Category: ethers-buliding-blocks

Tetrahydrocurcumin Has Similar Anti-Amyloid Properties as Curcumin: In Vitro Comparative Structure-Activity Studies was written by Maiti, Panchanan;Manna, Jayeeta;Thammathong, Joshua;Evans, Bobbi;Dubey, Kshatresh Dutta;Banerjee, Souvik;Dunbar, Gary L.. And the article was included in Antioxidants in 2021.Related Products of 33171-05-0 The following contents are mentioned in the article:

Despite its potent anti-amyloid properties, the utility of curcumin (Cur) for the treatment of Alzheimer’s disease (AD) is limited due to its low bioavailability. Tetrahydrocurcumin (THC), a more stable metabolite has been found in Cur-treated tissues. We compared the anti-amyloid and neuroprotective properties of curcumin, bisdemethoxycurcumin (BDMC), demethoxycurcumin (DMC) and THC using mol. docking/dynamics, in-silico and in vitro studies. We measured the binding affinity, H-bonding capabilities of these compounds with amyloid beta protein (Aβ). Dot blot assays, photo-induced cross linking of unmodified protein (PICUP) and transmission electron microscopy (TEM) were performed to monitor the Aβ aggregation inhibition using these compounds Neuroprotective effects of these derivatives were evaluated in N2a, CHO and SH-SY5Y cells using Aβ42 (10μM) as a toxin. Finally, Aβ-binding capabilities were compared in the brain tissue derived from the 5x FAD mouse model of AD. We observed that THC had similar binding capability and Aβ aggregation inhibition such as keto/enol Cur and it was greater than BDMC and DMC. All these derivatives showed a similar degree of neuroprotection in vitro and labeled Aβ-plaques ex vivo. Overall, ECur and THC showed greater anti-amyloid properties than other derivatives Therefore, THC, a more stable and bioavailable metabolite may provide greater therapeutic efficacy in AD than other turmeric derivatives This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Related Products of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Related Products of 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reductive Catalytic Depolymerization of Semi-industrial Wood-Based Lignin was written by Lu, Xiaojia;Lagerquist, Lucas;Eranen, Kari;Hemming, Jarl;Eklund, Patrik;Estel, Lionel;Leveneur, Sebastien;Grenman, Henrik. And the article was included in Industrial & Engineering Chemistry Research in 2021.Recommanded Product: 2380-78-1 The following contents are mentioned in the article:

The current work studies the reductive catalytic depolymerization (RCD) of lignin from a novel semi-industrial process. The aim was to obtain aromatic mono-, di-, tri-, and tetramers for further valorization. The substrate and products were characterized by multiple anal. methods, including high pressure size-exclusion chromatog. (HPSEC), gas chromatog.-mass spectrometry, GC-flame ionization detector (FID), GC-FID/thermal conductivity detector (TCD), and NMR. The RCD was studied by exploring the influence of different parameters, such as lignin solubility, reaction time, hydrogen pressure, reaction temperature, pH, type and loading of the catalyst, as well as type and composition of the organic/aqueous solvent. The results show that an elevated temperature, a redox catalyst, and a hydrogen atm. are essential for the depolymerization and stability of the products, while the reaction medium also plays an important role. The highest obtained mono- to tetramers yield was 98% and mono- to dimers yield over 85% in the liquid phase products. The reaction mechanisms influenced the structure of the aliphatic chain in the monomers, but left the phenolic structure along with the methoxy groups largely unaltered. The current work contributes to the development and debottlenecking of the novel and sustainable overall process, which utilizes efficiently all the fractions of wood, in line with the principles of green engineering and chem. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Recommanded Product: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Recommanded Product: 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Protective effect of a novel polyherbal formulation on experimentally induced osteoarthritis in a rat model was written by Orhan, Cemal;Tuzcu, Mehmet;Durmus, Ali Said;Sahin, Nurhan;Ozercan, Ibrahim Hanifi;Deeh, Patrick Brice Defo;Morde, Abhijeet;Bhanuse, Prakash;Acharya, Manutosh;Padigaru, Muralidhara;Sahin, Kazim. And the article was included in Biomedicine & Pharmacotherapy in 2022.Name: Bisdemethoxycurcumin The following contents are mentioned in the article:

Osteoarthritis (OA) is a musculoskeletal disorder mainly found in elderly individuals. Modern treatment of OA, like nonsteroidal anti-inflammatory drugs, corticosteroids, hyaluronic acid injections, etc., is linked to long-term side effects. We evaluated the anti-osteoarthritic properties of a novel joint health formula (JHF) containing Bisdemethoxycurcumin enriched curcumin, 3-O-Acetyl-11-keto-beta-Boswellic acid-enriched Boswellia, and Ashwagandha in monosodium iodoacetate (MIA)-induced knee OA in rats. Twenty-eight female rats were distributed into four groups: Control, OA, OA + JHF (100 mg/kg), and OA + JHF (200 mg/kg). JHF decreased the right joint diameters but increased the paw area and stride length compared to the OA group with no treatment. JHF significantly reduced the arthritic conditions after four weeks of supplementation (p < 0.05). JHF significantly decreased TNF-α, IL-1β, IL-10, COMP, and CRP in the serum of osteoarthritic rats (p < 0.0001). We observed reduced lipid peroxidation but increased SOD, GSH-Px, and CAT activities in response to JHF treatment in OA animals. JHF down-regulated MMP-3, COX-2, and LOX-5 and improved the histol. structure of the knee joint of osteoarthritic rats. JHF demonstrated a protective effect against osteoarthritis, possibly due to anti-inflammatory and antioxidant activity in exptl. induced osteoarthritis in rats, and could be an effective option in the management of OA. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Name: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: Bisdemethoxycurcumin

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hydrothermal Co-Liquefaction of Synthetic Polymers and Miscanthus giganteus: Synergistic and Antagonistic Effects was written by Souza dos Passos, Juliano;Glasius, Marianne;Biller, Patrick. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.SDS of cas: 103-16-2 The following contents are mentioned in the article:

Synthetic polymers constitute one of the main carbon-containing wastes generated nowadays. In this study, combined hydrothermal liquefaction (co-HTL) is evaluated for 1:1 mixtures of Miscanthus giganteus and different synthetic polymers-including poly-acrylonitrile-butadiene-styrene (ABS), bisphenol-A-based epoxy resin, high-d. polyethylene (HDPE), low-d. polyethylene (LDPE), polyamide 6 (PA6), polyamide 6/6 (PA66), poly(ethylene terephthalate) (PET), polycarbonate (PC), polypropylene (PP), polystyrene (PS), and polyurethane foam (PUR)-using batch HTL at 350°C. Based on oil yields and composition, a comprehensive discussion of observed interactions is presented. The results show that even though polyolefins do not depolymerize under these conditions, the oil products depict that these materials interact with miscanthus biocrude changing its composition Bisphenol-A-based polymers as PC and epoxy resins both contribute to the formation of monomer-like structures in the biocrude. PET increases the presence of carboxyl groups, while polyamides and PUR increase significantly the oil yield, modifying the biocrude composition toward nitrogen-containing mols. PUR co-HTL was found to increase oil, carbon, and energy yields, leading to process improvement when compared to pure miscanthus processing. HTL of synthetic polymers and biomass can be an opportunity for sustainable recycling of chems. in a synergistic, multipurpose process. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2SDS of cas: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hydrothermal Co-Liquefaction of Synthetic Polymers and Miscanthus giganteus: Synergistic and Antagonistic Effects was written by Souza dos Passos, Juliano;Glasius, Marianne;Biller, Patrick. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.HPLC of Formula: 103-16-2 The following contents are mentioned in the article:

Synthetic polymers constitute one of the main carbon-containing wastes generated nowadays. In this study, combined hydrothermal liquefaction (co-HTL) is evaluated for 1:1 mixtures of Miscanthus giganteus and different synthetic polymers-including poly-acrylonitrile-butadiene-styrene (ABS), bisphenol-A-based epoxy resin, high-d. polyethylene (HDPE), low-d. polyethylene (LDPE), polyamide 6 (PA6), polyamide 6/6 (PA66), poly(ethylene terephthalate) (PET), polycarbonate (PC), polypropylene (PP), polystyrene (PS), and polyurethane foam (PUR)-using batch HTL at 350°C. Based on oil yields and composition, a comprehensive discussion of observed interactions is presented. The results show that even though polyolefins do not depolymerize under these conditions, the oil products depict that these materials interact with miscanthus biocrude changing its composition Bisphenol-A-based polymers as PC and epoxy resins both contribute to the formation of monomer-like structures in the biocrude. PET increases the presence of carboxyl groups, while polyamides and PUR increase significantly the oil yield, modifying the biocrude composition toward nitrogen-containing mols. PUR co-HTL was found to increase oil, carbon, and energy yields, leading to process improvement when compared to pure miscanthus processing. HTL of synthetic polymers and biomass can be an opportunity for sustainable recycling of chems. in a synergistic, multipurpose process. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2HPLC of Formula: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

LC-QTOF-MS identification of major urinary cyclopropylfentanyl metabolites using synthesized standards was written by Vikingsson, Svante;Rautio, Tobias;Wallgren, Jakob;Strand, Anna;Watanabe, Shimpei;Dahlen, Johan;Wohlfarth, Ariane;Konradsson, Peter;Wu, Xiongyu;Kronstrand, Robert;Green, Henrik. And the article was included in Journal of Analytical Toxicology in 2019.HPLC of Formula: 2380-78-1 The following contents are mentioned in the article:

The aim of this studywas to provide the exact structure of abundant and unique metabolites of cyclopropylfentanyl along with synthesis routes. In this study, metabolites were identified in 13 post-mortem urine samples using liquid chromatog- raphy quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). Samples were analyzed with and without enzymic hydrolysis, and seven potential metabolites were synthesized inhouse to provide the identity of major metabolites. Cyclopropylfentanyl was detected in all samples, and the most abundant metabolite was norcyclo- propylfentanyl (M1) that was detected in 12 out of 13 samples. Reference materials were synthesized (synthesis routes provided) to identify the exact structure of the major metabolites 4-hydroxyphenethyl cyclopropylfentanyl (M8), 3,4-dihydroxyphenethyl cyclopropylfentanyl (M5) and 4-hydroxy-3-methoxyphenethyl cyclopropylfentanyl (M9). These metabolites are suitable urinary markers of cyclopropylfentanyl intake as they are unique and detected in a majority of hydrolyzed urine samples. Minor metabolites included two quinone metabolites (M6 and M7), not previously reported for fentanyl analogs. Interestingly, with the exception of norcyclopropylfentanyl (M1), the metabolites appeared to be between 40% and 90% conjugated in urine. In total, 11 metabolites of cyclo- propylfentanyl were identified, including most metabolites previously reported after hepatocyte incubation. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1HPLC of Formula: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Evaluation of traditional ayurvedic Kadha for prevention and management of the novel Coronavirus (SARS-CoV-2) using in silico approach was written by Maurya, Dharmendra Kumar;Sharma, Deepak. And the article was included in Journal of Biomolecular Structure and Dynamics in 2022.Formula: C19H16O4 The following contents are mentioned in the article:

Since the emergence of novel Coronavirus (SARS-CoV-2) infection in Wuhan, China in Dec. 2019, it has now spread to over 205 countries. Considering the current state of affairs, there is an urgent unmet medical need to identify novel and effective approaches for the prevention and treatment of COVID-19 by re-evaluating the knowledge of traditional medicines and repurposing of drugs. Here, we used mol. docking and mol. dynamics simulation approach to explore the beneficial roles of phytochems. and active pharmacol. agents present in the Indian herbs which are widely used in the preparation of Ayurvedic medicines in the form of Kadha to control various respiratory disorders such as cough, cold and flu. Our study has identified an array of phytochems. present in these herbs which have significant docking scores and potential to inhibit different stages of SARS-CoV-2 infection as well as other Coronavirus target proteins. The phytochems. present in these herbs possess significant anti-inflammatory property. Apart from this, based on their pharmaceutical characteristics, we have also performed in-silico drug-likeness and predicted pharmacokinetics of the selected phytochems. found in the Kadha. Overall our study provides scientific justification in terms of binding of active ingredients present in different plants used in Kadha preparation with viral proteins and target proteins for prevention and treatment of the COVID-19. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Formula: C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C19H16O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Virtual screening of curcumin and its analogs against the spike surface glycoprotein of SARS-CoV-2 and SARS-CoV was written by Patel, Ashish;Rajendran, Malathi;Shah, Ashish;Patel, Harnisha;Pakala, Suresh B.;Karyala, Prashanthi. And the article was included in Journal of Biomolecular Structure and Dynamics in 2022.Name: Bisdemethoxycurcumin The following contents are mentioned in the article:

The novel corona virus SARS-CoV-2 and the 2002 SARS-CoV have 74% identity and use similar mechanisms to gain entry into the cell. Both the viruses enter the host cell by binding of the viral spike glycoprotein to the host receptor, angiotensin converting enzyme 2 (ACE2). Targeting entry of the virus has a better advantage than inhibiting the later stages of the viral life cycle. The crystal structure of the SARS-CoV (6CRV: full length S protein) and SARS-CoV-2 Spike proteins (6M0J: Receptor binding domain, RBD) was used to determine potential small mol. inhibitors. Curcumin, a naturally occurring phytochem. in Curcuma longa, is known to have broad pharmacol. properties. In the present study, curcumin and its derivatives were docked, using Autodock 4.2, onto the 6CRV and 6M0J to study their capability to act as inhibitors of the spike protein and thereby, viral entry. The curcumin and its derivatives displayed binding energies, ΔG, ranging from -10.98 to -5.12 kcal/mol (6CRV) and -10.01 to -5.33 kcal/mol (6M0J). The least binding energy was seen in bis-demethoxycurcumin with: ΔG = -10.98 kcal/mol (6CRV) and -10.01 kcal/mol (6M0J). A good binding energy, drug likeness and efficient pharmacokinetic parameters suggest the potential of curcumin and few of its derivatives as SARS-CoV-2 spike protein inhibitors. However, further research is necessary to investigate the ability of these compounds as viral entry inhibitors. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Name: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: Bisdemethoxycurcumin

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition was written by Xu, Shaohua;Fan, Ruolan;Wang, Lu;He, Weishen;Ge, Haixia;Chen, Hailan;Xu, Wen;Zhang, Jian;Xu, Wei;Feng, Yaqian;Fan, Zhimin. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2022.Formula: C3H9NO The following contents are mentioned in the article:

Using STAT3 inhibitors as a potential strategy in cancer therapy have attracted much attention. Recently, celastrol has been reported that it could directly bind to and suppress the activity of STAT3 in the cardiac dysfunction model. To explore more effective STAT3 inhibiting anti-tumor drug candidates, we synthesized a series of celastrol derivatives and biol. evaluated them with several human cancer cell lines. The western blotting anal. showed that compound3-Hydroxy-9b,13a-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid 2-(2-thienyl) ethylamide,the most active derivative, could suppress the STAT3s phosphorylation as well as its downstream genes. SPR anal., mol. docking and dynamics simulations results indicated that the 3-Hydroxy-9b,13a-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid 2-(2-thienyl) ethylamide could bind with STAT3 protein more tightly than celastrol. Then we found that the 3-Hydroxy-9b,13a-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid 2-(2-thienyl) ethylamide could block cell-cycle and induce apoptosis on HCT-116 cells. Furthermore, the anti-tumor effect of 3-Hydroxy-9b,13a-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid 2-(2-thienyl) ethylamide was verified on colorectal cancer organoid. This is the first research that discovered effective STAT3 inhibitors as potent anti-tumor agents from celastrol derivatives This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors was written by Kharbanda, Anupreet;Zhang, Lingtian;Saha, Debasmita;Tran, Phuc;Xu, Ke;Li, Ming O.;Leung, Yuet-Kin;Frett, Brendan;Li, Hong-yu. And the article was included in European Journal of Medicinal Chemistry in 2021.COA of Formula: C3H9NO The following contents are mentioned in the article:

TGFβ is crucial for the homeostasis of epithelial and neural tissues, wound repair, and regulating immune responses. Its dysregulation is associated with a vast number of diseases, of which modifying the tumor microenvironment is one of vital clin. interest. Despite various attempts, there is still no FDA-approved therapy to inhibit the TGFβ pathway. Major mainstream approaches involve impairment of the TGFβ pathway via inhibition of the TGFβRI kinase. With the purpose to identify non-receptor kinase-based inhibitors to impair TGFβ signaling, an inhouse chem. library was enriched, through a computational study, to eliminate TGFβRI kinase activity. Selected compounds were screened against a cell line engineered with a firefly luciferase gene under TGFβ-Smad-dependent transcriptional control. Results indicated moderate potency for a mol. with phthalazine core against TGFβ-Smad signaling. A series of phthalazine compounds were synthesized and evaluated for potency. The most promising compound I exhibited an IC₅₀ of 0.11 ± 0.02μM and was confirmed to be non-cytotoxic up to 12μM, with a selectivity index of approx. 112-fold. Simultaneously, I was confirmed to reduce the Smad phosphorylation using Western blot without exhibiting inhibition on the TGFβRI enzyme. This study identified a novel small-mol. scaffold that targets the TGFβ pathway via a non-receptor-kinase mechanism. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3COA of Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem