water was added to the residue and the product was extracted with ethyl acetate. The dried extract was concentrated at reduced pressure to an oil which was purified by HPLC using 5percent ethyl acetate-hexane. The pure fractions were combined, triturated with hexane and filtered to give 14.6 g (96percent yield, mp 46¡ã-47¡ã) of 3-(octadecyloxy)-5-(3-phenoxypropoxy)benzoic acid phenylmethyl ester. The structure was confirmed by nmr and mass spectra. Anal. Calcd for C41 H58 O5: C, 78.05; H, 9.27. Found: C, 77.89; H, 9.03.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Hoffmann-La Roche Inc.; US5298652; (1994); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem