Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 588-63-6, name is (3-Bromopropoxy)benzene, A new synthetic method of this compound is introduced below., Computed Properties of C9H11BrO
2,4-diamino-5-hydroxy -1, 3, 5-tri-aza-9-oxa-spiro [5.5] undecane -1,3-diene-hydrochloride (0.47g, 0 . 002mol), sodium hydroxide (0.08g, 0 . 002mol), methanol 10 ml in mixed in the round-bottom flask, heating to reflux 30 minutes, the heat filters, concentrating the filtrate. By adding 1-bromo-3-phenoxy-propane (0.52g, 0 . 0024mol) and DMF2ml, stirring the mixture at room temperature. When consumes TLC monitoring raw materials, into a small amount of thick hydrogen PH value in order to adjust the bromate 2-3. Remove the solvent under reduced pressure, to obtain white solid, with ethanol: water = 10:1 ( volume ratio ) recrystallization, get white crystal 0.26g, yield 31.7percent, HPLC purity measured 99.6percent.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shanghai Institute Of Pharmaceutical Industry(China State Institute of Pharmaceutical Industry); zhou, xiaotian; lin, kuaile; zhou, Weicheng; (41 pag.)CN103664972; (2016); B;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem