The author of 《Catalytic Asymmetric Synthesis of syn Aldols with Methyl Ketone Functionality and anti Aldols with a Thioamide Group》 were Ota, Yuya; Li, Zhao; Kumagai, Naoya; Shibasaki, Masakatsu. And the article was published in Synlett in 2019. Application In Synthesis of 2-(Benzyloxy)acetaldehyde The author mentioned the following in the article:
Catalytic asym. synthesis of syn aldols I [R = (CH2)6CH3, CH2OBn, (CH2)7OBz, etc.] with a Me ketone functionality were studied to confirm the generality of the methodol. In addition, catalytic asym. synthesis of anti aldols II [R1 = Et, i-Pr, c-hex, etc.] with a thioamide group was carefully examined, giving the desired products, albeit with moderate diastereoselectivity. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application In Synthesis of 2-(Benzyloxy)acetaldehyde)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Application In Synthesis of 2-(Benzyloxy)acetaldehyde
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem