He, Jing; Yang, Zhen; Li, Weiwei; Wei, Yueting; Dai, Bin; Zhao, Jixing; Liu, Ping published their research in ChemCatChem in 2021. The article was titled 《Pd-Catalyzed N-Arylations of 3-Aryl-1-tosyl-1H-pyrazol-5-amines with Arylbromides and the Migration of Ts Group》.Safety of 1-Bromo-3-methoxybenzene The article contains the following contents:
An efficient palladium-catalyzed N-arylations of 3-aryl-1-tosyl-1H-pyrazol-5-amines with arylbromides was established. A series of diversified N-arylated products were obtained in excellent yields with broad substrate scope. Importantly, the N-arylated products undergo 1,4- and 1,6-migration reactions of Ts group under the action of Cs2CO3, affording the N-Ts-substituted pyrroles as major products (1,6-migration). Similar results was directly obtained by palladium-catalyzed reactions of 3-aryl-1-tosyl-1H-pyrazol-5-amines with arylbromides in the presence of Cs2CO3 as a base. Mechanistic studies reveal that the Ts-migration was achieved through an intermol. pathway. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Safety of 1-Bromo-3-methoxybenzene)
1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Safety of 1-Bromo-3-methoxybenzene
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem