Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 588-63-6, name is (3-Bromopropoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of (3-Bromopropoxy)benzene
tert-Butyl 4-(3-phenoxypropyl)piperazine-1-carboxylate (28). To a solution ofn-Boc-piperazine (1.08 g, 5.80 mmol) in dry DMF (10 ml) were added anhydrous potassiumcarbonate (4.01 g, 29.04 mmol) and compound 26 (1.5 g, 6.97 mmol). The reaction mixture was stirred at RT for 8 h. The potassium carbonate was removed by suction filtration and thesolvent was removed under reduced pressure. The residue was dissolved with water andextracted with ethyl acetate. The combined organic layers were dried over anhydrous sodiumsulfate and the solvent was removed by evaporation. The crude product was purified bycolumn chromatography using ethyl acetate:hexane (8:2) to give compound 28 (1.58 g, 85 percent).1H NMR (400 MHz, CDCI3) 8 1.39 (s, 9H), 1.92 (s, 2H), 2.36 (s, 4H), 2.48 (s, 2H), 3.39 (s, 4), 3.95(m, 2), 6.83 (m, 2H), 7.19 (m, 3H).
According to the analysis of related databases, 588-63-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; YOU, Youngjae; BIO, Moses; HOSSION, Abugafar; WO2013/163321; (2013); A1;,
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