Synthetic Route of C7H8O2In 2022 ,《Design, Synthesis and Bioactivity Evaluation of Coumarin-BMT Hybrids as New Acetylcholinesterase Inhibitors》 was published in Molecules. The article was written by Zeng, Fanxin; Lu, Tao; Wang, Jie; Nie, Xuliang; Xiong, Wanming; Yin, Zhongping; Peng, Dayong. The article contains the following contents:
The compound bridge methylene tacrine (BMT) was synthesized, which has the classical pharmacophore structure of Tacrine (THA). Based on the principle of active substructure splicing, BMT was used as a lead compound and synthesized coumarin-BMT hybrids I [n = 5, 6, 7; R1 = H, Me, MeO, F3CO, Br; R2 = H, MeO] by introducing coumarin to BMT. In this work, 21 novel hybrids of BMT and coumarin I were synthesized and evaluated for their inhibitory activity on AChE. All obtained compounds I presented preferable inhibition. Compound I [n = 6, R1 = Me, R2 = H] was the most active compound, with the value of Ki as 49.2 nM, which was higher than Galantamine (GAL) and lower than THA. The result of mol. docking showed that the highest binding free energy was -40.43 kcal/mol for compound I [n = 6, R1 = Me, R2 = H] which was an identical trend with the calculated Ki. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Synthetic Route of C7H8O2)
m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Synthetic Route of C7H8O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem