Tag: 200-300

Rh-Catalyzed Highly Enantioselective Synthesis of Aliphatic Sulfonyl Fluorides was written by Moku, Balakrishna;Fang, Wan-Yin;Leng, Jing;Li, Linxian;Zha, Gao-Feng;Rakesh, K. P.;Qin, Hua-Li. And the article was included in iScience in 2019.Formula: C13H12O2 The following contents are mentioned in the article:

Rh-catalyzed, highly enantioselective (up to 99.8% ee) synthesis of aliphatic sulfonyl fluorides (R)/(S)-RCH(R¹)CH₂SO₂F (R = Ph, dibenzo[b,d]thiophen-4-yl, thiophen-3-yl, etc.; R¹ = naphthalen-1-yl, dibenzo[b,d]furan-4-yl, benzo[b]thiophen-3-yl, etc.) was accomplished. This protocol provides a portal to a class of novel 2-aryl substituted chiral sulfonyl fluorides, which are otherwise extremely difficult to access. This asym. synthesis has the feature of mild conditions, excellent functional group compatibility, and wide substrate scope (51 examples) generating a wide array of structurally unique chiral β-arylated sulfonyl fluoride (R)-2-(dibenzo[b,d]thiophen-4-yl)-2-phenylethanesulfonyl fluoride for sulfur(VI) fluoride exchange (SuFEx) click reaction and drug discovery. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Micronization of Three Active Pharmaceutical Ingredients Using the Rapid Expansion of Supercritical Solution Technology was written by Fang, Chun-Hao;Chen, Pei-Hua;Chen, Yan-Ping;Tang, Muoi. And the article was included in Chemical Engineering & Technology in 2020.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

The rapid expansion of supercritical solution (RESS) technol. was applied to recrystallize and micronize three active pharmaceutical ingredients (APIs) of monobenzone, ethylparaben, and kojic acid. All unprocessed (original) APIs had a large mean particle size over 200μm with wide particle size distribution. Supercritical carbon dioxide served as the solvent to extract each API in a high-pressure vessel. The nearly saturated supercritical solution was then expanded through a capillary spray nozzle to ambient pressure state. The APIs were recrystallized in a very short time period. The final API particles with submicron sizes were obtained with much less intensity of crystallinity. The optimal RESS process parameters and the improved result of the in vitro dissolution test for the API of ethylparaben are reported. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Micronization of Three Active Pharmaceutical Ingredients Using the Rapid Expansion of Supercritical Solution Technology was written by Fang, Chun-Hao;Chen, Pei-Hua;Chen, Yan-Ping;Tang, Muoi. And the article was included in Chemical Engineering & Technology in 2020.Name: 4-Benzyloxyphenol The following contents are mentioned in the article:

The rapid expansion of supercritical solution (RESS) technol. was applied to recrystallize and micronize three active pharmaceutical ingredients (APIs) of monobenzone, ethylparaben, and kojic acid. All unprocessed (original) APIs had a large mean particle size over 200μm with wide particle size distribution. Supercritical carbon dioxide served as the solvent to extract each API in a high-pressure vessel. The nearly saturated supercritical solution was then expanded through a capillary spray nozzle to ambient pressure state. The APIs were recrystallized in a very short time period. The final API particles with submicron sizes were obtained with much less intensity of crystallinity. The optimal RESS process parameters and the improved result of the in vitro dissolution test for the API of ethylparaben are reported. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Name: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pyridine-based chiral smectogens: effects of polar end groups on liquid crystal properties was written by Vardar, Deniz;Akdas Kilic, Huriye;Ocak, Hale;Jeannin, Olivier;Camerel, Franck;Eran, Belkiz Bilgin. And the article was included in Liquid Crystals in 2021.COA of Formula: C13H12O2 The following contents are mentioned in the article:

In this study, novel chiral pyridine-based rod-like mesogens, consisting of a chloro or bromo group substituted pyridine head core which is connected to one or two aromatic rings through ester linkers and a flexible (S)-2-methylbutoxy or (S)-3,7-dimethyloctyloxy chiral end chain have been synthesized. The liquid crystal properties of new compounds were investigated by various exptl. techniques such as DSC, POM and SAXS. Depending of the nature of the halogen end group, the derivatives with two aromatic rings are non-mesogenic compounds whereas a smectic A phase (SmA) enantiotropically occurs for the members with three aromatic rings of the series. Addnl., chloro group substituted compound composed of three aromatic rings carrying a (S)-2-methylbutoxy end chain exhibits an enantiotropic chiral nematic phase (N*). This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2COA of Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pyridine-based chiral smectogens: effects of polar end groups on liquid crystal properties was written by Vardar, Deniz;Akdas Kilic, Huriye;Ocak, Hale;Jeannin, Olivier;Camerel, Franck;Eran, Belkiz Bilgin. And the article was included in Liquid Crystals in 2021.Formula: C13H12O2 The following contents are mentioned in the article:

In this study, novel chiral pyridine-based rod-like mesogens, consisting of a chloro or bromo group substituted pyridine head core which is connected to one or two aromatic rings through ester linkers and a flexible (S)-2-methylbutoxy or (S)-3,7-dimethyloctyloxy chiral end chain have been synthesized. The liquid crystal properties of new compounds were investigated by various exptl. techniques such as DSC, POM and SAXS. Depending of the nature of the halogen end group, the derivatives with two aromatic rings are non-mesogenic compounds whereas a smectic A phase (SmA) enantiotropically occurs for the members with three aromatic rings of the series. Addnl., chloro group substituted compound composed of three aromatic rings carrying a (S)-2-methylbutoxy end chain exhibits an enantiotropic chiral nematic phase (N*). This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

ortho- and meta-Selective C-H Activation and Borylation of Aromatic Aldehydes via in situ Generated Imines was written by Bisht, Ranjana;Chattopadhyay, Buddhadeb. And the article was included in Synlett in 2016.Formula: C14H19BO4 The following contents are mentioned in the article:

A ligand-controlled discovery of ortho and meta C-H borylation of aromatic aldehydes is described. In both cases, an amine is used and it was proposed that ortho borylation could be realized using tert-butylamine as the traceless protecting/directing group and meta borylation undergoes via an electrostatic interaction and a secondary interaction between the ligand of the iridium catalyst and the substrate. Remarkably, these electrostatic interactions and secondary B-N interactions offer a unique and unprecedented guiding factor for the meta-selective C-H activation/borylation of benzaldehydes. This is the first example for the C-H activation and functionalization where the ortho and meta position of a substrate has selectively been functionalized, which open a new chapter in electrophilic aromatic substitution. This study involved multiple reactions and reactants, such as 5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (cas: 1132669-90-9Formula: C14H19BO4).

5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (cas: 1132669-90-9) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C14H19BO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient and enantioselective total syntheses of heliannuols A and K was written by Kanematsu, Makoto;Soga, Kana;Manabe, Yuki;Morimoto, Sachie;Yoshida, Masahiro;Shishido, Kozo. And the article was included in Tetrahedron in 2011.Product Details of 100927-02-4 The following contents are mentioned in the article:

The second-generation enantioselective synthesis of (-)-heliannuol A (I) and the first enantioselective total synthesis of (-)-heliannuol K (II) via two routes have both been accomplished efficiently; (I, nine steps and 25% yield; II, seven steps and 47% yield). Highlights of our synthetic strategy include a substrate-controlled chirality transfer in the Lewis acid mediated Claisen rearrangement of the allyl aryl ether for the key construction of a tertiary stereogenic center at the benzylic position followed by, for I, ring-closing metathesis, diastereoselective epoxidation, and regioselective cleavage of the epoxide; and for II, ring-closing metathesis and conjugate reduction of the eight-membered enone. This study involved multiple reactions and reactants, such as 4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4Product Details of 100927-02-4).

4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 100927-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, functionalization, and isolation of planar-chiral pillar[5]arenes with bulky substituents using a chiral derivatization agent was written by Al-Azemi, Talal F.;Vinodh, Mickey;Alipour, Fatemeh H.;Mohamod, Abdirahman A.. And the article was included in RSC Advances in 2019.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

Bulky perneopentyloxy-pillar[5]arene (Pillar-1) I was synthesized and its conformational mobility was investigated using variable-temperature ¹H NMR spectroscopy. The host-guest interactions between Pillar-1 I and n-octyltrimethylammonium hexafluorophosphate (OMA) were investigated, and the formation of a 1 : 1 complex was revealed via¹H NMR. Planar-chiral isomers R/S II were synthesized via the reaction of a hydroxy-functionalized pillar[5]arene with chiral derivatization agent (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride. The (Sp, R)-and (Rp, R)-forms of the pillar[5]arene diastereomers R/S II were isolated by HPLC, and their structures were analyzed by ¹⁹F NMR. HPLC measurements indicated that racemization did not take place at 40 °C for 72 h. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient Stereoselective Carbocyclization to cis-1,4-Disubstituted Heterocycles Enabled by Dual Pd/Electron Transfer Mediator (ETM) Catalysis was written by Zhu, Can;Liu, Jie;Mai, Binh Khanh;Himo, Fahmi;Baeckvall, Jan-E.. And the article was included in Journal of the American Chemical Society in 2020.SDS of cas: 1003858-50-1 The following contents are mentioned in the article:

In the presence of Pd(OAc)₂ and a bis(hydroxyphenyl)salen cobalt complex acting as an electron transfer mediator, allylic enallenyl ethers such as I underwent diastereoselective tandem aerobic coupling and cyclization reactions with arylboronic acid neopentyl glycol esters to yield (arylmethyl)dialkenyldihydropyrans such as II and a dialkenyltetrahydropyridine as the cis-diastereomers in >8:1 dr. The mechanism of the reaction was studied using kinetic isotope effect (KIE) experiments, reactions of substrates with altered structures, and calculations of potential transition state structures and their energies; the alkene moiety of the eneallene is necessary both to facilitate C-H bond cleavage and to control product diastereoselectivity, while KIE indicated that C-H bond cleavage is the rate-limiting step. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1SDS of cas: 1003858-50-1).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.SDS of cas: 1003858-50-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, mesomorphic and dielectric properties of new bent-core liquid crystal with a terminal lactate group was written by Ocak, Hale;Canli, Nimet Yilmaz;Bilgin Eran, Belkiz. And the article was included in Journal of Molecular Structure in 2021.Computed Properties of C13H12O2 The following contents are mentioned in the article:

The synthesis, liquid crystalline properties and dielec. properties of a new bent-core compound (DBOB) composed of terephthalate based rod-like units with a O-dodecyl lactate group substituted at one side as well as n-octyloxy located at other terminal are presented. The liquid crystalline properties have been investigated by polarizing optical microscopy, differential scanning calorimetry and electro-optical studies. The dielec. parameters and phase regions of DBOB, which exhibits an enantiotropic non-polar SmA phase between 156 and 100° as well as SmA phase with a ferroelec. polar response at lower temperatures than 100°, have been carried out by impedance spectroscopy at different temperatures The dielec. relaxation mechanisms have been analyzed by Cole-Cole plots. The Debye distribution parameters and activation energies have also been determined This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Computed Properties of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem