Ethers-buliding-blocks

Related Products of 592-55-2, The chemical industry reduces the impact on the environment during synthesis 592-55-2, name is 1-Bromo-2-ethoxyethane, I believe this compound will play a more active role in future production and life.

Potassium carbonate (2.43 g, 17.56 mmol) and ethyl bromoacetate (1.76 g, 10.54 mmol) were added to a solution of bis (2- (1- methylimidazolyl) methyl) amine(Lll) (1.8 g, 8.78 mmol) in dimethylfonnamide under an argon atmosphere. The resulting suspension was sheltered from light and allowed to stir at room temperature for 5 days. Water was added to the resulting mixture, and the solution was extracted with chloroform (3 x 50 mL). After the solvent was evaporated, the resulting oil was purified by silica gel column chromatography using a MeOH/CHC13 (5: 95) solution to giveLllEt as white powder. Yield: 1.05 g (41%). 1H NMR((ppm), MeOH-d4) : 6.87 (d, J) 1.2 Hz, 2H, ImH), 6.79(d, J) 1.2 Hz, 2H, ImH), 4.06 (q, J) 14.4 Hz, 2H,OCH2), 3.75 (s, 4H, ImCH2), 3.51 (s, 6H,NCH3), 3.35 (s, 2H, NCH2CO2), 1.19 (t, J) 7.2 Hz, 3H,CHs).”C NMR(b(ppm), MeOH-d4) : 172.09 (C,C02Et), 146.24 (2C, Im), 127.17 (2CH, Im), 123.79 (2CH, Im), 61.73 (C, OCH2), 55.03 (2C, ImCH2), 52.37 (2C,NCH3), 33.24 (C,NCH2), 14.67 (C, CH3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-ethoxyethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MOLECULAR INSIGHT PHARMACEUTICALS; WO2005/79865; (2005); A1;,
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Adding a certain compound to certain chemical reactions, such as: 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54149-17-6, Recommanded Product: 54149-17-6

A mixture of 5-nitro-1,2-dihydro-indazol-3-one (399 mg, 2.22 mmol), 1-bromo-2-(2-methoxy-ethoxy)-ethane (454 uL, 3.34 mmol), potassium iodide (370 mg, 2.22 mmol) and 1N sodium hydroxide solution (6.7 mL, 6.7 mmol) in 2 ml dioxane was stirred at 60 C. overnight. The reaction mixture was then cooled, poured into 50 mL H2O and 300 muL 10N NaOH was added. The aqueous layer was extracted with CH2Cl2 and then acidified to pH 2 with 6N HCl. The aqueous layer was extracted with ethyl acetate. The combined organic layer was dried over MgSO4, filtered and evaporated. The residue was purified by flash chromatography to afford the product 1-[2-(2-methoxy-ethoxy)-ethyl]-5-nitro-1,2-dihydro-indazol-3-one (380 mg, 61%). ES-MS calcd for C12H15N3O5 (m/e) 281.26, obsd 282.17 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-(2-methoxyethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bolin, David Robert; Cai, Jianping; Cheung, Adrian Wai-Hing; Goodnow, JR., Robert Alan; Hamilton, Matthew Michael; Li, Shiming; McDermott, Lee Apostle; Yun, Weiya; US2009/76275; (2009); A1;,
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Reference of 36865-41-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36865-41-5, name is 1-Bromo-3-methoxypropane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

NaH (60% suspension in mineral oil, 0.7 g, 17.6 mmol) was added to a solution of 1H-pyrazole (1.0 g, 14.7 mmol) in THF (50 mL) at 0 C. After stirring at 0 C for 0.5 h, 1-bromo-3-methoxypropane (1.6 mL, 17.6 mmol) was added. The mixture was allowed to warm to room temperature. After stirring at room temperature for 16 h, the reaction was quenched with saturated aqueous NH4C1. The mixture was poured into H20 (50 mL), and the aqueous phase was extracted with Et20. The organic phases were combined, washed withaqueous NaOH (1M), dried over Mg504, filtered, and concentrated under reduced pressure to afford the title compound (1.8 g, 88%).?H NMR (500 MHz, CDC13) oe ppm 2.10 – 2.18 (m, 2H), 3.30 – 3.32 (m, 2H), 3.33 (s, 3H), 4.28 (t, J=6.74 Hz, 2H), 6.27 (s, 1H), 7.42 (s, 1H), 7.55 (s, 1H)

The synthetic route of 1-Bromo-3-methoxypropane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PTC THERAPEUTICS, INC.; GERASYUTO, Aleksey, I.; ARNOLD, Michael, A.; CHEN, Guangming; KARP, Gary, Mitchell; QI, Hongyan; TURPOFF, Anthony, A.; WANG, Jiashi; WOLL, Matthew, G.; BRANSTROM, Arthur, A.; NARASIMHAN, Jana; DUMBLE, Melissa, L.; HEDRICK, Jean; WEETALL, Maria, L.; (374 pag.)WO2016/109706; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2398-37-0, name is 1-Bromo-3-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2398-37-0, HPLC of Formula: C7H7BrO

General procedure: The typical procedure is as follows. Oven dried Schlenk tube was equipped with stirrer bar, was charged with aryl halides (1 mmol), aryl phenylboronic acid (1.2 mmol), K2CO3 (2 mmol) and catalyst2 (3 mol %) in1:1 mixture of DMF/H2O medium. The reaction mixture was stirred in an oil bath at 100C in the presence of air. After completion of the reaction, the reaction mixture was then cooled to room temperature and diluted with Et2O/H2O (1:1, 20 mL). The organic layer was alienated and dried with anhydrous MgSO4. The product was filtered and dried under vacuum. The resulting crude compound was purified by column chromatography on silica gel to afford the corresponding products.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Nirmala, Muthukumaran; Arruri, Sathyanarayana; Vaddamanu, Moulali; Karupnaswamy, Ramesh; Mannarsamy, Maruthupandi; Adinarayana, Mannem; Ganesan, Prabusankar; Polyhedron; vol. 158; (2019); p. 125 – 134;,
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Adding a certain compound to certain chemical reactions, such as: 5961-59-1, name is 4-Methoxy-N-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5961-59-1, Recommanded Product: 5961-59-1

[[00146]] To a mixture of N-methyl-p-anisidine (2.8 g, 20 mmol) and malonic acid (4.3 g, 40 mmol) was added POC13 (17 mL). After heating at [90¡ã] C for 1.5 hr, the reaction mixture was poured over ice and basified with 6N [NAOH] to a pH of 14. The solution was then filtered and the filtrate was acidified with, 6N HC1 to pH 3. The precipitate was filtered and dried to afford a brown solid (1.8 g, [50percent). H] NMR (300 MHz, [MEOD-] d4) [8] 3.65 (3H, s), 3.86 (3H, s), 5.97 [(1H,] s), 7.28 [(1H,] dd, J [=] 2.8, 9.3 Hz), 7.49 (2H, d, J = 9.3 Hz).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Methoxy-N-methylaniline, and friends who are interested can also refer to it.

Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2003/106452; (2003); A2;,
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Application of 1535-73-5,Some common heterocyclic compound, 1535-73-5, name is 3-Trifluoromethoxyaniline, molecular formula is C7H6F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-(trifluoromethoxy)aniline (50.0 mg, 0.28 mmol), intermediate E (80.0 mg, 0.24 mmol), DMAP (1.5 mg, 0.01 mmol) and DIEA (62.0 mg, 0.48 mmol) in DMF (5 mL) was heated at 85¡ãC for 10h under N2. Water (10 mL) was added and the mixture was extracted with ethyl acetate (2 x 10 mL). The combined organics were dried over Na2SO4 , filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: DCM:MeOH = 15:1) to afford the titled compound (40.0 mg, 30percent) as a yellow solid. (0622) LCMS (method B): 2.66 min [MH]+=566.0. 1H NMR (400 MHz, DMSO-d6) delta 9.53 (s, 2H), 9.44-9.41 (m, 2H), 8.10 – 8.09 (m, 1 H),7.80 – 7.78 (m, 2H), 7.64 (dd, J = 8.4, 2.0 Hz, 1 H), 7.32 (br s, 1 H), 7.20 (br s, 1 H), 7.12-7.07 (m, 2H), 6.96 (d, J = 8.4 Hz, 2H), 6.65 (d, J = 8.4 Hz, 2H), 5.70 (d, J= 6.0 Hz, 1 H), 3.43 (s, 3H, covered), 2.74 (d, J = 3.9 Hz, 3H), 2.25 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Trifluoromethoxyaniline, its application will become more common.

Reference:
Patent; CATALYST THERAPEUTICS PTY LTD; LESSENE, Guillaume Laurent; GARNIER, Jean-Marc; CUZZUPE, Anthony Nicholas; FEUTRILL, John Thomas; CZABOTAR, Peter Edward; SHARMA, Pooja; (142 pag.)WO2016/127213; (2016); A1;,
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Reference of 109-85-3, The chemical industry reduces the impact on the environment during synthesis 109-85-3, name is 2-Methoxyethylamine, I believe this compound will play a more active role in future production and life.

Step 1 2-Chloro-5-nitropyridine (4.0 g) was stirred with 2-methoxyethylamine (20 mL) at room temperature for 1 h. The reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate (2*50 mL), washed with brine (20 mL), dried over sodium sulfate and evaporated under vacuum. The residue was washed with n-pentane (25 mL) to get N-(2-methoxyethyl)-5-nitropyridin-2-amine (4.8 g, 87%) as yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Gruenenthal GmbH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; US2013/29962; (2013); A1;,
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Application of 6876-00-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6876-00-2, name is 1-Bromo-3-phenoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 18 4-(4-Chlorophenyl)-2-fluoro-4-methyl-1-(3-phenoxyphenyl)pent-2-ene The method of Example 16 was repeated using a Grignard reagent, prepared from 3-phenoxyphenyl bromide (0.19 g), tetrahydrofuran (2 ml) and magnesium (22 g), and 4-(4-chlorophenyl)-2-fluoro-4-methylpent-2-enyl acetate (Example 13) (0.12 g). The residue after evaporation was purified by preparative thin layer chromatography (solvent: diethyl ether/hexane; 1:9) and then preparative high performance liquid chromatography (column: C18; solvent: methanol; flow rate: 3 ml/min; to give the title compound (38 mg, 22%).

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3-phenoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; British Technology Group, Ltd.; US5880162; (1999); A;,
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Adding a certain compound to certain chemical reactions, such as: 67191-35-9, name is 1-Isopropoxy-2-vinylbenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67191-35-9, Recommanded Product: 1-Isopropoxy-2-vinylbenzene

Under anhydrous and anaerobic conditions,Grubbs first generation catalyst 1a (1.22mmol)Add to a 100mL Schlenk bottle,Compound IIIaa (2858 mg, 2.43 mmol) andPotassium tert-butoxide (286 mg, 2.55 mmol)Add to the reaction bottle,Add 50 mL of n-hexane.After reacting at 60 C for 5 hours with stirring,TLC monitored the reaction completely.After the reaction was completed, n-hexane was removed under reduced pressure.The intermediate obtained in the previous step was dissolved in 40 mL of dichloromethane.Add cuprous chloride (300 mg, 1.42 mmol) and stir for 5 min.Compound 2a1 (296 mg, 1.82 mmol) was added to the reaction flask and the temperature was raised to 40 C.TLC monitored the reaction completely.After completion of the reaction, column chromatography gave 574 mg of light green solid powder IIaa1, yield: 32.3%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Isopropoxy-2-vinylbenzene, and friends who are interested can also refer to it.

Reference:
Patent; Chengdu Kaimeisi Business Wu Information Advisory Center (Limited Partner); Chen Jianxin; (28 pag.)CN110041262; (2019); A;,
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Related Products of 450-88-4, These common heterocyclic compound, 450-88-4, name is 1-Bromo-4-fluoro-2-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1 -bromo-4-fluoro-2-methoxybenzene (CAS No. [450-88-4]; 10.0 g, 48.8 mmol) in concentrated sulfuric acid (50 mL) was cooled to 0 C and treated dropwise with a freshly prepared mixture of fuming nitric acid (1.05 eq., 2.1 mL, 51 mmol) and concentrated sulfuric acid (1.85 eq., 4.8 mL, 90 mmol). The reaction mixture was stirred at 0 C for 30 minutes and poured in small portions on ice water. The formed precipitate was filtered off, washed with cold water and kept. The filtrate was extracted with ethyl acetate and the organic layer combined with the isolated precipitate. The organic layer was dried with sodium sulfate and concentrated in vacuo. The obtained material was purified by flash chromatography (Si02-hexane/ ethyl acetate) to give the title compound (5.88 g, 44%).1H-NMR (400MHz, DMSO-de): delta [ppm] = 4.00 (s, 3H), 7.44 (d, 1 H), 8.40 (d, 1 H).UPLC- MS (ESI-): [M – H] = 248/250; R, = 1.17 min (Br isotope pattern; Method E).

The synthetic route of 450-88-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; PANKNIN, Olaf; RING, Sven; ZIMMERMANN, Katja; NEUHAUS, Roland; (153 pag.)WO2017/9325; (2017); A1;,
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