Tag: 100-200

In 2022,Wang, Zichen; Hao, Mingtian; Li, Xiaoyu; Zhang, Beibei; Jiao, Mingyang; Chen, Bo-Zhen published an article in iScience. The title of the article was 《Promising and efficient lignin degradation versatile strategy based on DFT calculations》.COA of Formula: C9H10O2 The author mentioned the following in the article:

The extraction of higher-value products from lignin degradations under mild conditions is a challenge. Previous research reported efficient two-step oxidation and reduction strategies for lignin degradation, which has great significance to lignin degradation In this paper, the mechanism about the C-O bond cleavage of lignin with and without Cα oxidations has been studied systematically. Our calculation results show that the degradation of anionized lignin with Cα oxidations is kinetically and thermodynamically feasible. In addition, the calculations predict that the anionized lignin compounds without Cα oxidation also could be degraded under mild conditions. Moreover, we propose special lignin catalytic degradation systems containing the characteristic structure of “”double hydrogen bonds””. The double hydrogen bonds structure could further decrease the energy barriers of the C-O bond cleavage reaction. This provides a versatile strategy to design novel lignin degradation In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).COA of Formula: C9H10O2

Referemce:
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Choi, Hosam; Jang, Hanho; Choi, Joohee; Lee, Kiyoun published their research in Molecules in 2021. The article was titled 《Stereoselective synthesis of oxazolidin-2-ones via an asymmetric aldol/Curtius reaction: concise total synthesis of (-)-cytoxazone》.COA of Formula: C9H10O2 The article contains the following contents:

An efficient approach toward the synthesis of 4,5-disubstituted oxazolidin-2-one scaffolds I [R1 = n-Bu, 2-thienyl, 4-ClC6H4, etc.] was reported. The developed approach was based on a combination of an asym. aldol and a modified Curtius protocol, which used an effective intramol. ring closure to rapidly access a range of oxazolidin-2-one building blocks. This strategy also permited a straightforward and concise asym. total synthesis of (-)-cytoxazone. Consisting of three steps, this was one of shortest synthesis reported to date. Ultimately, this convenient platform would provide a promising method for early phases of drug discovery. In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).COA of Formula: C9H10O2

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Ether – Wikipedia,
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《Nickel-catalyzed removal of alkene protecting group of phenols, alcohols via chain walking process》 was written by Meng, Chenkai; Niu, Haolin; Ning, Juehan; Wu, Wengang; Yi, Jun. Recommanded Product: m-Methoxyphenol And the article was included in Molecules in 2020. The article conveys some information:

An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alc. ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl group. The new reaction brings the homoallyl group into a start of new type of protecting group.m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Recommanded Product: m-Methoxyphenol

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Ether – Wikipedia,
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《An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging》 was published in Biomaterials in 2020. These research results belong to Zhou, Xiao; Li, Haidong; Shi, Chao; Xu, Feng; Zhang, Zhen; Yao, Qichao; Ma, He; Sun, Wen; Shao, Kun; Du, Jianjun; Long, Saran; Fan, Jiangli; Wang, Jingyun; Peng, Xiaojun. Application In Synthesis of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:

Photodynamic therapy has been developed as a prospective cancer treatment in recent years. Nevertheless, conventional photosensitizers suffer from lacking recognition and specificity to tumors, which causing severe side effects to normal tissues, while the enzyme-activated photosensitizers are capable of solving these conundrums due to high selectivity towards tumors. APN (Aminopeptidase N, APN/CD13), a tumor marker, has become a crucial targeting substance owing to its highly expressed on the cell membrane surface in various tumors, which has become a key point in the research of anti-tumor drug and fluorescence probe. Based on it, herein an APN-activated near-IR (NIR) photosensitizer (APN-CyI) for tumor imaging and photodynamic therapy has been firstly developed and successfully applied in vitro and in vivo. Studies showed that APN-CyI could be activated by APN in tumor cells, hydrolyzed to fluorescent CyI-OH, which specifically located in mitochondria in cancer cells and exhibited a high singlet oxygen yield under NIR irradiation, and efficiently induced cancer cell apoptosis. Dramatically, the in vivo assays on Balb/c mice showed that APN-CyI could achieve NIR fluorescence imaging (λem = 717 nm) for endogenous APN in tumors and possessed an efficient tumor suppression effect under NIR irradiation The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Application In Synthesis of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Application In Synthesis of 2-Hydroxy-4-methoxybenzaldehyde

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Synthetic Route of C7H8O2In 2022 ,《Design, Synthesis and Bioactivity Evaluation of Coumarin-BMT Hybrids as New Acetylcholinesterase Inhibitors》 was published in Molecules. The article was written by Zeng, Fanxin; Lu, Tao; Wang, Jie; Nie, Xuliang; Xiong, Wanming; Yin, Zhongping; Peng, Dayong. The article contains the following contents:

The compound bridge methylene tacrine (BMT) was synthesized, which has the classical pharmacophore structure of Tacrine (THA). Based on the principle of active substructure splicing, BMT was used as a lead compound and synthesized coumarin-BMT hybrids I [n = 5, 6, 7; R1 = H, Me, MeO, F3CO, Br; R2 = H, MeO] by introducing coumarin to BMT. In this work, 21 novel hybrids of BMT and coumarin I were synthesized and evaluated for their inhibitory activity on AChE. All obtained compounds I presented preferable inhibition. Compound I [n = 6, R1 = Me, R2 = H] was the most active compound, with the value of Ki as 49.2 nM, which was higher than Galantamine (GAL) and lower than THA. The result of mol. docking showed that the highest binding free energy was -40.43 kcal/mol for compound I [n = 6, R1 = Me, R2 = H] which was an identical trend with the calculated Ki. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Synthetic Route of C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Synthetic Route of C7H8O2

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Ether – Wikipedia,
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Formula: C5H13NO2In 2022 ,《Practical and Highly Efficient Synthesis of Remdesivir from GS-441524》 appeared in ACS Omega. The author of the article were Hu, Tianwen; Zhu, Fuqiang; Xiang, Li; Shen, Jingshan; Xie, Yuanchao; Aisa, Haji A.. The article conveys some information:

A three-step sequence for preparing remdesivir, an important anti-SARS-CoV-2 drug, is described. Employing N,N-dimethylformamide di-Me acetal (DMF-DMA) as a protecting agent, this synthesis started from (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-furan-2-carbonitrile (GS-441524) and consisted of three reactions, including protection, phosphoramidation, and deprotection. The advantages of this approach are as follows: (1) the protecting group could be removed under a mild deprotection condition, which avoided the generation of the degraded impurity; (2) high stereoselectivity was achieved in the phosphorylated reaction; (3) this synthesis could be performed successively without purification of intermediates. Moreover, the overall yield of this approach on a gram scale could be up to 85% with an excellent purity of 99.4% analyzed by high-performance liquid chromatog. (HPLC). The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Formula: C5H13NO2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application In Synthesis of 2-MethoxybenzaldehydeIn 2019 ,《Preparation and characterization of an eco-friendly ZnFe2O4@alginic acid nanocomposite catalyst and its application in the synthesis of 2-amino-3-cyano-4H-pyran derivatives》 appeared in Polyhedron. The author of the article were Maleki, Ali; Varzi, Zahra; Hassanzadeh-Afruzi, Fereshte. The article conveys some information:

The ZnFe2O4@alginic acid nanocomposite was synthesized by a simple procedure. Then, it was utilized as a green, cost-effective and heterogeneous catalyst in the synthesis of 2-amino-3-cyano-4H-pyran derivatives I (R = H, 2-NO2, 3-MeO, 4-OH, etc.) with a one-pot three-component reaction between various aromatic aldehydes RC6H4CHO, dimedone and malononitrile. Conventional methods such as Fourier transform IR (FT-IR) spectroscopy, X-ray diffraction (XRD) pattern, SEM (SEM) image, energy-dispersive X-ray (EDX) anal., vibrating sample magnetometer (VSM) curve and inductively-coupled plasma at. emission spectroscopy (ICP-AES) anal. were employed to characterize the prepared nanocomposite. This protocol offers some beneficial features such as green catalyst, mild reaction conditions, simple procedure, easy workup, short reaction times and significant yield of the products I. The magnetic properties of the nanocomposite caused its easy separation by using an external magnetic field from the reaction mixture without significant loss of its catalytic activity. In the experiment, the researchers used many compounds, for example, 2-Methoxybenzaldehyde(cas: 135-02-4Application In Synthesis of 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Application In Synthesis of 2-Methoxybenzaldehyde

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Ether – Wikipedia,
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In 2022,Ruan, Zhuwei; Wang, Min; Yang, Chen; Zhu, Lili; Su, Zhishan; Hong, Ran published an article in JACS Au. The title of the article was 《Total Synthesis of (+)-Hinckdentine A: Harnessing Noncovalent Interactions for Organocatalytic Bromination》.Product Details of 10365-98-7 The author mentioned the following in the article:

Synthesis of hinckdentine A, a marine-sponge-derived tribrominated indole alkaloid bearing a unique indolo[1,2-c]quinazoline skeleton, was completed in 12 steps featuring the construction of the α-quaternary carbon center by asym. azo-ene cyclization. A novel organocatalyst, e.g., 1-(3,5-bis-trifluoromethyl-phenyl)-3-[2-(diphenyl-phosphinothioyl)-phenyl]-thiourea was developed to promote high-yielding tribromination, which represents a challenging process encountered in previous syntheses. D. functional theory calculations scrutinized viable substrates and deciphered the origin of the enhancement of C8 electrophilic bromination with a bifunctional organocatalyst. Moreover, the application of organocatalyst-enabled bromination on various substrates such as 1H-indazole, 1-isothiocyanato-2,4-dimethoxybenzene, (2H-1,3-benzodioxol-5-yl)methanol, etc. was demonstrated to highlight future late functionalizations of biol. intriguing targets. In the part of experimental materials, we found many familiar compounds, such as 3-Methoxyphenylboronic acid(cas: 10365-98-7Product Details of 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Product Details of 10365-98-7

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In 2019,Synlett included an article by Kandula, Venu; Thota, Pradeep Kumar; Mallesham, Poosa; Raghavulu, K.; Chatterjee, Anindita; Yennam, Satyanarayana; Behera, Manoranjan. Synthetic Route of C5H13NO2. The article was titled 《Selectfluor-Mediated Tandem Cyclization of Enaminones for the Synthesis of 3-Fluorochromones》. The information in the text is summarized as follows:

An efficient synthesis of various 3-fluorochromones (3-fluoro-4H-chromene-4-ones) from enamino ketones by using Selectfluor was described. The key step in the synthesis involves tandem fluorination and cyclization to form 3-fluorochromones in good yields. The significant features of this method include simple operational procedures, a high purity of the product and excellent regioselectivity. In the part of experimental materials, we found many familiar compounds, such as N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Synthetic Route of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Synthetic Route of C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Synthesis included an article by Sang, Dayong; Tian, Juan; Tu, Xiaodong; He, Zhoujun; Yao, Ming. Related Products of 150-19-6. The article was titled 《Cleavage of Catechol Monoalkyl Ethers by Aluminum Triiodide-Dimethyl Sulfoxide》. The information in the text is summarized as follows:

Using eugenol and vanillin as model substrates, a practical method is developed for the cleavage o-hydroxyphenyl alkyl ethers. Aluminum oxide iodide (O=AlI), generated in situ from aluminum triiodide and DMSO, is the reactive ether cleaving species. The method is applicable to catechol monoalkyl ethers as well as normal Ph alkyl ethers for the removal of Me, Et, iso-Pr, and benzyl groups. A variety of functional groups such as alkenyl, allyl, amide, cyano, formyl, keto, nitro, and halogen are well tolerated under the optimum conditions. Partial hydrodebromination was observed during the demethylation of 4-bromoguaiacol, and was resolved using excess DMSO as an acid scavenger. This convenient and efficient procedure would be a practical tool for the preparation of catechols. The experimental process involved the reaction of m-Methoxyphenol(cas: 150-19-6Related Products of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRelated Products of 150-19-6

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Ether – Wikipedia,
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