Category: ethers-buliding-blocks

Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity was written by Eric, Slavica;Ke, Song;Barata, Teresa;Solmajer, Tom;Antic Stankovic, Jelena;Juranic, Zorica;Savic, Vladimir;Zloh, Mire. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Product Details of 562085-85-2 The following contents are mentioned in the article:

A set of 16 previously synthesized aryl-aminopyridine and aryl-aminoquinoline derivatives have been evaluated for cytotoxic activity against three cancer cell lines (human cervical cancer-HeLa; human chronic myeloid leukemia-K562; human melanoma-Fem-x) and two types of normal peripheral blood mononuclear cells, with and without phytohemagglutinin (PBMC – PHA; PBMC + PHA). Twelve of the studied compounds showed moderate cytotoxicity, with selectivity against K562 but not the remaining two cancer cell lines. Four compounds were not active in cytotoxicity assays, presumably due to high predicted lipophilicity and low solubility To rationalize the observed cytotoxic effects, structure-based virtual screening was carried out against a pool of potential targets constructed using the inverse docking program Tarfisdock and bibliog. references The putative targets were identified on the basis of the best correlation between docking scores and in vitro cytotoxicity. It is proposed that the mechanism of action of the studied aminopyridines involves the disruption of signaling pathways and cancer cell cycle through the inhibition of cyclin-dependent kinases and several tyrosine kinases, namely Bcr-Abl kinase and KIT receptor kinase. The obtained results can guide further structural modifications of the studied compounds aimed at developing selective agents targeting proteins involved in cancer cell survival and proliferation. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Product Details of 562085-85-2).

N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 562085-85-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Morphologies of three-phase emulsions of the ternary nonionic amphiphile/oil/water systems and their determination by electrical method was written by Lee, Jong-Moon;Shin, Hong-Ju;Lim, Kyung-Hee. And the article was included in Journal of Colloid and Interface Science in 2003.Electric Literature of C10H22O3 The following contents are mentioned in the article:

Equations were developed for the elec. and thermal conductivities of dispersions of 2 different phases of low conductivity in a 3rd, conductive phase. These equations predict the conductivity of the dispersion from the volume fractions and conductivities of the constituent phases. Elec. conductivity measurements on dispersions of 3 liquid phases, i.e., 3-phase emulsions, were made over a wide range of volume fractions of each dispersed phase and used to test the equations. The equations predict accurately dispersion conductivities from the measured volume fractions and conductivities of the constituent phases without any adjustable parameters. The predicted values are in excellent agreement with the measured conductivities of 3-phase emulsions in the nonionic amphiphile/oil/H₂O systems. This leads to the determination of 3-phase emulsion morphologies. When the ratio K_d of the emulsion-drop conductivity to the continuous phase conductivity is O(10^-1)<K_d<1, the elec. method yields the correct morphol. When K_d≪1, the equations predicted several morphologies, but the correct morphol. can be chosen when the data are supplemented by another method such as microscopy. The elec. method, which is a combination of conductivity measurements and their fits to the equations, was proven to be effective and reliable in determination of 3-phase dispersion morphologies. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Electric Literature of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

TOC removal of diethylene glycol mono-n-hexyl ether synthetic wastewater and 1,4-butanediol diglycidyl ether synthetic wastewater with H₂O₂/UV in a batch reactor was written by Hou, Wei-Jie;Tsuneda, Satoshi;Hirata, Akira. And the article was included in Journal of Chemical Engineering of Japan in 2001.Category: ethers-buliding-blocks The following contents are mentioned in the article:

Removal of diethylene glycol mono-n-hexyl ether (DGME) or 1,4-butanediol diglycidyl ether (BDE) from wastewater by H₂O₂/UV was studied. Experiments were carried out in a batch reactor with a low pressure UV lamp (500 W) irradiating UV at 254 nm and at 185 nm (5% of energy). Complete TOC removals were obtained. TOC removals were pseudo-1st-order processes. The removal rates of TOC were governed by the concentration of H₂O₂ added initially and the maximum pseudo-1st-order rate constant and the optimum initial H₂O₂ concentration existed both in the wastewater. The relation between the initial TOC concentration and the optimum initial H₂O₂ concentration exhibited linear in both wastewaters. The optimum initial H₂O₂ concentration in the TOC removal of the BDE wastewater is higher than that of the DGME wastewater at a given initial TOC concentration The maximum pseudo-1st-order rate constant increases with the decrease in the initial TOC concentration in both wastewaters. The maximum pseudo-1st-order rate constant for the DGME wastewater is higher than that for the BDE wastewater at a given initial TOC concentration The exptl. results agree well with the theor. consideration which has been previously proposed by authors when H₂O₂ and TOC concentrations in the wastewater were very high. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Category: ethers-buliding-blocks).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solid State Inclusion of the Nonionic Surfactant C₁₂E₄ in β-Cyclodextrin, at Various Humidities: A Combined Raman and ¹³C CP MAS NMR Study was written by Cunha-Silva, Luis;Teixeira-Dias, Jose J. C.. And the article was included in Journal of Physical Chemistry B in 2002.Synthetic Route of C10H22O3 The following contents are mentioned in the article:

The inclusion of the nonionic surfactant α-n-dodecyl-ω-hydroxytetra(oxyethylene), C₁₂E₄, in β-cyclodextrin (β-CD), was prepared in the solid state and its structure characterized by powder x-ray diffraction, thermogravimetry, and Raman and ¹³C CP/MAS NMR spectroscopies. Stepwise dehydration was observed in the thermogram, indicating the presence of energetically distinct water mols. Comparison of the dispersions of ¹³C chem. shift values for C1 and C4 atoms of the β-CD macrocycle, within a series of inclusion compounds of C_nE_m homologues, reveals a rather complete symmetrization of the β-CD macrocycle, and the dispersions of ¹³C shifts for C6 atoms point to the particular sensitivity of these atoms to hydrogen-bonding type of interactions. The integrated intensity of the O-H Raman stretching band for the β-CD inclusion compound of C₁₂E₄ is approx. constant for humidities between 20% and 80%. In passing from 15% to 20% of humidity, one observes abrupt relative intensity variations of some Raman bands, in particular at 926 cm^-1, and the sudden decrease of the dispersions of ¹³C chem. shift values for all carbon atoms of the β-CD macrocycle. Overall, the above findings converge to stress the structural relevance of hydration water in the β-CD inclusion compound of C₁₂E₄. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Synthetic Route of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Study the lipidoid nanoparticle mediated genome editing protein delivery using 3D intestinal tissue model was written by Yang, Tao;Han, Haobo;Chen, Ying;Yang, Liu;Parker, Rachael;Li, Yamin;Kaplan, David L.;Xu, Qiaobing. And the article was included in Bioactive Materials in 2021.Safety of 2-Methoxyethylamine The following contents are mentioned in the article:

Lipid nanoparticles are promising carriers for oral drug delivery. For bioactive cargos with intracellular targets, e.g. gene-editing proteins, it is essential for the cargo and carrier to remain complexed after crossing the epithelial layer of intestine in order for the delivery system to transport the cargos inside targeted cells. However, limited studies have been conducted to verify the integrity of cargo/carrier nanocomplexes and their capability in facilitating cargo delivery intracellularly after the nanocomplex crossing the epithelial barrier. Herein, we used a traditional 2D transwell system and a recently developed 3D tissue engineered intestine model and demonstrated the synthetic lipid nanoparticle (carrier) and protein (cargo) nanocomplexes are able to cross the epithelial layer and deliver the protein cargo inside the underneath cells. We found that the EC16-63 LNP efficiently encapsulated the GFP-Cre recombinase, penetrated the intestinal monolayer cells in both the 2D cell culture and 3D tissue models through temporarily interrupting the tight junctions between epithelial layer. After transporting across the intestinal epithelia, the EC16-63 and GFP-Cre recombinase nanocomplexes can enter the underneath cells to induce gene recombination. These results suggest that the in vitro 3D intestinal tissue model is useful for identifying effective lipid nanoparticles for potential oral drug delivery. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Safety of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Identification of new antiviral agents against Kaposi’s sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation was written by Chen, Jungang;Dai, Lu;Goldstein, Alana;Zhang, Haiwei;Tang, Wei;Forrest, J. Craig;Post, Steven R.;Chen, Xulin;Qin, Zhiqiang. And the article was included in PLoS Pathogens in 2019.Recommanded Product: 103-16-2 The following contents are mentioned in the article:

In this study, we have established a high-throughput screening assay by using an inducible KSHV+ cell-line, iSLK.219. After screening a compound library that consisted of 1280 Food and Drug Administration (FDA)-approved drugs, 15 hit compounds that effectively inhibited KSHV virion production were identified, most of which have never been reported with anti-KSHV activities. Interestingly, 3 of these drugs target histamine receptors or signaling. Our data further confirmed that antagonists targeting different histamine receptors (HxRs) displayed excellent inhibitory effects on KSHV lytic replication from induced iSLK.219 or BCBL-1 cells. In contrast, histamine and specific agonists of HxRs promoted viral lytic replication from induced iSLK.219 or KSHVinfected primary cells. Mechanistic studies indicated that downstream MAPK and PI3K/Akt signaling pathways were required for histamine/receptors mediated promotion of KSHV lytic replication. Direct knockdown of HxRs in iSLK.219 cells effectively blocked viral lytic gene expression during induction. Using samples from a cohort of HIV+ patients, we found that the KSHV+ group has much higher levels of histamine in their plasma and saliva than the KSHV- group. Taken together, our data have identified new anti-KSHV agents and provided novel insights into the mol. bases of host factors that contribute to lytic replication and reactivation of this oncogenic herpesvirus. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Recommanded Product: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Preparation of biomass-based gas separation membranes from biochar residue obtained by depolymerization of lignin with ZSM-5 to promote a circular bioeconomy was written by He, Dongpo;Xu, Jingyu;Yang, Yingying;Zhu, Hongwei;Yu, Mengtian;Li, Shengnan;Xu, Shuangping;Zhou, Jinghui;Wang, Xing. And the article was included in International Journal of Biological Macromolecules in 2022.Synthetic Route of C9H12O3 The following contents are mentioned in the article:

Reuse of biochar residues after lignin degradation will not only save costs but also reduce the pollution, protect and improve the environment. In this study, biochar residue (BR) after peanut shell lignin selective depolymerization on ZSM-5 were recycled, and characterized by SEM, surface area and pore size distribution analyzers, TGA. Subsequently, a series of hybrid matrix membranes were prepared using Et cellulose as the matrix and biochar residue after depolymerization under different reaction conditions as the filler.separation performance of BR/EC membranes for CO₂/CH₄ mixed gas and CO₂/N₂ mixed gas was measured. The results showed that the gas separation membranes prepared with biochar residue (3 h, 300°C) as filler had good gas separation characteristics. The resulting mixed-matrix membrane exhibited a permeability of 66.00 Barrer for CO₂ and selectivities of 9.97 for CO₂/CH₄. Meanwhile, the resulting mixed-matrix membrane exhibited a permeability of 79.53 Barrer for CO₂ and selectivities of 20.01 for CO₂/N₂. Both exceed the upper limit of known pure EC membranes. Therefore, the use of biochar residue after ZSM-5 depolymerization as a filler for gas separation membranes is a feasible way. Furthermore, the membrane is well stabilized, proving its good potential for industrial applications. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Synthetic Route of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tetrafluorophenylene-Containing Vinylbenzyl Ether-Terminated Oligo(2,6-dimethyl-1,4-phenylene ether) with Better Thermal, Dielectric, and Flame-Retardant Properties for Application in High-Frequency Communication was written by Chen, Yi-Chun;Reddy, Kamani Sudhir K.;Lin, Yu-An;Wang, Meng-Wei;Lin, Ching-Hsuan. And the article was included in ACS Omega in 2022.COA of Formula: C13H12O2 The following contents are mentioned in the article:

In an integrated circuit, signal propagation loss is proportional to the frequency, dissipation factor (D_f), and square root of dielec. constant (D_k). The loss becomes obvious as we move to high-frequency communication. Therefore, a polymer having low D_k and D_f is critical for copper-clad laminates at higher frequencies. For this purpose, a 4-vinylbenzyl ether phenoxy-2,3,5,6-tetrafluorophenylene-terminated OPE (VT-OPE) resin was synthesized and its properties were compared with the thermoset of com. OPE-2St resin. The thermoset of VT-OPE shows a higher T_g (242 vs. 229°C), a relatively high crosslinking d. (1.59 vs. 1.41 mmole cm^-3), a lower coefficient of thermal expansion (55 vs. 76 ppm/°C), better dielec. characteristic at 10 GHz (D_k values of 2.58 vs. 2.75, D_f values of 0.005 vs. 0.006), lower water absorption (0.135 vs. 0.312 weight %), and better flame retardancy (UL-94 VTM-0 vs. VTM-1 with dropping seriously) than the thermoset of OPE-2St. To verify the practicability of VT-OPE for copper-clad laminate, a laboratory process was also performed to prepare a copper-clad laminate, which shows a high peeling strength with copper foil (5.5 lb/in), high thermal reliability with a solder dipping test at 288°C (>600 s), and the time for delamination of the laminate in thermal mech. anal. (TMA) at 288°C is over 60 min. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2COA of Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.COA of Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tetrafluorophenylene-Containing Vinylbenzyl Ether-Terminated Oligo(2,6-dimethyl-1,4-phenylene ether) with Better Thermal, Dielectric, and Flame-Retardant Properties for Application in High-Frequency Communication was written by Chen, Yi-Chun;Reddy, Kamani Sudhir K.;Lin, Yu-An;Wang, Meng-Wei;Lin, Ching-Hsuan. And the article was included in ACS Omega in 2022.Safety of 4-Benzyloxyphenol The following contents are mentioned in the article:

In an integrated circuit, signal propagation loss is proportional to the frequency, dissipation factor (D_f), and square root of dielec. constant (D_k). The loss becomes obvious as we move to high-frequency communication. Therefore, a polymer having low D_k and D_f is critical for copper-clad laminates at higher frequencies. For this purpose, a 4-vinylbenzyl ether phenoxy-2,3,5,6-tetrafluorophenylene-terminated OPE (VT-OPE) resin was synthesized and its properties were compared with the thermoset of com. OPE-2St resin. The thermoset of VT-OPE shows a higher T_g (242 vs. 229°C), a relatively high crosslinking d. (1.59 vs. 1.41 mmole cm^-3), a lower coefficient of thermal expansion (55 vs. 76 ppm/°C), better dielec. characteristic at 10 GHz (D_k values of 2.58 vs. 2.75, D_f values of 0.005 vs. 0.006), lower water absorption (0.135 vs. 0.312 weight %), and better flame retardancy (UL-94 VTM-0 vs. VTM-1 with dropping seriously) than the thermoset of OPE-2St. To verify the practicability of VT-OPE for copper-clad laminate, a laboratory process was also performed to prepare a copper-clad laminate, which shows a high peeling strength with copper foil (5.5 lb/in), high thermal reliability with a solder dipping test at 288°C (>600 s), and the time for delamination of the laminate in thermal mech. anal. (TMA) at 288°C is over 60 min. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Safety of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Potential of Thai herbal extracts on lung cancer treatment by inducing apoptosis and synergizing chemotherapy was written by Poofery, Juthathip;Khaw-on, Patompong;Subhawa, Subhawat;Sripanidkulchai, Bungorn;Tantraworasin, Apichat;Saeteng, Somcharoen;Siwachat, Sopon;Lertprasertsuke, Nirush;Banjerdpongchai, Ratana. And the article was included in Molecules in 2020.Name: 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

The incidence of lung cancer has increased while the mortality rate has continued to remain high. Effective treatment of this disease is the key to survival. Therefore, this study is a necessity in continuing research into new effective treatments. In this study we determined the effects of three different Thai herbs on lung cancer. Bridelia ovata, Croton oblongifolius, and Erythrophleum succirubrum were extracted by Et acetate and 50% ethanol. The cytotoxicity was tested with A549 lung cancer cell line. We found four effective extracts that exhibited toxic effects on A549 cells. These extracts included Et acetate extracts of B. ovata (BEA), C. oblongifolius (CEA), and E. succirubrum (EEA), and an ethanolic extract of E. succirubrum (EE). Moreover, these effective extracts were tested in combination with chemotherapeutic drugs. An effective synergism of these treatments was found specifically through a combination of BEA with methotrexate, EE with methotrexate, and EE with etoposide. Apoptotic cell death was induced in A549 cells by these effective extracts via the mitochondria-mediated pathway. Addnl., we established primary lung cancer and normal epithelial cells from lung tissue of lung cancer patients. The cytotoxicity results showed that EE had significant potential to be used for lung cancer treatment. In conclusion, the four effective extracts possessed anticancer effects on lung cancer. The most effective extract was found to be E. succirubrum (EE). This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Name: 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem