Application of 588-63-6, These common heterocyclic compound, 588-63-6, name is (3-Bromopropoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of the appropriate aryloxyalkylbromides 9?16(5 mmol) commercially available or prepared as above-described,imidazole 7 or 1,2,4-triazole 8 (7.5 mmol), TEA (5 mmol) and catalyticamount of TBAB (0.1 g) in acetonitrile (3 mL) was heated undermicrowaves irradiation in a sealed vial at 100 C, 200 W, 150Psi, for 30?45 min. The solvent was removed in vacuo to give a residuewhich was suspended in water, alkalinized with NaOH 0.1 Nand extracted with dichloromethane (3 50 mL); the combinatedextracts were washed with water, dried, and evaporated to obtaina residue which was purified by flash column chromatography onsilica gel using ethyl acetate or ethyl acetate/methanol 9:1 as eluent.
The synthetic route of 588-63-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Salerno, Loredana; Pittala?, Valeria; Romeo, Giuseppe; Modica, Maria N.; Siracusa, Maria A.; Di Giacomo, Claudia; Acquaviva, Rosaria; Barbagallo, Ignazio; Tibullo, Daniele; Sorrenti, Valeria; Bioorganic and Medicinal Chemistry; vol. 21; 17; (2013); p. 5145 – 5153;,
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