Category: ethers-buliding-blocks

A new synthetic biology approach for the production of curcumin and its glucoside in Atropa belladonna hairy roots was written by Singh, Sailendra;Pandey, Pallavi;Akhtar, Qussen Md.;Negi, Arvind Singh;Banerjee, Suchitra. And the article was included in Journal of Biotechnology in 2021.Application In Synthesis of Bisdemethoxycurcumin The following contents are mentioned in the article:

Curcumin has ignited global interest as an elite drugable mol., owing to its time-honoured pharmacol. activities against diverse human ailments. Limited natural accessibility and poor oral bioavailability caused major hurdles in the curcumin-based drug development process. We report the first successful testimony of curcumin and its glucoside synthesis in Atropa belladonna hairy roots (HR) through metabolic engineering. Re-routing the inherent biosynthetic precursors of the phenylpropanoid pathway of A. belladonna by heterologous expression of key curcumin biosynthetic pathway genes (i.e., Diketide-CoA synthase-DCS and Curcumin synthase-CURS3) and glucosyltransferase gene (CaUGT2) resulted in the production of curcumin and its glucoside in HR clones. Under shake-flask cultivation, the PGD2-HR1clone bearing DCS/ CURS3 genes showed the maximum curcumin yield (180.62 ± 4.7 μg/g DW), while the highest content of curcumin monoglucoside (32.63 ± 2.27 μg/g DW) along with curcumin (67.89 ± 2.56 μg/g DW) were noted in the PGD3-HR3 clone co-expressing DCS/CURS3 and CaUGT2 genes. Bioreactor up-scaling showed yield improvements in the PGD2-HR1 (2.3 fold curcumin) and the PGD3-HR3 clone (0.9 and 1.65 folds of curcumin-monoglucoside and curcumin resp.). These findings proved the advantageous use of HR cultures as the production source for curcumin and its glucoside, which remained unexplored so far. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Application In Synthesis of Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of Bisdemethoxycurcumin

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Selective cleavage of C-O bond in lignin and lignin model compounds over iron/nitrogen co-doped carbon supported nickel catalyst was written by Guo, Jia-Pei;Liu, Fang-Jing;Bie, Lei-Lei;Si, Xing-Gang;Li, Yan-Hong;Song, Ping;Liu, Nian;Zhao, Yun-Peng;Huang, Zai-Xing;Cao, Jing-Pei;Wei, Xian-Yong. And the article was included in Fuel in 2022.SDS of cas: 103-16-2 The following contents are mentioned in the article:

The utilization of lignin to produce high value-added chems. is conducive to alleviating the fossil energy crisis. Herein, Ni nanoparticles supported on iron/nitrogen co-doped carbon was prepared by co-pyrolysis and solvothermal reduction method for catalytic hydrogenolysis (CH) of dealkaline lignin and its model compounds The catalysts were prepared under different calcination temperature, N/C ratio and Ni loading, and the optimal catalyst was Ni_10%@Fe/NC_0.33-800 (calcination temperature: 800°C, N/C ratio: 0.33, Ni loading: 10%) based the on the CH of benzyl Ph ether (BPE). Ni_10%@Fe/NC_0.33-800 showed good catalytic performance on the selective cleavage of C-O bond of lignin and its model compounds The BPE conversion reached up to 97.7% over Ni_10%@Fe/NC_0.33-800 under mild conditions (230°C, 1 MPa H₂, and 0.5 h) with toluene and cyclohexanol as major products. Catalyst characterizations suggest that N content affects the formation of NiFe alloy and the synergistic effect between Ni and Fe plays an important role in CH of BPE. Moreover, Ni_10%@Fe/NC_0.33-800 could promote the cleavage of C-O bonds in dealkaline lignin through CH and hence enhance producing aromatics such as phenols, aromatic ethers, and aromatic esters, among which phenols are the main aromatics with guaiacols predominant. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2SDS of cas: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.SDS of cas: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Selective cleavage of C-O bond in lignin and lignin model compounds over iron/nitrogen co-doped carbon supported nickel catalyst was written by Guo, Jia-Pei;Liu, Fang-Jing;Bie, Lei-Lei;Si, Xing-Gang;Li, Yan-Hong;Song, Ping;Liu, Nian;Zhao, Yun-Peng;Huang, Zai-Xing;Cao, Jing-Pei;Wei, Xian-Yong. And the article was included in Fuel in 2022.Formula: C13H12O2 The following contents are mentioned in the article:

The utilization of lignin to produce high value-added chems. is conducive to alleviating the fossil energy crisis. Herein, Ni nanoparticles supported on iron/nitrogen co-doped carbon was prepared by co-pyrolysis and solvothermal reduction method for catalytic hydrogenolysis (CH) of dealkaline lignin and its model compounds The catalysts were prepared under different calcination temperature, N/C ratio and Ni loading, and the optimal catalyst was Ni_10%@Fe/NC_0.33-800 (calcination temperature: 800°C, N/C ratio: 0.33, Ni loading: 10%) based the on the CH of benzyl Ph ether (BPE). Ni_10%@Fe/NC_0.33-800 showed good catalytic performance on the selective cleavage of C-O bond of lignin and its model compounds The BPE conversion reached up to 97.7% over Ni_10%@Fe/NC_0.33-800 under mild conditions (230°C, 1 MPa H₂, and 0.5 h) with toluene and cyclohexanol as major products. Catalyst characterizations suggest that N content affects the formation of NiFe alloy and the synergistic effect between Ni and Fe plays an important role in CH of BPE. Moreover, Ni_10%@Fe/NC_0.33-800 could promote the cleavage of C-O bonds in dealkaline lignin through CH and hence enhance producing aromatics such as phenols, aromatic ethers, and aromatic esters, among which phenols are the main aromatics with guaiacols predominant. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Resveratrol and Curcumin for Chagas Disease Treatment-A Systematic Review was written by Imperador, Carlos Henrique Lima;Scarim, Caue Benito;Bosquesi, Priscila Longhin;Lopes, Juliana Romano;Cardinalli Neto, Augusto;Giarolla, Jeanine;Ferreira, Elizabeth Igne;dos Santos, Jean Leandro;Chin, Chung Man. And the article was included in Pharmaceuticals in 2022.Related Products of 33171-05-0 The following contents are mentioned in the article:

Chagas disease (CD) is a neglected protozoan infection caused by Trypanosoma cruzi, which affects about 7 million people worldwide. There are two available drugs in therapeutics, however, they lack effectiveness for the chronic stage-characterized mainly by cardiac (i.e., cardiomyopathy) and digestive manifestations (i.e., megaesophagus, megacolon). Due to the involvement of the immuno-inflammatory pathways in the disease′s progress, compounds exhibiting antioxidant and anti-inflammatory activity seem to be effective for controlling some clin. manifestations, mainly in the chronic phase. Resveratrol (RVT) and curcumin (CUR) are natural compounds with potent antioxidant and anti-inflammatory properties and their cardioprotective effect have been proposed to have benefits to treat CD. Such effects could decrease or block the progression of the disease′s severity. The purpose of this systematic review is to analyze the effectiveness of RVT and CUR in animal and clin. research for the treatment of CD. The study was performed according to PRISMA guidelines and it was registered on PROSPERO (CDR42021293495). The results did not find any clin. study, and the animal research was analyzed according to the SYRCLES risk of bias tools and ARRIVE 2.0 guidelines. We found 9 eligible reports in this study. We also discuss the potential RVT and CUR derivatives for the treatment of CD as well. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Related Products of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cleaning properties of single-phase hydrocarbon-based microemulsion systems was written by Klier, J.;Suarez, R. S.;Green, D. P.;Kumar, A. M.;Hoffman, M.;Tucker, C. J.;Landes, B.;Redwine, D.. And the article was included in Journal of the American Oil Chemists’ Society in 1997.Computed Properties of C10H22O3 The following contents are mentioned in the article:

Single-phase hydrocarbon-based microemulsions with low volatile organic carbon levels were evaluated in terms of solvent-like cleaning properties, and can help meet regulatory requirements. The rheol. and petroleum jelly solubilization properties of model microemulsion systems that contained linear alkylbenzenesulfonate surfactant, diethylene glycol monohexyl ether co-surfactant, and equal volumes of hydrocarbon solvent and water were evaluated as a function of microemulsion structure and composition The hydrocarbons were linear alkanes C₅ to ₁₂. Single-phase microemulsions with low surfactant contents and broad formulation flexibility were obtained through the use of efficient anionic surfactants and low NaCl electrolyte levels. The microemulsion structure was advanced from solvent-continuous to water-continuous by varying the solvent alkane carbon number or the electrolyte content, whereas the liquid crystal content was controlled via cosurfactant concentration Both microemulsion structure and viscosity influenced solubilization rates. Low-viscosity, solvent-continuous microemulsions showed solubilization rates comparable to those found with solvent-based systems, while water-continuous microemulsions showed relatively poor solubilization rates. Microemulsions containing dispersed liquid crystals exhibited high viscosity and low solubilization rates. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Computed Properties of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Water Solubility and Surface Property of Alkyl Di-/Tri-/Tetraoxyethyl β-D-Xylopyranosides was written by Wu, Xiubing;Chen, Langqiu;Fan, Yulin;Fu, Fang;Li, Jiping;Zhang, Jing. And the article was included in Journal of Agricultural and Food Chemistry in 2019.Computed Properties of C10H22O3 The following contents are mentioned in the article:

Alkyl di-/tri-/tetraoxyethyl β-D-xylopyranosides as derivatives of alkyl xylosides are a class of non-ionic sugar-based surfactants. They were stereoselectively synthesized by the Helferich method. Their properties including hydrophilic-lipophilic balance number, water solubility, surface property, foam property, emulsifying property, and thermotropic liquid crystal property were mainly investigated. The results showed that their water solubility decreased with increasing the alkyl chain length and increasing the number of the oligooxyethyl fragment. The critical micelle concentration had a monotonous decreasing trend with increasing the alkyl chain length. Nonyl di-/tri-/tetraoxyethyl β-D-xylopyranosides [-(OCH₂CH₂)_m-, where m = 2, 3, and 4] exhibited the most excellent foaming ability and foam stability. In the n-octane/water system, dodecyl tetraoxyethyl β-D-xylopyranosides and tetradecyl tetraoxyethyl β-D-xylopyranosides had the strongest emulsion ability. In addition, some alkyl di-/tri-/tetraoxyethyl β-D-xylopyranosides had thermotropic liquid crystal properties. Such sugar-based surfactants, alkyl di-/tri-/tetraoxyethyl β-D-xylopyranosides, will be expected to develop for a variety of practical application. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Computed Properties of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A novel peptidomimetic therapeutic for selective suppression of lung cancer stem cells over non-stem cancer cells was written by Shukla, Satya Prakash;Raymond, Aaron;Rustagi, Vineeta;Kedika, Samanth R.;Tran, Olivia;Wang, Liye;Guo, Bin;Udugamasooriya, D. Gomika. And the article was included in Bioorganic Chemistry in 2021.Recommanded Product: 2-Methoxyethylamine The following contents are mentioned in the article:

Cancers are highly heterogeneous and typically contain a small subset of drug-resisting cells called tumor initiating cells or cancer stem cells (CSCs). CSCs can self-renew, divide asym., and often cause tumor invasion and metastasis. Therefore, treatments specifically targeting CSCs are critical to improve patient survival. Recently, we identified a highly specific peptidomimetic (peptoid – PCS2) that selectively binds to the CSC subpopulation of lung cancer over the remaining cancer cells (non-CSCs). Subsequently, we identified plectin as the target of PCS2. Plectin is an intracellular structural protein, which is involved in tumor invasion and metastasis when it appears on cell surface. While PCS2 monomer did not display any anti-cancer activity, we designed a series of homo-dimeric versions of PCS2, and identified PCS2D1.2 optimized homo-dimer that displayed highly specific cytotoxicity towards CSCs over non-CSCs. PCS2D1.2 effectively blocked the in vitro colony formation and cell migration, hallmarks of CSCs. Furthermore, PCS2D1.2 reduced the in vivo tumor formation. In both in vitro and in vivo studies, PCS2D1.2 effectively reduced plectin expression and/or plectin-rich CSCs, but had no effect on non-CSCs. Therefore, PCS2D1.2 has the potential to be developed as a highly CSC specific drug candidate, which can be used in combination with current anti-cancer drugs. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient Ni-based catalysts for the hydrotreatment of lignin dimer model compounds to cycloalkanes/cycloalkanols was written by Chen, Changzhou;Wu, Dichao;Liu, Peng;Xia, Haihong;Zhou, Minghao;Hou, Xinglong;Jiang, Jianchun. And the article was included in Reaction Chemistry & Engineering in 2021.Name: 4-Benzyloxyphenol The following contents are mentioned in the article:

The noble-metal catalytic cleavage of ether bonds in lignin to obtain aromatic chems. has achieved great success, and the development of a low-cost efficient catalyst is crucial. Herein, Ni_xLa_y/CNT was designed for the hydrogenolysis of benzyl Ph ether (BPE), di-Ph ether (DPE) and 2-phenethyl Ph ether (PPE) under a relatively mild condition. Owing to the synergistic effect of Ni with La, the Ni-La catalyst was especially active. Moreover, not only could the Ni-La catalyst fracture the C-O bond, but it could also transform aromatic rings to produce cycloalkanes. Physicochem. characterizations were carried out by means of XRD, TEM, H₂-TPR, NH₃-TPD, pyridine-IR and XPS analyses. Based on the optimal reaction condition (240°C, 4 h, 2.0 MPa H₂), various model compounds could also be effectively hydrotreated to produce corresponding products. A mechanistic study revealed that cyclohexanol and methylcyclohexane were major products for the transfer cleavage of BPE. Furthermore, it has been illustrated that aryl groups played a significant role in the hydrogenation of phenol from the competitive catalytic hydrogenation reaction of phenol. This study opened up the possibility of the valorization of lignin using a rare earth metal as the co-catalyst for the selective cleavage of lignin model compounds to value-added chems. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Name: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Name: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient Ni-based catalysts for the hydrotreatment of lignin dimer model compounds to cycloalkanes/cycloalkanols was written by Chen, Changzhou;Wu, Dichao;Liu, Peng;Xia, Haihong;Zhou, Minghao;Hou, Xinglong;Jiang, Jianchun. And the article was included in Reaction Chemistry & Engineering in 2021.Application of 103-16-2 The following contents are mentioned in the article:

The noble-metal catalytic cleavage of ether bonds in lignin to obtain aromatic chems. has achieved great success, and the development of a low-cost efficient catalyst is crucial. Herein, Ni_xLa_y/CNT was designed for the hydrogenolysis of benzyl Ph ether (BPE), di-Ph ether (DPE) and 2-phenethyl Ph ether (PPE) under a relatively mild condition. Owing to the synergistic effect of Ni with La, the Ni-La catalyst was especially active. Moreover, not only could the Ni-La catalyst fracture the C-O bond, but it could also transform aromatic rings to produce cycloalkanes. Physicochem. characterizations were carried out by means of XRD, TEM, H₂-TPR, NH₃-TPD, pyridine-IR and XPS analyses. Based on the optimal reaction condition (240°C, 4 h, 2.0 MPa H₂), various model compounds could also be effectively hydrotreated to produce corresponding products. A mechanistic study revealed that cyclohexanol and methylcyclohexane were major products for the transfer cleavage of BPE. Furthermore, it has been illustrated that aryl groups played a significant role in the hydrogenation of phenol from the competitive catalytic hydrogenation reaction of phenol. This study opened up the possibility of the valorization of lignin using a rare earth metal as the co-catalyst for the selective cleavage of lignin model compounds to value-added chems. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Evaluation of bioremediation and detoxification potentiality for papermaking black liquor by a new isolated thermophilic and alkali-tolerant Serratia sp. AXJ-M was written by An, Xuejiao;Zhong, Bin;Chen, Guotao;An, Weijuan;Xia, Xiang;Li, Hanguang;Lai, Fenju;Zhang, Qinghua. And the article was included in Journal of Hazardous Materials in 2021.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

There is a great need for efficiently treating papermaking black liquor because it can seriously pollute both soil and water ecosystems. In this study, the Plackett-Burman (PB) exptl. design combined with response surface methodol. (RSM) was used for improving the biodegradation efficiency of lignin by a new isolated thermophilic and alkali-tolerant strain Serratia sp. AXJ-M, and the results showed that a biodegradation efficiency of 70.5% was achieved under optimal culture conditions. The bacterium with ligninolytic activities significantly decreased target the parameters (color 80%, lignin 60%, phenol 95%, BOD 80% and COD 80%). The control and treated samples were analyzed by gas chromatog.-mass spectrometer (GC-MS), which showed that the concentrations of a majority of low-mol.-weight compounds were decreased after biol. treatment. Furthermore, toxicol., genotoxicity and phytotoxicity studies have supported the detoxification by the bacterium of black liquor. Finally, the genome sequence of the thermophilic, alkali-tolerant and lignin-degrading bacterium AXJ-M was completed, and the genetic basis of the thermophilic and alkali-resistant properties of AXJ-M was preliminarily revealed. The dyp-type peroxidase was first reported to have the potential to catalyze lignin degradation structurally. These findings suggest that Serratia sp. AXJ-M may be potentially useful for bioremediation applications for papermaking black liquor. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem