Rh-Catalyzed Highly Enantioselective Synthesis of Aliphatic Sulfonyl Fluorides was written by Moku, Balakrishna;Fang, Wan-Yin;Leng, Jing;Li, Linxian;Zha, Gao-Feng;Rakesh, K. P.;Qin, Hua-Li. And the article was included in iScience in 2019.Formula: C13H12O2 The following contents are mentioned in the article:
Rh-catalyzed, highly enantioselective (up to 99.8% ee) synthesis of aliphatic sulfonyl fluorides (R)/(S)-RCH(R1)CH2SO2F (R = Ph, dibenzo[b,d]thiophen-4-yl, thiophen-3-yl, etc.; R1 = naphthalen-1-yl, dibenzo[b,d]furan-4-yl, benzo[b]thiophen-3-yl, etc.) was accomplished. This protocol provides a portal to a class of novel 2-aryl substituted chiral sulfonyl fluorides, which are otherwise extremely difficult to access. This asym. synthesis has the feature of mild conditions, excellent functional group compatibility, and wide substrate scope (51 examples) generating a wide array of structurally unique chiral β-arylated sulfonyl fluoride (R)-2-(dibenzo[b,d]thiophen-4-yl)-2-phenylethanesulfonyl fluoride for sulfur(VI) fluoride exchange (SuFEx) click reaction and drug discovery. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Formula: C13H12O2).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C13H12O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem