Category: ethers-buliding-blocks

Solubility Measurement and Thermodynamic Properties Calculation for Several CO₂ + Ether Absorbent Systems was written by Li, Yun;You, Yanhong;Huang, Weijia;Yang, Jie. And the article was included in Journal of Chemical & Engineering Data in 2019.Quality Control of 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

Six phys. absorbents with the ether groups were selected for CO₂ absorption: tetraethylene glycol di-Me ether (TEGDME), diethylene glycol monohexyl ether, 2-butoxyethyl ether, triethylene glycol monobutyl ether, ethylene glycol di-Bu ether, and dipropylene glycol di-Me ether (DPGDME). CO₂ solubilities in these absorbents were measured at 273.15 and 283.15 K and 0-1.2 MPa. Henry’s constants of these CO₂ + ether absorbent systems were calculated and analyzed at 273.15 K. The ether group is found more powerful than the methylene group, and the Et group is more effective than the hydroxyl group to improve the absorption ability of the absorbents. A lower temperature tends to facilitate the absorption process by increasing the absorption ability. Henry’s constants and mass solubilities of the ether absorbents were compared with those of the ionic liquids, common solvents, and other absorbents. TEGDME and DPGDME are potential absorbents according to the evaluation in both mole and mass fraction. The thermodn. properties, such as entropy, enthalpy, and Gibbs free energy of solution, for CO₂ + the ether absorbent systems were calculated and discussed for potential development of corresponding CO₂ capture processes. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Quality Control of 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 2-(2-(Hexyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish was written by Du, Zheng-Cai;Xia, Zhong-Shang;Huang, Yan-Feng;Peng, Yi;Cao, Bing-Bing;Li, Chun-Qi;Liang, Yun-Fei;Zhao, Fang-Hui;Zhang, Ming-Zhe;Chen, Zhang-Mei;Hou, Xiao-Tao;Hao, Er-Wei;Deng, Jia-Gang. And the article was included in Journal of Applied Toxicology in 2021.SDS of cas: 33171-05-0 The following contents are mentioned in the article:

Momordica cochinchinensis (Lour.) Spreng is an indigenous South Asian edible fruit, and seeds of Momordica cochinchinensis have been used therapeutically in traditional Chinese medicine. Previous studies have shown that M. cochinchinensis seed (Momordicae Semen) has various pharmaceutical properties such as antioxidant and anti-ulcer effects as well as contains secondary metabolites with potential anticancer activities such as triterpenoids and saponins. Recent studies reported that water extract and ethanol extract of M. cochinchinensi seed were tested on mammals using an acute toxic classic method as OECD guidelines 420. No matter injected i.v. or i.m., animals died within several days. In this study, zebrafish embryos were exposed to various doses of Cochinchina momordica seed extract (CMSE) from 2 dpf (days post fertilization, dpf) to 3 dpf. CMSE-induced cardiotoxicity such as pericardial edema, cardiac apoptosis, increased ROS production, cardiac neutrophil infiltration, decreased blood flow velocity, and reduced expression of three marker genes of cardiac functions were found in zebrafish roughly in a dose-dependent manner. These results suggest that CMSE may induce cardiotoxicity through pathways involved in inflammation, oxidative stress, and apoptosis. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0SDS of cas: 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Alkali-catalyzed liquefaction of pinewood sawdust in ethanol/water co-solvents was written by Hu, Yulin;Gu, Zicheng;Li, Wenbin;Xu, Chunbao. And the article was included in Biomass and Bioenergy in 2020.Name: 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

In this study, pinewood sawdust was liquefied in either ethanol/water co-solvents (50/50, weight/weight) or pure water at 300°C for 30 min and 10 wt% of feedstock loading, with or without the use of Na₂CO₃ or NaOH as a catalyst. The phys. and chem. properties of liquefaction products (bio-crude oil and solid residue) were comprehensively characterized by FT-IR, GC-MS, elemental, GPC and TGA analyses. The results showed that the highest biomass conversion of approx. 98% was obtained in ethanol/water mixed solvents and without catalyst, along with a maximum yield of bio-crude oil (∼48 wt%). The HHV of crude oil was within the range of 26-30 MJ/kg. The results indicated that the beneficial effect of ethanol on the bio-crude oil yield might be compromised by adding Na₂CO₃ or NaOH into the liquefaction system under investigated reaction conditions. As suggested by GPC anal., the bio-crude oil obtained in ethanol/water co-solvents from both non-catalytic and catalytic liquefaction contained a slightly higher mol. weight than that obtained in pure water. Addnl., TGA results indicated that the b.p. distribution of bio-crude oil was only affected by ethanol addition, whereas, the effect of the catalyst was found to be minor. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Name: 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Anti-enteroviral activity of new MDL-860 analogues: synthesis, in vitro/in vivo studies and QSAR analysis was written by Nikolova, Ivanka;Slavchev, Ivaylo;Ravutsov, Martin;Dangalov, Miroslav;Nikolova, Yana;Zagranyarska, Irena;Stoyanova, Adelina;Nikolova, Nadya;Mukova, Lucia;Grozdanov, Petar;Nikolova, Rosica;Shivachev, Boris;Kuz’min, Victor E.;Ognichenko, Liudmila N.;Galabov, Angel S.;Dobrikov, Georgi M.. And the article was included in Bioorganic Chemistry in 2019.HPLC of Formula: 103-16-2 The following contents are mentioned in the article:

A series of 60 nitrobenzonitrile analogs of the anti-viral agent MDL-860 were synthesized (50 of which are new) and evaluated for their activity against three types of enteroviruses (coxsackievirus B1, coxsackievirus B3 and poliovirus 1). Among them, six diaryl ethers (20e, 27e, 28e, 29e, 33e and 35e) demonstrated high in vitro activity (SI > 50) towards at least one of the tested viruses and very low cytotoxicity against human cells. Compound 27e, 2-(2,5-difluorophenoxy)-5-nitrobenzonitrile(I), possesses the broadest spectrum of activity towards all tested viruses in the same way as MDL-860 does. The most active derivatives (I), 29e 2-(2-chloro-5-fluorophenoxy)-5-nitrobenzonitrile (II) and 35e 2-(3,4-Dibromophenoxy)-5-nitrobenzonitrile(III) against coxsackievirus B1 were tested in vivo in newborn mice exptl. infected with 20 MLD₅₀ of coxsackievirus B1. II showed promising in vivo activity (protection index 26% and 4 days lengthening of mean survival time). QSAR anal. of the substituent effects on the in vitro cytotoxicity (CC₅₀) and anti-viral activity of the nitrobenzonitrile derivatives was carried out and adequate QSAR models for the anti-viral activity of the compounds against poliovirus 1 and coxsackievirus B1 were constructed. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2HPLC of Formula: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A small-angle neutron scattering study of nonionic surfactant molecules at the water-oil interface: area per molecule, microemulsion domain size, and rigidity was written by Sottmann, T.;Strey, R.;Chen, S.-H.. And the article was included in Journal of Chemical Physics in 1997.Application of 112-59-4 The following contents are mentioned in the article:

The small-angle neutron scattering (SANS) of bicontinuous microemulsions of 19 different water-n-alkane-C_iE_j (n-alkylpolyglycol ether) systems was measured. All scattering curves exhibit a broad scattering peak which permits determining the characteristic length scale ξ for bicontinuous structures at sym. water and oil volume fractions, i.e., φ=0.5. Various random models predict ξ = aδφ(1 – φ)/φ_c. ξ Is indeed determined to be inversely proportional to the surfactant volume fraction φ_c. Approximating the effective surfactant chain length δ by δ = v_c/a_c, where a_c and v_c are the area and the volume of the surfactant mol., the numerical value for a is determined to be a = 7.16, which is close to, but significantly different from those used in theor. models. The head group area a_c at the water-oil interface is obtained from the large q part of the scattering curves. It is found to be independent of i and k, the carbon numbers of the alkyl chain of the surfactant and of the alkane, resp. However, it depends strongly, and nearly linearly, on the head group size j of the surfactant. Within exptl. error it is described by a_c = 29.3 + 6.20j (Ų). This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Application of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Subcritical water extraction of antioxidants from Curculigo latifolia root was written by Zabidi, Nur Athirah;Ishak, Nur Akmal;Hamid, Muhajir;Ashari, Siti Efliza. And the article was included in Journal of Chemistry in 2019.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

This study aims to extract antioxidant compounds from Curculigo latifolia root by subcritical water extraction (SWE). +e influence of extraction temperature and time on the antioxidant activity of C. latifolia root extract was investigated in terms of extraction yield, total phenolic content (TPC), total flavonoid content (TFC), 2, 2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. +e highest extraction yield (36.5%), TPC (92.55 mg GAE/g), TFC (13.26 mg RE/g), and antioxidant activities by ABTS (66.8 mg trolox equivalent/g sample) and DPPH (128.7 mg trolox equivalent/g sample) were detected at 180°C and 30 min extraction time. Based on the results, the optimum condition was selected at 180°C and 30 min of extraction +e sample was screened by using liquid chromatog.-mass spectrometry (LC-MS) anal. where the phenolic compounds detected were structured based on their [M-H]-peak. +e detected phenolic compounds were monobenzone, hydroquinone, phloridzin, pomiferin, mundulone, scandenin, and di-Me caffeic acid. According to these findings, SWE is a promising, environmentally friendly, and efficient technol. in the exploitation of natural products for the development of food and nutraceutical commodities. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Evolution of sulfur during fast pyrolysis of sulfonated Kraft lignin was written by Han, Tong;Sophonrat, Nanta;Evangelopoulos, Panagiotis;Persson, Henry;Yang, Weihong;Joensson, Paer. And the article was included in Journal of Analytical and Applied Pyrolysis in 2018.Safety of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Sulfonated Kraft lignin, the most available com. lignin of today, has high sulfur content due to the extraction and the subsequent sulfonation processes. In this work, the evolution of sulfur during fast pyrolysis of sulfonated Kraft lignin has been studied. Fast Pyrolysis experiments have been done using Py-GC/MS. It is found that main sulfur-containing products in the pyrolytic vapors are present as the following small mol. compounds: H₂S, SO₂, CH₃SH, CH₃SCH₃, and CH₃SSCH₃. This indicates that sulfur-containing radicals preferentially combine with the other small radicals such as ·H and ·CH₃ during fast pyrolysis process. Sulfur is suggested to be mainly present as sulfite (-SO^–₃) and sulfide (-S-) in the sulfonated Kraft lignin. Sulfite that is incorporated into lignin during the sulfonation process mainly result in the formation of SO₂. The nature of the sulfur links created during the Kraft pulping process is difficult to determine, but they are supposed to mainly exist in form of sulfide (-S-) bonds, which lead to the formation of H₂S, CH₃SH, CH₃SCH₃ and CH₃SSCH₃. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Safety of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lignin-to-Liquid-Solvolysis (LtL) of Organosolv Extracted Lignin was written by Loehre, Camilla;Laugerud, Gro-Anita Aakre;Huijgen, Wouter J. J.;Barth, Tanja. And the article was included in ACS Sustainable Chemistry & Engineering in 2018.Safety of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Utilization of lignocellulosic biomass as a future energy source is a research field of widespread growth. The lignin fraction has potential as a renewable resource to provide building blocks for the chem. industry and is the most prominent source of bio-based aromatics Lignin, combined with formic acid and water under high temperature and pressure, is converted to a bio-oil rich in alkylated phenols and aliphatic hydrocarbons in a unique conversion process termed the LtL-process (lignin-to-liquid). In this work, this conversion technique has shown to be applicable to a variety of lignins, with organosolv extracted lignin as the main focus because of its high purity. The organosolv lignins appeared to be well suited for LtL-conversion generating higher yields of bio-oil than a lignin-rich residue from enzymic hydrolysis. 31P-NMR and GC-MS showed that the O/C ratios of the bio-oils decreases with increasing reaction temperature during LtL-solvolysis due to a decrease in methoxylated phenols and an increase in phenols with no methoxy substituent. This was verified by partial least squares (PLS) regression anal. and elemental anal. of the feedstocks and resulting bio-oils, from which an effective hydrodeoxygenation during LtL-conversion was evident too. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Safety of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quantifying polypeptoid conformational landscapes through integrated experiment and simulation was written by Jiao, Sally;DeStefano, Audra;Monroe, Jacob I.;Barry, Mikayla;Sherck, Nicholas;Casey, Thomas;Segalman, Rachel A.;Han, Songi;Shell, M. Scott. And the article was included in Macromolecules (Washington, DC, United States) in 2021.Computed Properties of C3H9NO The following contents are mentioned in the article:

We combine experiment and simulation to develop a powerful, validated approach for characterizing the conformational landscapes of disordered polypeptoids. Polypeptoids have become an important class of polymers, capable of precisely defined sequences while remaining gram-synthesizable-properties that have driven a rapidly expanding set of applications, including antifoulants, therapeutics, sensing, and directed self-assembly. The characterization of polypeptoid structure provides critical mol. insight into sequence-structure-function relationships. Structurally disordered polypeptoids require new approaches to interrogate their wide range of conformations in solution Here, we measure full end-to-end distance distributions, instead of configurational averages, using double electron-electron resonance (DEER) spectroscopy and enhanced sampling mol. modeling. We demonstrate excellent agreement between the experiments and simulations for a set of model hydrophilic polypeptoids. Moreover, we illustrate the utility of this combined experiment-simulation approach in probing structure-function relationships by characterizing the basic polymer physics of this polypeptoid series, demonstrating that the polypeptoids probed here exhibit excluded volume behavior. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Virtual screening and drug repurposing experiments to identify potential novel selective MAO-B inhibitors for Parkinson’s disease treatment was written by Crisan, Luminita;Istrate, Daniela;Bora, Alina;Pacureanu, Liliana. And the article was included in Molecular Diversity in 2021.Related Products of 103-16-2 The following contents are mentioned in the article:

The main study’s purpose is to detect novel natural products (NPs) that are potentially selective MAO-B inhibitors and, addnl., to computationally reposition the marketed drugs with a new therapeutic role for Parkinson’s disease. To reach the goals, 3D similarity search, docking, ADMETox, and drug repurposing approaches were employed. Thus, an unbiased benchmarking dataset was built including selective and nonselective inhibitors for MAO-B compliant with both ligand- and structure-based virtual screening approaches. A retrospective and prospective mining scenario was applied to SPECS NP and DrugBank databases to detect novel scaffolds with potential benefits for Parkinson’s disease patients. Out of the three best selected natural products, cardamomin showed excellently predicted drug-like properties, superior pharmacol. profile, and specific interactions with MAO-B active site, indicating a potential selectivity over MAO-B. Two marketed drugs, fenamisal and monobenzone, were proposed as promising candidates repurposed for Parkinson’s disease. The application of shape, physicochem., and electrostatic similarity searches protocol emerged as a plausible solution to explore MAO-B inhibitors selectivity. This protocol might serve as a rewarding tool in early drug discovery and can be extended to other protein targets. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem