Category: ethers-buliding-blocks

Development and clinical trials on anti-inflammatory effect of transdermal patch containing a combination of Kaempferia parviflora and Curcuma longa extracts was written by Tuntiyasawasdikul, Sarunya;Sripanidkulchai, Bungorn. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Electric Literature of C19H16O4 The following contents are mentioned in the article:

Kaempferia parviflora and Curcuma longa have been widely reported to have a potent anti-inflammatory effect. However, both extracts have been shown to have low bioavailability and high-level first pass metabolism upon oral administration. This study aimed to develop transdermal delivery of a combination of both extracts in matrix-patch formulations with five different volatile oils which possess analgesic and anti-inflammatory properties. Fourteen formulations exhibited good physicochem. properties and stability. The release of methoxyflavones increased significantly when the concentration of PVP (polyvinylpyrrolidone) in the patches increased. The drug release kinetics were best-fitted with the zero-order and Higuchi models, depending on the amount of PVP. When combined with Curcuma longa, the patch provided the highest accumulation of methoxyflavones and curcuminoids within the skin. In the clin., randomized controlled trial, a significant pain improvement was found after seven days of application on the pain area. The pain scores decreased from 5.84 ± 1.57 to 2.74 ± 1.37 and the mean pain pressure threshold increased significantly from 1.79 ± 0.51 N to 2.55 ± 0.41 N. Our results indicated that the developed herbal patches were useful for transdermal application and can be considered as an alternative treatment for pain relief, highlighted by a decrease in pain intensity and an increase in pain tolerance, without skin irritation. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Electric Literature of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C19H16O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Disposition of Dietary Polyphenols in Breast Cancer Patient’s Tumors, and Their Associated Anticancer Activity: The Particular Case of Curcumin was written by Avila-Galvez, Maria Angeles;Gonzalez-Sarrias, Antonio;Martinez-Diaz, Francisco;Abellan, Beatriz;Martinez-Torrano, Alejandro Jose;Fernandez-Lopez, Antonio Jose;Gimenez-Bastida, Juan Antonio;Espin, Juan Carlos. And the article was included in Molecular Nutrition & Food Research in 2021.Name: Bisdemethoxycurcumin The following contents are mentioned in the article:

Some polyphenol-derived metabolites reach human breast cancer (BC) tissues at concentrations that induce cell senescence. However, this is unknown for isoflavones, curcuminoids, and lignans. Here, their metabolic profiling in normal (NT) and malignant (MT) mammary tissues of newly-diagnosed BC patients and the tissue-occurring metabolite’s anticancer activity are evaluated. Patients (n = 26) consumed 3 capsules/day (turmeric, red clover, and flaxseed extracts plus resveratrol; 296.4 mg phenolics/capsule) from biopsy-confirmed diagnosis to surgery (5 ± 2 days) or did not consume capsules (n = 13). NT and MT, blood, and urine are analyzed by UPLC-QTOF-MS using targeted metabolomics. Anticancer activity was tested in MCF-7 and MDA-MB-231 BC cells. Mainly phase-II metabolites were detected (108, 84, 49, and 47 in urine, plasma, NT, and MT, resp.). Total metabolite concentrations reached 10.7 ± 11.1 and 2.5 ± 2.4μmol L^-1 in NT and MT, resp. Free curcumin, but not its glucuronide, was detected in the tissues (1.1 ± 1.8 and 0.2 ± 0.2μmol L^-1 in NT and MT, resp.). Breast tissue-occurring metabolite’s antiproliferation was mainly exerted in p53-wild-type MCF-7 cells by curcuminoids through cell cycle arrest, senescence, and apoptosis induction via p53/p21 induction, while isoflavone-derived metabolites exerted estrogenic-like activity. Curcuminoids could be coadjuvants that might help fight BC upon regular consumption. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Name: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: Bisdemethoxycurcumin

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient hydrodeoxygenation of phenolic compounds and raw lignin-oil under a temperature-controlled phase-transfer catalysis was written by Yang, Zhi;Luo, Bowen;Shu, Riyang;Tian, Zhipeng;Kang, Yu;Chen, Ying. And the article was included in Fuel in 2021.Recommanded Product: 103-16-2 The following contents are mentioned in the article:

An effective binary catalyst by using tungstic acid (H₂WO₄) and Ru/C was employed for the hydrodeoxygenation (HDO) of phenolic compounds and raw lignin-oil. H2WO4 was presented as solid at ambient temperature, but it dissolved at high temperature above 100°C and therefore functioned as an active homogeneous catalyst. This phenomenon resulted in a temperature-controlled phase-transfer behavior in the HDO of phenolic compounds An efficient HDO performance and an exceptional reusability for guaiacol HDO were presented by this bifunctional catalyst, which can be reused more than 10 times with guaiacol conversion and cyclohexane selectivity over 90%. The comparison of traditional liquid organic and mineral acids, as well as solid acids, with H₂WO₄ confirmed the outstanding catalytic performance of H₂WO₄ and highlighted the advantages of H₂WO₄ as a homogeneous catalyst. Besides guaiacol, other phenolic compounds including various monomers and dimers all exhibited good HDO results, with 100% conversion and cycloalkanes selectivity. Moreover, the raw lignin-oil can be efficiently deoxygenated under the catalysis of this bifunctional catalyst 99.3% content of hydrocarbons was obtained in the upgraded lignin-oil, which was promising to be used as fuel directly. This catalytic system has great potential for the industrial application of lignin-oil upgrade. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient hydrodeoxygenation of phenolic compounds and raw lignin-oil under a temperature-controlled phase-transfer catalysis was written by Yang, Zhi;Luo, Bowen;Shu, Riyang;Tian, Zhipeng;Kang, Yu;Chen, Ying. And the article was included in Fuel in 2021.Electric Literature of C13H12O2 The following contents are mentioned in the article:

An effective binary catalyst by using tungstic acid (H₂WO₄) and Ru/C was employed for the hydrodeoxygenation (HDO) of phenolic compounds and raw lignin-oil. H2WO4 was presented as solid at ambient temperature, but it dissolved at high temperature above 100°C and therefore functioned as an active homogeneous catalyst. This phenomenon resulted in a temperature-controlled phase-transfer behavior in the HDO of phenolic compounds An efficient HDO performance and an exceptional reusability for guaiacol HDO were presented by this bifunctional catalyst, which can be reused more than 10 times with guaiacol conversion and cyclohexane selectivity over 90%. The comparison of traditional liquid organic and mineral acids, as well as solid acids, with H₂WO₄ confirmed the outstanding catalytic performance of H₂WO₄ and highlighted the advantages of H₂WO₄ as a homogeneous catalyst. Besides guaiacol, other phenolic compounds including various monomers and dimers all exhibited good HDO results, with 100% conversion and cycloalkanes selectivity. Moreover, the raw lignin-oil can be efficiently deoxygenated under the catalysis of this bifunctional catalyst 99.3% content of hydrocarbons was obtained in the upgraded lignin-oil, which was promising to be used as fuel directly. This catalytic system has great potential for the industrial application of lignin-oil upgrade. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Electric Literature of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient extracellular laccase secretion via bio-designed secretory apparatuses to enhance bacterial utilization of recalcitrant lignin was written by Cao, Lanfang;Lin, Lu;Sui, Haiyan;Wang, Heng;Zhang, Zhichao;Jiao, Nianzhi;Zhou, Jizhong. And the article was included in Green Chemistry in 2021.Synthetic Route of C9H12O3 The following contents are mentioned in the article:

Microbial-driven lignin conversion has a significant impact on the biogeochem. of global ecosystems and biomass utilization. During this process, secretion of extracellular ligninolytic enzymes is the first, essential step, yet there is a significant challenge to the secretion of these high-redox potential enzymes in bacteria, especially in Gram-neg. bacteria. In this study, genome and proteome analyses enabled us to bio-design two types of extracellular secretory apparatus, both of which effectively secreted a heterologous laccase in Pseudomonas putida, up to ~300 U mL-1. Importantly, a strong cooperation between P. putida A514 cells and the extracellular laccase, which was either released to the medium or displayed on the cell surface, was observed to significantly promote cell growth (9 x 1010 CFUs mL-1) and lignin consumption (12.5%). Chem. analyses of lignin further confirmed the effect on lignin utilization. Moreover, we demonstrated that a free laccase-A514 cell system exhibited greater effect on lignin utilization than that of a cell-immobilized laccase complex, which challenges the current view of bacterial polymer catabolism, and suggests the importance of secretory pathways and sufficient reaction surface for lignin biocatalysis. Our study advances the knowledge of secretion mechanisms in Gram-neg. bacteria and provides novel insights into the lignin utilization by extracellular lignolytic enzyme-bacterial cell systems. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Synthetic Route of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solubility of monobenzone in aqueous co-solvent mixtures of several alcohols: Determination, modelling and thermodynamic aspects analysis was written by Zhou, Yanyan;Wu, Jiaxin;Farajtabar, Ali;Wang, Jian;Zhao, Hongkun. And the article was included in Journal of Chemical Thermodynamics in 2020.Reference of 103-16-2 The following contents are mentioned in the article:

Investigation upon the solubility of monobenzone in aqueous co-solvent mixtures of isopropanol, n-propanol, ethylene glycol (EG) and ethanol was performed via a saturation shake-flask technique at temperatures from 283.15 K to 328.15 K under pressure of p = 101.2 kPa. Exptl. solubility magnitude presented pos. dependence upon the mass fraction of each co-solvent and temperature The greatest solubility value on the mole fraction scale was observed in the neat co-solvents. The equilibrated solids with corresponding co-solvent mixtures were characterized through an X-ray power diffraction (XRD) technique, demonstrating the absence of polymorphic transformation or solvate formation. The Jouyban-Acree model was adopted to math. describe the monobenzone solubility data. The maximum magnitudes of RAD and RMSD were 3.17 × 10^-2 and 7.64 × 10^-4, resp. The local mole fractions of isopropanol (n-propanol, EG or ethanol) and water adjacent monobenzone were quant. studied by the Inverse Kirkwood-Buff integrals method. The parameters of preferential solvation for the isopropanol (n-propanol, EG or ethanol) were pos. in the isopropanol (n-propanol, EG or ethanol) mixtures in intermediate and alc.-rich compositions, indicating that monobenzone was preferentially solvated by the isopropanol (n-propanol, EG or ethanol). Monobenzone mainly acted as a Lewis acid which interacted with proton-acceptor functional group of the alcs. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Reference of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solubility of monobenzone in aqueous co-solvent mixtures of several alcohols: Determination, modelling and thermodynamic aspects analysis was written by Zhou, Yanyan;Wu, Jiaxin;Farajtabar, Ali;Wang, Jian;Zhao, Hongkun. And the article was included in Journal of Chemical Thermodynamics in 2020.SDS of cas: 103-16-2 The following contents are mentioned in the article:

Investigation upon the solubility of monobenzone in aqueous co-solvent mixtures of isopropanol, n-propanol, ethylene glycol (EG) and ethanol was performed via a saturation shake-flask technique at temperatures from 283.15 K to 328.15 K under pressure of p = 101.2 kPa. Exptl. solubility magnitude presented pos. dependence upon the mass fraction of each co-solvent and temperature The greatest solubility value on the mole fraction scale was observed in the neat co-solvents. The equilibrated solids with corresponding co-solvent mixtures were characterized through an X-ray power diffraction (XRD) technique, demonstrating the absence of polymorphic transformation or solvate formation. The Jouyban-Acree model was adopted to math. describe the monobenzone solubility data. The maximum magnitudes of RAD and RMSD were 3.17 × 10^-2 and 7.64 × 10^-4, resp. The local mole fractions of isopropanol (n-propanol, EG or ethanol) and water adjacent monobenzone were quant. studied by the Inverse Kirkwood-Buff integrals method. The parameters of preferential solvation for the isopropanol (n-propanol, EG or ethanol) were pos. in the isopropanol (n-propanol, EG or ethanol) mixtures in intermediate and alc.-rich compositions, indicating that monobenzone was preferentially solvated by the isopropanol (n-propanol, EG or ethanol). Monobenzone mainly acted as a Lewis acid which interacted with proton-acceptor functional group of the alcs. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2SDS of cas: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.SDS of cas: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effect of storage time on the microbial and physicochemical properties of gamma irradiated turmeric powder under various atmospheres of packaging was written by Esmaeili, Saeideh;Berengi-Ardestani, Samira;Khanniri, Elham;Barzegar, Mohsen;Sahari, Mohammad Ali. And the article was included in Radiation Physics and Chemistry in 2021.Recommanded Product: Bisdemethoxycurcumin The following contents are mentioned in the article:

Irradiation process has recently found a special place in reducing microbial contamination of foodstuffs. However, there are still ambiguities about the effect of irradiation on the physicochem. properties and bioactive compounds of foods during storage. In this study, the influence of gamma irradiation at doses 0, 5, 10, and 15 kGy on the microbial load and physicochem. properties of turmeric powder were studied during one year storage at room temperature under air and modified atm. (vacuum and N2). The results showed that irradiation effectively reduced the microbial contamination of turmeric powder and it could provide the safety and microbial desirability of the samples for 1 yr at 10 kGy dose. By increasing the storage time and progress of oxidation processes, phenolic compounds (PCs) decreased in all samples. Subsequently, the curcumin, dimethoxycurcumin and bisdemethoxycurcumin contents as curcuminoids were diminished 61.5, 62.1, and 59.1% after one year of storage, resp. The IC50 (DPPH·, FRAP, and ABTS·+) of the extracts were in the range of (117.9-244.5μg/mL), (41.5-85.3μg/mL), and (206.4-505.2μg/mL), resp. during 12 mo of storage and the highest antioxidant activity of the extracts was obtained after four months of storage at a dose of 10 kGy (p < 0.05). These results confirm that the effect of storage time on the physicochem. properties of turmeric powder was higher than the effect of irradiation and packaging atm. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Recommanded Product: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Recommanded Product: Bisdemethoxycurcumin

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A Sensitive Spectrofluorimetric Method for Curcumin Analysis was written by Sravani, Anne Boyina;Mathew, Elizabeth Mary;Ghate, Vivek;Lewis, Shaila A.. And the article was included in Journal of Fluorescence in 2022.Computed Properties of C19H16O4 The following contents are mentioned in the article:

Curcumin (CUR), a natural polyphenolic compound extracted from the rhizomes of Curcuma longa, is used as a pharmaceutical agent, spice in food, and as a dye. Currently, CUR is being investigated for cancer treatment in Phase-II clin. trials. CUR also possesses excellent activities like anti-inflammatory, anti-microbial, and anti-oxidant, therefore quality control is crucial. The present research work was to develop a new, simple, validated and time-saving rapid 96-well plate spectrofluorimetric method for the determination of CUR. The developed method was compared with routinely used high performance liquid chromatog. (HPLC) technique. The developed method were found to be linear in the concentration range of 15 to 3900 ng/mL with R2 ≥ 0.9983 for spectrofluorimetric and 50-7500 ng/mL with R2 ≥ 0.9999 for HPLC method. Accuracy, intraday and interday precision was adequate, with RSD lower than the suggested limits. The limits for the detection and the quantification of CUR were 7 and 15 ng/mL for spectrofluorimetric, and 25 and 50 ng/mL for HPLC resp. The Bland-Altman anal. demonstrated the similarities between the two methods. The 96-well plate method was successfully applied to determine CUR in solid lipid nanoparticles (SLNs) and chitosan nanoparticles (Chi-NPs). The developed spectrofluorimetric method can hence serve as a possible replacement for the HPLC method for the quantification of CUR in healthcare and food products. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Computed Properties of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C19H16O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Impact of ultrasound-assisted extraction and solvent composition on bioactive compounds and in vitro biological activities of thyme and rosemary was written by Munekata, Paulo E. S.;Alcantara, Cristina;Zugcic, Tihana;Abdelkebir, Radhia;Collado, Maria Carmen;Garcia-Perez, Jose V.;Jambrak, Anet Rezek;Gavahian, Mohsen;Barba, Francisco J.;Lorenzo, Jose M.. And the article was included in Food Research International in 2020.HPLC of Formula: 2380-78-1 The following contents are mentioned in the article:

Mediterranean herbs, specially thyme and rosemary, are important ingredients in food preparation and more recently have been studied as natural sources of bioactive compounds This study aimed to study the effect of matrix (thyme vs. rosemary), and extraction protocol (conventional extraction vs. ultrasound assisted extraction) solvent composition (water vs. 50:50 ethanol:water solution) on the extraction of high value compounds (phenolic compounds, flavonoids and carotenoids) and also explore the antioxidant, antimicrobial (Listeria innocua, Staphylococcus aureus, and Salmonella enterica), probiotic (Lactobacillus casei and Bifidobacterium lactis), and anti-inflammatory activities. The phenolic, flavonoid and carotenoid content of extracts was greatly influenced by extraction conditions wherein the ultrasound pre-treatment improved the extraction of carotenoids but induced the opposite effect for polyphenols and flavonoids in both herbs. Only the aqueous extract of thyme obtained from ultrasound pre-treatment was the only extract that inhibited the growth of potentially pathogenic bacteria, stimulated the probiotic bacteria and achieved high anti-inflammatory and antioxidant activity. Moreover, this extract also was rich on phenolic compounds (such as p-coumaric acid 4-O-glucoside, kaempferol 3-O-rutinoside, feruloyl glucose, and 4-vinylguaiacol) and carotenoids. Therefore, ultrasound extraction of bioactive compounds with water as solvent could be explored in food and pharmaceutical applications. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1HPLC of Formula: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem