Tag: 200-300

On October 12, 2006, Connolly, Stephen; Skrinjar, Marco published a patent.Reference of 3-(2-Methoxyphenoxy)benzaldehyde The title of the patent was Preparation of novel diazaspiroalkanes and their use for treatment of CCR8 mediated diseases. And the patent contained the following:

The title compounds I [R = pyridine N-oxide; R1 = II, III; R3 = OMe, OEt; R4 = H, OMe, OEt], useful in treating CCR8 mediated diseases such as asthma, COPD and rhinitis, were prepared E.g., a multi-step synthesis of IV, starting from tert-Bu 3,9-diazaspiro[5.5]undecane-3-carboxylate hydrochloride and 3-phenoxybenzaldehyde, was given. IV showed IC50 of 2.67 μM against human recombinant chemokine CCR8 receptor binding. Pharmaceutical compositions containing compounds I and their use in therapy are disclosed. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Reference of 3-(2-Methoxyphenoxy)benzaldehyde

The Article related to diazaspiroalkane diazaspiroundecane preparation chemokine ccr8 mediated disease treatment, antiasthmatic diazaspiroalkane diazaspiroundecane preparation, chronic obstructive pulmonary disease diazaspiroalkane diazaspiroundecane preparation, rhinitis diazaspiroalkane diazaspiroundecane preparation and other aspects.Reference of 3-(2-Methoxyphenoxy)benzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Copper-Catalyzed Methylthiolation of Aryl Iodides and Bromides with Dimethyl Disulfide in Water》 was published in Synlett in 2020. These research results belong to Wang, Ying-yu; Wu, Xiang-mei; Yang, Ming-hua. Recommanded Product: 1-Iodo-2-methoxybenzene The article mentions the following:

An efficient route to aryl Me sulfides through the copper-catalyzed coupling reaction of aryl iodides or bromides with di-Me disulfide in water was described. Electron-donating and electron-withdrawing functional groups in the substrates were tolerated, and the corresponding products were obtained in moderate to good yields. In the experimental materials used by the author, we found 1-Iodo-2-methoxybenzene(cas: 529-28-2Recommanded Product: 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Recommanded Product: 1-Iodo-2-methoxybenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Carbonylative Suzuki-Miyaura cross-coupling by immobilized Ni@Pd NPs supported on carbon nanotubes》 was published in RSC Advances in 2020. These research results belong to Nan, Liu; Cai, Yalan; Li, Jixiang; Ouyang, Dujuan; Duan, Wenhui; Rouhi, Jalal; Mustapha, Mazli. Safety of 1-Iodo-2-methoxybenzene The article mentions the following:

In this study, a novel carbon nanotube (CNT) based nanocatalyst (Ni@Pd/CNT) was synthesized by modifying CNTs using Ni@Pd core-shell nanoparticles (NPs). Ni@Pd/CNT was used in catalytic carbonylative cross-coupling between aryl iodides and phenylboronic acid to afford diaryl ketones ArC(O)Ph [Ar = Ph, 2-MeC6H4, 2-NH2C6H4, etc.]. The Ni@Pd NPs possessed a magnetic nickel (Ni) core with a palladium (Pd) structural composite shell. Thus, the use of Ni had led to a reduced consumption of Pd without sacrificing the overall catalytic performance, simultaneously making it reusable as it could be conveniently recovered from the reaction mixture by using an external magnetic field. Immobilization of the Ni@Pd NPs on carbon nanotubes not only prevented their aggregation, but also significantly enhanced the accessibility of the catalytically active sites. The above mentioned approach based on carbon nanotubes and Ni@Pd NPs provided a useful platform for the fabrication of noble-metal-based nanocatalysts with easy accessibility and low cost, which may allow for an efficient green alternative for various catalytic reductions In addition to this study using 1-Iodo-2-methoxybenzene, there are many other studies that have used 1-Iodo-2-methoxybenzene(cas: 529-28-2Safety of 1-Iodo-2-methoxybenzene) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Safety of 1-Iodo-2-methoxybenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《A Newly Designed Carbohydrate-Derived Alkylamine Promotes Ullmann Type C-N Coupling Catalyzed by Copper in Water》 were Zhou, Guoquan; Chen, Wen; Zhang, Shihui; Liu, Xuemin; Yang, Zehui; Ge, Xin; Fan, Hua-Jun. And the article was published in Synlett in 2019. Electric Literature of C7H7IO The author mentioned the following in the article:

In the presence of the diglucosylethanediamine I and CuI, aryl iodides underwent green Ullman-type coupling reactions with heterocyclic amines and aniline in water mediated by Cs2CO3 to yield N-arylated nitrogen heterocycles (particularly N-aryl imidazoles and indoles) and N-phenyl-p-anisidine. The solubility of 4-iodoanisole in water in the presence and absence of I was measured; I likely functions by both chelating copper and by promoting the dissolution of 4-iodoanisole in water. In addition to this study using 1-Iodo-2-methoxybenzene, there are many other studies that have used 1-Iodo-2-methoxybenzene(cas: 529-28-2Electric Literature of C7H7IO) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Electric Literature of C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,IUCrData included an article by Ramesh, V.; Rajarajan, K.; Gunasekaran, B.. Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane. The article was titled 《Bis(15-crown-5-κ5O)barium tetrakis(isothiocynato-κN)zinc(II)》. The information in the text is summarized as follows:

In the title compound, [Ba(C10H20O5)2][Zn(NCS)4], the 15-crown-5 mols. are disordered over two positions with site occupancies of 0.706 (4) and 0.294 (4). The Ba2+ ions are sandwiched between the 15-crown-5 rings and Zn2+ ions are surrounded by four N atoms from the thiocyanate ligands in a distorted tetrahedral geometry. The crystal studied was refined as an inversion twin. The experimental part of the paper was very detailed, including the reaction process of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Synlett included an article by Ni, Bang-qing; He, Yunpeng; Rong, Xuejiao; Niu, Teng-fei. Reference of 1,2-Diphenyldisulfane. The article was titled 《Molecular Iodine Catalyzed Hydroxysulfenylation of Alkenes with Disulfides in Aerobic Conditions》. The information in the text is summarized as follows:

An environmentally friendly and efficient strategy was developed for preparation β-hydroxy sulfides such as, R1C6H4SCHR2CR3R4OH [R1C6H4 = H, 4-Cl, 4-Me, etc.; R2 = H, Me, Ph; R3 = Ph, 4-BrC6H4, 2-naphthalenyl, etc.; R4 = H, Me, Ph] by a mol.-iodine-catalyzed radical reaction. This reaction involved hydroxysulfenylation of alkenes with disulfides in aqueous solution Air was used as the oxidant without any additives. Control experiments indicated that the oxygen atom of products might come from O2. Both aryl alkenes and aliphatic alkenes were well tolerated in this transformation and afforded the corresponding products in moderate to high yields. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7Reference of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Reference of 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formula: C12H10S2In 2021 ,《Green Aerobic Oxidation of Thiols to Disulfides by Flavin-Iodine Coupled Organocatalysis》 was published in Synlett. The article was written by Oka, Marina; Kozako, Ryo; Iida, Hiroki. The article contains the following contents:

Coupled catalysis using a riboflavin-derived organocatalyst and mol. iodine successfully promoted the aerobic oxidation of thiols to disulfides under metal-free mild conditions. The activation of mol. oxygen occurred smoothly at room temperature through the transfer of electrons from the iodine catalyst to the biomimetic flavin catalyst, forming the basis for a green oxidative synthesis of disulfides from thiols. In addition to this study using 1,2-Diphenyldisulfane, there are many other studies that have used 1,2-Diphenyldisulfane(cas: 882-33-7Formula: C12H10S2) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Formula: C12H10S2 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formula: C10H20O5In 2020 ,《Facilitate Gas Transport through Metal-Organic Polyhedra Constructed Porous Liquid Membrane》 appeared in Small. The author of the article were Deng, Zheng; Ying, Wen; Gong, Ke; Zeng, Yu-Jia; Yan, Youguo; Peng, Xinsheng. The article conveys some information:

Type II porous liquids are demonstrated to be promise porous materials. However, the category of porous hosts is very limited. Here, a porous host metal-organic polyhedra (MOP-18) is reported to construct type II porous liquids MOP-18 is dissolved into 15-crown-5 as an individual cage (5 nm). Both the mol. dynamics simulations and exptl. gravimetric CO2 solubility test indicate that the inner cavity of MOP-18 in porous liquids is unoccupied by 15-crown-5 and is accessible to CO2. Thus, the prepared porous liquids show enhanced gas solubility Furthermore, the prepared porous liquid is encapsulated into graphene oxide (GO) nanoslits to form a GO-supported porous liquid membrane (GO-SPLM). Owing to the empty cavity of MOP-18 unit cages in porous liquids that reduces the gas diffusion barrier, GO-SPLM significantly enhances the permeability of gas. After reading the article, we found that the author used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Formula: C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Formula: C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application In Synthesis of Bis(4-methoxyphenyl)amineIn 2019 ,《Spiro-Structure: A Good Approach to Achieve Mechanoluminescence Property》 was published in ACS Omega. The article was written by Liu, Fan; Tu, Zongxiao; Fan, Yunhao; Li, Qianqian; Li, Zhen. The article contains the following contents:

Following the development of organic mechanoluminescence (ML) materials, mol. packing was proved as the key point to the emission process under an external force. In this text, with the introduction of spiro-(fluorene-9-9′-xanthene) (SFX) unit as the building block, the mol. packing of the resultant compound (BSFXA) was optimized with the interlaced mode, directly leading to the efficient ML effect. The key role of SFX with a spiro-structure can be further confirmed by the ML inactivity of reference compound BFA with the replacement of SFX unit by di-Me fluorene (MeF), which provided a novel strategy to construct organic ML luminogens. The results came from multiple reactions, including the reaction of Bis(4-methoxyphenyl)amine(cas: 101-70-2Application In Synthesis of Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Application In Synthesis of Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Copper(I)-Catalyzed Thiolation of C-H Bonds for the Synthesis of Sulfenyl Pyrroles and Indoles》 were Xu, Wei; Hei, Yu-Yuan; Song, Jian-Lan; Zhan, Xin-Chen; Zhang, Xing-Guo; Deng, Chen-Liang. And the article was published in Synthesis in 2019. Name: 1,2-Diphenyldisulfane The author mentioned the following in the article:

A novel and convenient copper(I)-catalyzed thiolation of C-H bonds of pyrroles and indoles is developed for the synthesis of sulfenyl pyrroles I (RX= p-methylthiophenol, p-methoxythiophenol, p-nitrothiophrnol etc. Y= methylene, nitrogen) and indoles II (R= Hydrogen, 5-Me, 5-chloro etc. Y= methylene, nitrogen). Dual C-H thiolation reactions are observed for pyrroles. A wide range of pyrroles and indoles undergo the C-H thiolation smoothly with various disulfides and diselenides to generate the corresponding heteroaryl thioethers in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, 1,2-Diphenyldisulfane(cas: 882-33-7Name: 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Name: 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem