《An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging》 was published in Biomaterials in 2020. These research results belong to Zhou, Xiao; Li, Haidong; Shi, Chao; Xu, Feng; Zhang, Zhen; Yao, Qichao; Ma, He; Sun, Wen; Shao, Kun; Du, Jianjun; Long, Saran; Fan, Jiangli; Wang, Jingyun; Peng, Xiaojun. Application In Synthesis of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:
Photodynamic therapy has been developed as a prospective cancer treatment in recent years. Nevertheless, conventional photosensitizers suffer from lacking recognition and specificity to tumors, which causing severe side effects to normal tissues, while the enzyme-activated photosensitizers are capable of solving these conundrums due to high selectivity towards tumors. APN (Aminopeptidase N, APN/CD13), a tumor marker, has become a crucial targeting substance owing to its highly expressed on the cell membrane surface in various tumors, which has become a key point in the research of anti-tumor drug and fluorescence probe. Based on it, herein an APN-activated near-IR (NIR) photosensitizer (APN-CyI) for tumor imaging and photodynamic therapy has been firstly developed and successfully applied in vitro and in vivo. Studies showed that APN-CyI could be activated by APN in tumor cells, hydrolyzed to fluorescent CyI-OH, which specifically located in mitochondria in cancer cells and exhibited a high singlet oxygen yield under NIR irradiation, and efficiently induced cancer cell apoptosis. Dramatically, the in vivo assays on Balb/c mice showed that APN-CyI could achieve NIR fluorescence imaging (λem = 717 nm) for endogenous APN in tumors and possessed an efficient tumor suppression effect under NIR irradiation The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Application In Synthesis of 2-Hydroxy-4-methoxybenzaldehyde)
2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Application In Synthesis of 2-Hydroxy-4-methoxybenzaldehyde
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