Tag: 100-200

On March 20, 2020, Mi, Yan; Yao, Jiabin; Ma, Jingyu; Dai, Ling; Xiao, Chao; Wu, Wanhua; Yang, Cheng published an article.Electric Literature of 150-78-7 The title of the article was Fulleropillar[4]arene: The Synthesis and Complexation Properties. And the article contained the following:

A pillar[4]arene monoquinone (prepared by oxidation of permethylpillar[5]arene) underwent ring opening mediated by Cs2CO3 in DMF to yield the multihydroquinone ether dialdehyde I in 5% yield. The regioselective Prato reaction of I with fullerene C60-Ih and sarcosine yielded a trans-4 macrocyclic bisadduct as the major product in 12% yield. The fulleropillararene macrocycle formed a 1:1 complex with 4,4′-bis(dodecyl)-1,1′-bipyridinium dibromide with a binding constant of > 6500 M-1, a significantly stronger affinity than the binding of the viologen to either permethyl pillar[5]arene or the parent pillararene monoquinone. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Electric Literature of 150-78-7

The Article related to multihydroquinone ether aldehyde preparation, fullerene pillararene macrocycle regioselective preparation complexation viologen, base mediated ring opening pillararene, regioselective prato reaction c60 fullerene multihydroquinone ether aldehyde, complexation dodecylviologen fullerene pillararene macrocycle and other aspects.Electric Literature of 150-78-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

He, Jing; Yang, Zhen; Li, Weiwei; Wei, Yueting; Dai, Bin; Zhao, Jixing; Liu, Ping published their research in ChemCatChem in 2021. The article was titled 《Pd-Catalyzed N-Arylations of 3-Aryl-1-tosyl-1H-pyrazol-5-amines with Arylbromides and the Migration of Ts Group》.Safety of 1-Bromo-3-methoxybenzene The article contains the following contents:

An efficient palladium-catalyzed N-arylations of 3-aryl-1-tosyl-1H-pyrazol-5-amines with arylbromides was established. A series of diversified N-arylated products were obtained in excellent yields with broad substrate scope. Importantly, the N-arylated products undergo 1,4- and 1,6-migration reactions of Ts group under the action of Cs2CO3, affording the N-Ts-substituted pyrroles as major products (1,6-migration). Similar results was directly obtained by palladium-catalyzed reactions of 3-aryl-1-tosyl-1H-pyrazol-5-amines with arylbromides in the presence of Cs2CO3 as a base. Mechanistic studies reveal that the Ts-migration was achieved through an intermol. pathway. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Safety of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Safety of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Copper-Catalyzed One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1 H )-ones from 2-Nitrobenzonitriles and Carbonyl Compounds Mediated by Diboronic Acid in Methanol-Water》 was published in Synlett in 2020. These research results belong to Liu, Qixing; Sui, Yuebo; Zhang, Yin; Zhang, Kaili; Chen, Yongsheng; Zhou, Haifeng. Name: 2-(Benzyloxy)acetaldehyde The article mentions the following:

A copper-catalyzed one-pot synthesis of 2,3-dihydroquinazolin-4(1 H)-ones with diboronic acid as a reductant in an aqueous medium is described. Various 2,3-dihydroquinazolin-4(1 H)-ones were prepared with good functional-group tolerance in good yields under mild conditions from readily available 2-nitrobenzonitriles and various carbonyl compounds The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Name: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Name: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Ionic-Liquid-Modified Porous Au/CeMnOx Nanorods for Methyl Methacrylate (MMA) Synthesis via Direct Oxidative Esterification》 were Tian, Yun; Li, Yuchao; Zuo, Cuncun; Yin, Defeng; Wang, Ling; Zheng, Yanxia; Huang, Haofei; Fu, Zhongjun; Wang, Ming. And the article was published in ChemNanoMat in 2019. Synthetic Route of C8H8O2 The author mentioned the following in the article:

Porous MnCeOx solid solutions nanorods (PN-MnCeOx) with different pore sizes were prepared using different carbon chain lengths ionic liquids (C10mimCl, C12mimCl and C14mimCl). Series of novel catalysts with nano-Au supported on the PN-MnCeOx, were synthesized and applied to oxidative esterification of benzaldehydes to esters. Catalytic performance was evaluated in batch reactor and the relatively optimum catalyst was screened out. Kinds of characterization methods, such as XRD, TEM, XPS and BET, were applied to analyze crystal plane, microstructure, sp. surface area, and porous structure of the catalysts and the structure-activity relationship could be reasonably explained. The cyclic stability of the catalyst was also tested more than 7 times using MAL and methanol for Me methacrylate synthesis via one step oxidative esterification. In the part of experimental materials, we found many familiar compounds, such as 2-Methoxybenzaldehyde(cas: 135-02-4Synthetic Route of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Synthetic Route of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formula: C5H13NO2In 2021 ,《New and practical synthesis of GS-441524, the key intermediate of remdesivir》 appeared in Heterocycles. The author of the article were Li, Bo; Wang, Han; Sun, Cong; Lu, Sheng; Kang, LinLin; Jiang, Shun. The article conveys some information:

A new and practical synthesis of GS-441524, the key intermediate for remdesivir, is developed. 4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine is protected by DMF-DMA, and reacted with 2,3,5-tri-O-benzyl-D-ribonolactone to give the product in 61% isolated yield. The next cyanation and debenzylation are carried out at -30° successively in 67% yield over two steps with >99% purity (HPLC). Purification methods of the intermediates and the final product involved in the route are developed. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Formula: C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sau, Miriam; Pericas, Miquel A.; Martin, Ruben published an article in 2022. The article was titled 《Pd-Catalyzed Arylation of 1,2-Amino Alcohol Derivatives via β-Carbon Elimination》, and you may find the article in Synlett.COA of Formula: C7H7BrO The information in the text is summarized as follows:

Herein, authors describe a Pd-catalyzed arylation of 1,2-amino alcs. with aryl halides enabled by a retroallylation manifold. This protocol constitutes a new entry point to β-arylated aldehydes via the intermediacy of in situ generated enamine intermediates. The protocol is characterized by its exquisite regioselectivity profile and broad substrate scope – including challenging substrate combinations – even in an enantioselective manner. In the experiment, the researchers used 1-Bromo-3-methoxybenzene(cas: 2398-37-0COA of Formula: C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.COA of Formula: C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis of Unsymmetric Triarylmethanes Bearing CF3-Substituted All-Carbon Quaternary Stereocenters: 1,6-Arylation of δ-Trifluoromethyl Substituted para-Quinone Methides》 was published in Synlett in 2020. These research results belong to Ma, Yingang; Pang, Jingxiang; Pan, Xiaoguang; Ma, Shutao; Liu, Xigong; Liu, Lei. Formula: C7H8O2 The article mentions the following:

Pre-synthesized δ-CF3-δ-aryl-disubstituted para-quinone methides bearing δ-substituents were identified as isolable and storable substrates for 1,6-arylation reactions. A broad range of electron-rich arenes and heteroarenes participated in the arylation process, furnishing a wide array of unsym. CF3-substituted triarylmethanes in high efficiency. The mild and expeditious protocol exhibited broad scopes of both arene and para-quinone methide components. In the experimental materials used by the author, we found m-Methoxyphenol(cas: 150-19-6Formula: C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneFormula: C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Catalytic Asymmetric Synthesis of syn Aldols with Methyl Ketone Functionality and anti Aldols with a Thioamide Group》 were Ota, Yuya; Li, Zhao; Kumagai, Naoya; Shibasaki, Masakatsu. And the article was published in Synlett in 2019. Application In Synthesis of 2-(Benzyloxy)acetaldehyde The author mentioned the following in the article:

Catalytic asym. synthesis of syn aldols I [R = (CH2)6CH3, CH2OBn, (CH2)7OBz, etc.] with a Me ketone functionality were studied to confirm the generality of the methodol. In addition, catalytic asym. synthesis of anti aldols II [R1 = Et, i-Pr, c-hex, etc.] with a thioamide group was carefully examined, giving the desired products, albeit with moderate diastereoselectivity. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application In Synthesis of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Application In Synthesis of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 2398-37-0In 2019 ,《A Concise Enantioselective Synthesis of (S)-Preclamol via Asymmetric Catalytic Negishi Cross-Coupling Reaction》 appeared in Synlett. The author of the article were Zhou, Yun; Liu, Chunxiao; Wang, Lifeng; Han, Leng; Hou, Shicong; Bian, Qinghua; Zhong, Jiangchun. The article conveys some information:

A novel, concise, and efficient enantioselective synthesis of (S)-preclamol (87% ee, 51% total yield) has been developed. The key steps of this synthetic approach included cobalt-catalyzed asym. catalytic cross-coupling of α-bromo ester with arylzinc and the reduction of chiral ester to diol with a tertiary carbon atom. Moreover, it was demonstrated that our enantioselective Negishi cross-coupling was a powerful tool to construct stereogenic benzylmethyl center in chiral drugs on a gram scale. The experimental process involved the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Recommanded Product: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Visualization of endogenous β-galactosidase activity in living cells and zebrafish with a turn-on near-infrared fluorescent probe》 was published in Talanta in 2020. These research results belong to Pang, Xiao; Li, Yaqian; Zhou, Zile; Lu, Qiujun; Xie, Ruihua; Wu, Cuiyan; Zhang, Youyu; Li, Haitao. Synthetic Route of C8H8O3 The article mentions the following:

β-Galactosidase (β-gal) is an important biomarker for primary ovarian cancers. Developing noninvasive bioimaging probes for studying the activity of β-gal is highly desirable for cancer diagnosis. Herein, a turn-on near-IR (NIR) fluorescent probe, 2-((6-(((2S, 3R, 4S, 5R, 6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran -2-yl)oxy)-2,3-dihydro-1H-xanthen-4-yl)methylene)malononitrile named DXM-βgal, was rationally designed based on enzymic reaction for the detection of β-gal activity both in vitro and in vivo. Upon incubating with β-gal, DXM-βgal displayed a significant fluorescence enhancement at 640 nm, accompanying by a color change of solution color from red to purple. DXM-βgal exhibited high selectivity and sensitively to β-gal with low limit of detection (2.92 x 10-4 U mL-1). Besides, based on its advantages of long-wavelength emission and excellent biocompatibility, DXM-βgal was successfully applied to imaging β-gal in living cells and zebrafish. Given these prominent properties, we believe that DXM-βgal will be a potential tool for investigating β-gal activity in biomedical research. The results came from multiple reactions, including the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Synthetic Route of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Synthetic Route of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem