Efficient and enantioselective total syntheses of heliannuols A and K was written by Kanematsu, Makoto;Soga, Kana;Manabe, Yuki;Morimoto, Sachie;Yoshida, Masahiro;Shishido, Kozo. And the article was included in Tetrahedron in 2011.Product Details of 100927-02-4 The following contents are mentioned in the article:
The second-generation enantioselective synthesis of (-)-heliannuol A (I) and the first enantioselective total synthesis of (-)-heliannuol K (II) via two routes have both been accomplished efficiently; (I, nine steps and 25% yield; II, seven steps and 47% yield). Highlights of our synthetic strategy include a substrate-controlled chirality transfer in the Lewis acid mediated Claisen rearrangement of the allyl aryl ether for the key construction of a tertiary stereogenic center at the benzylic position followed by, for I, ring-closing metathesis, diastereoselective epoxidation, and regioselective cleavage of the epoxide; and for II, ring-closing metathesis and conjugate reduction of the eight-membered enone. This study involved multiple reactions and reactants, such as 4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4Product Details of 100927-02-4).
4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 100927-02-4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem