Adding a certain compound to certain chemical reactions, such as: 588-63-6, name is (3-Bromopropoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 588-63-6, COA of Formula: C9H11BrO
EXAMPLE 15 3-(Octadecyloxy)-5-(3-phenoxypropoxy)benzoic acid phenylmethyl ester A mixture of 12 g (0.024 mol) of 3-hydroxy-5-(octadecyloxy)benzoic acid phenylmethyl ester, 6 ml (0.038 mol) of 3-phenoxypropyl bromide, 3.6 g (0.024 mol) of sodium iodide and 10 g (0.072 mol) of potassium carbonate in 400 ml of acetone and 80 ml of DMF was stirred at reflux for 46 hours. The reaction mixture was filtered and the filtrate was concentrated to dryness at reduced pressure. Water was added to the residue and the product was extracted with ethyl acetate. The dried extract was concentrated at reduced pressure to an oil which was purified by HPLC using 5percent ethyl acetate-hexane. The pure fractions were combined, triturated with hexane and filtered to give 14.6 g (96percent yield, mp 46¡ã-47¡ã) of 3-(octadecyloxy)-5-(3-phenoxypropoxy)benzoic acid phenylmethyl ester. The structure was confirmed by nmr and mass spectra. Anal. Calcd for C41 H58 O5: C, 78.05; H, 9.27. Found: C, 77.89; H, 9.03.
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Reference:
Patent; Hoffmann-La Roche Inc.; US5298652; (1994); A;,
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