Tag: 200-300

Cheng, Faxiang; Ma, Haihong; Ren, Fengmei; Ouyang, Gaoyuan; Zhou, Zhengfa; Xu, Weibing published an article in 2010, the title of the article was Poly(2-methoxy-5-(2′-ethylhexyloxy)-p-phenylene vinylene) synthesized by bromine methylation.Product Details of 146370-51-6 And the article contains the following content:

Poly[2-methoxy-5-(2′-ethylhexyloxy)-p-phenylene vinylene] (MEH-PPV) was successfully synthesized using p-methoxy phenol and 1-bromo-2-ethylhexane through the reactions of etherification, bromine methylation and de-hydrogen bromide. The number average mol. weight of MEH-PPV was 5.7è„?04. The structure of intermediates and MEH-PPV were characterized by FTIR, 1HNMR and UV-Vis. The structure of intermediates and MEH-PPV was consistent with the reported in the literature. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Product Details of 146370-51-6

The Article related to methoxyethylhexyloxyphenylene vinylene bromine methylation synthesis, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Product Details of 146370-51-6

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Ether – Wikipedia,
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On October 9, 2008, Tomoo, Toshiyuki; Nakatsuka, Takashi; Hayashi, Yasuhiro; Katayama, Toyoko published a patent.Safety of Benzyl(4-bromophenyl)sulfane The title of the patent was Preparation of indole derivatives as cytosolic phospholipase A2 (cPLA2) inhibitors. And the patent contained the following:

The title compounds I [R1 = (un)substituted aromatic hydrocarbon group, (un)substituted aromatic heterocyclic group containing 1 – 4 heteroatoms (N, S, O), etc.; R2 = H, alkyl, cycloalkyl, etc.; R3 = (un)substituted aromatic hydrocarbon group, (un)substituted aromatic heterocyclic group containing 1 – 4 heteroatoms (N, S, O); R4 = cyano, tetrazole, isothiazole, etc.; X1 = carbonyl, methylene; X2 = alkylene, bond; X3 = alkylene, alkenylene, alkynylene] are prepared (2E)-3-(3-Benzoyl-1-phenyl-1H-indol-5-yl)-2-propenoic acid was prepared in a multistep process starting from 5-bromoindole and iodobenzene. Compounds of this invention showed IC50 values of 0.002 渭M to 21.3 渭M against cPLA2. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Safety of Benzyl(4-bromophenyl)sulfane

The Article related to indole derivative preparation cytosolic phospholipase a2 inhibitor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of Benzyl(4-bromophenyl)sulfane

Referemce:
Ether – Wikipedia,
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On May 20, 2016, Li, Pengfei; Weng, Yunxiang; Xu, Xianxiang; Cui, Xiuling published an article.Application of 157869-15-3 The title of the article was Access to Indole Derivatives from Diaryliodonium Salts and 2-Alkynylanilines. And the article contained the following:

An efficient, environmentally friendly, and operationally simple procedure to 1,2-disubstituted indoles from 2-alkynylanilines and diaryliodonium salts has been developed. This reaction proceeds smoothly under metal-free conditions. The products obtained could be transferred into 3,3′-diindolylmethane with DMSO catalyzed by palladium. The isotopic label experiments indicated that the methylene group in 3,3′-diindolylmethane is derived from DMSO. The diverse indoles were obtained in up to 90% yield for 28 examples. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Application of 157869-15-3

The Article related to indole preparation green chem, alkynylaniline diaryliodonium salt, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 157869-15-3

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Ether – Wikipedia,
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On May 8, 2003, Ghosh, Shomir; Patane, Michael A.; Carson, Kenneth G.; Chi, I-Cheng Shannon; Ye, Qing; Elder, Amy M.; Jenkins, Tracy J. published a patent.Synthetic Route of 66855-92-3 The title of the patent was Preparation of compounds as C-C chemokine receptor 8 antagonists, pharmaceutical compositions and use against inflammatory or viral disorders. And the patent contained the following:

The invention relates to (shown as I; variables defined below; e.g. 1-[1-(2′,6′-dichlorobiphenyl-3-ylmethyl)piperidin-4-yl]-1,3-dihydrobenzimidazol-2-one and 3-(3-phenoxybenzyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine). Preferred compounds are antagonists of C-C chemokine receptor 8 (no data). The invention also relates to a method for treating a subject having an inflammatory disorder or viral disorder comprising administering to a subject in need thereof an effective amount of a compound of the invention. Although the methods of preparation are not claimed, hundreds of example preparations are included. For I: L = O, S, NRa, a bond, SO2, C(O), and (CR’R”)m; Ra = H, (un)substituted alkyl, alkylaryl, and cycloalkyl; a is 0 to 3; b is 0 to 3; m is 1 to 8; R’ and R” = H, (un)substituted alkyl, cyano and (un)substituted alkenyl. R6, R7, R8, R9 and R10 = H, hydroxy, halogen, (un)substituted C1-C10 alkyl, (un)substituted C2-C10 alkenyl, (un)substituted C2-C10 alkynyl, (un)substituted C3-C10 cycloalkyl, (un)substituted C3-C10 cycloalkenyl, (un)substituted C3-C10 cycloalkynyl, (un)substituted C3-C10 cycloalkoxy, cyano, C1-C10 alkoxy, C2-C10 alkenyloxy, C2-C10 alkynyloxy, benzyloxy, (un)substituted amino, (un)substituted amido, O(CF3), C(O)O(R1), C(O)(R1), -SO2NR1R2, trifluoromethyl, aryl, aralkyl, heteroaryl and heteroaralkyl. R1 and R2 = H and (un)substituted alkyl; Q3 is (un)substituted alkyl; R11-R19 = H, hydroxy, halogen, (un)substituted alkyl, (un)substituted alkenyl, (un)substituted alkynyl, (un)substituted cycloalkyl, (un)substituted cycloalkenyl, (un)substituted cycloalkynyl, cyano, alkoxy, alkenyloxy, alkynyloxy, benzyloxy, (un)substituted amino, (un)substituted amido, O(CF3), C(O)O(R41), -C(O)(R41), -SO2NR41R42, trifluoromethyl, aryl, aralkyl, heteroaryl and heteroaralkyl; R41 and R42 = H, (un)substituted alkyl, (un)substituted alkenyl, (un)substituted alkynyl, (un)substituted cycloalkyl, (un)substituted cycloalkenyl, (un)substituted cycloalkynyl, (un)substituted amino, trifluoromethyl, aryl, aralkyl, heteroaryl and heteroaralkyl; or R41 and R42 may be linked via a C2-C8 (un)substituted alkyl or alkenyl bridge where â‰? carbons may be replaced by O, S or NR46. Q5 = -N(R20)C(O)(CR41R42)1-3-, 1-N(R20)C(O)cycloalkyl (ring size = 3-9), N(R20)C(O)-substituted azacycloalkyl; R20 and R46 = H, hydroxy, (un)substituted alkyl, (un)substituted alkenyl, (un)substituted alkynyl, (un)substituted cycloalkyl, optionally cycloalkenyl, (un)substituted cycloalkynyl, (un)substituted amino, (un)substituted amido, -C(O)O(R41), -C(O)(R41), -SO2NR4R42, trifluoromethyl, aryl, aralkyl, heteroaryl or heteroaralkyl; and Q6 = (un)substituted aromatic ring, (un)substituted nonaromatic heterocycle, and (un)substituted heteroaromatic ring; or R18 or R19 together with Q5Q6 and the atoms to which they are bonded form an (un)substituted nonaromatic carbocyclic group, (un)substituted nonaromatic heterocyclic group, (un)substituted aryl ring or (un)substituted heteroaryl ring. Addnl. details are given in the claims. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Synthetic Route of 66855-92-3

The Article related to ccr8 chemokine receptor antagonist preparation anti inflammatory antiviral agent, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Synthetic Route of 66855-92-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On June 26, 2014, Rooney, Lisa; Vidal, Agnes; D’Souza, Anne-Marie; Devereux, Nick; Masick, Brian; Boissel, Valerie; West, Ryan; Head, Victoria; Stringer, Rowan; Lao, Jianmin; Petrus, Matt J.; Patapoutian, Ardem; Nash, Mark; Stoakley, Natalie; Panesar, Moh; Verkuyl, J. Martin; Schumacher, Andrew M.; Petrassi, H. Michael; Tully, David C. published an article.Computed Properties of 152626-77-2 The title of the article was Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists. And the article contained the following:

A high throughput screening campaign identified 5-(2-chlorophenyl)indazole as an antagonist of the transient receptor potential A1 (TRPA1) ion channel with IC50 = 1.23 μM. Hit to lead medicinal chem. optimization established the SAR around the indazole ring system, demonstrating that a trifluoromethyl group at the 2-position of the Ph ring in combination with various substituents at the 6-position of the indazole ring greatly contributed to improvements in vitro activity. Further lead optimization resulted in the identification of compound I, a potent and selective antagonist of TRPA1 in vitro (IC50 = 0.015 μM), which has moderate oral bioavailability in rodents and demonstrates robust activity in vivo in several rodent models of inflammatory pain. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Computed Properties of 152626-77-2

The Article related to fluoromethylphenyl indazole transient receptor potential a1 ion channel antagonist, trpa1 antagonist discovery optimization sar analgesic, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 152626-77-2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 10, 2021, Doi, Hisashi; Watanabe, Yasuyoshi; Choi, Yilong; Kida, Tatsuya; Tateishi, Ukihide; Kano, Daisuke; Mori, Shigeyuki; Mori, Yasuo; Uesugi, Motonari published a patent.Synthetic Route of 152626-77-2 The title of the patent was Preparation of thiazole and indazole derivatives for visualizing TRPA1. And the patent contained the following:

The present invention provides thiazole and indazole derivatives I and II [R1 = a substituent having a radioisotope; R2 = a substituent having a radioisotope] or their salts for visualizing TRPA1 (transient receptor potential ankyrin 1) in vivo. For example, compound III (preparation given) was reacted with [11C]methyl triflate (11CH3OTf, preparation given) to provide compound IV. According to the present invention, it is possible to provide a technol. for visualizing TRPA1 in vivo. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Synthetic Route of 152626-77-2

The Article related to thiazole indazole derivative preparation trpa1 visualization bioimaging agent radioisotope, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Synthetic Route of 152626-77-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On June 2, 2016, Davie, Rebecca Louise; Edwards, Hannah Joy; Evans, David Michael; Hodgson, Simon Teanby published a patent.Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine The title of the patent was Preparation of N-((het)arylmethyl)heteroaryl-carboxamides compounds as plasma kallikrein inhibitors. And the patent contained the following:

The invention provides compounds of formula I, compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds Compounds of formula I wherein B is (un)substituted Ph, benzothiophenyl, benzofuranyl, benzomorpholinyl, etc.; W is C and X, Y, Z are independently C, N, O and S; R5 and R6 are independently H, alkyl, NH2, etc.; R7 is H; A is (un)substituted aryl and (un)substituted heteroaryl; are claimed. Example compound II was prepared by amidation of 3-(methoxymethyl)-1-(4-((2-oxopyridin-1(2H)-yl)methyl)benzyl)-1H-pyrazole-4-carboxylic acid with (3,5-dimethoxyphenyl)methanamine. The invention compounds were evaluated for their plasma kallikrein inhibitory activity (data given). The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine

The Article related to hetero arylmethyl heteroaryl carboxamide preparation plasma kallikrein inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine

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Ether – Wikipedia,
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On August 22, 1995, James, Donald R.; Baker, Don R.; Mielich, Steven D.; Michaely, William J.; Fitzjohn, Steven; Knudsen, Christopher G.; Mathews, Christopher; Gerdes, John M. published a patent.Application In Synthesis of 4-Bromo-5-methoxy-2-methylaniline The title of the patent was Aryl indazoles, a process for producing them, and their use as herbicides. And the patent contained the following:

This invention relates to substituted arylindazoles I (R1 = H or halo; R2 = e.g., N, nitro, halo; R3 = e.g., H, halo; R4, R5, R6 are independently, e.g., H, halo, nitro, hydroxy, cyano; R7 = H, halo, C1-6 alkyl, nitro; R8 = H, halo), a process for producing them and their use as herbicides. Thus, e.g., 5-methoxy-2-methyl-4-nitroaniline was converted to 6-methoxy-5-nitroindazole by standard diazotization-cyclization route; arylation of the latter with 3,5-dichloro-4-fluorobenzotrifluoride afforded the 1-arylindazole I (R1-R8, X given resp. as: H, Cl, CF3, H, NO2, OMe, H, H, C-Cl) which exhibited 100% control pre-emergence of green foxtail, watergrass, wild mustard, and velvetleaf, and 100% control post-emergence of green foxtail, wild mustard, and velvetleaf. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Application In Synthesis of 4-Bromo-5-methoxy-2-methylaniline

The Article related to arylindazole herbicide, indazole aryl herbicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application In Synthesis of 4-Bromo-5-methoxy-2-methylaniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 27, 2005, Xu, Liangheng; Li, Xiang; Yao, Hongbing; Li, Xiaoying; Gao, Yun published a patent.Quality Control of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene The title of the patent was Preparation and application of poly(p-phenylenevinylene) derivatives. And the patent contained the following:

Poly(p-phenylenevinylene) derivatives are prepared by polymerization of CN- or halogen-containing benzene derivatives at 1.0-2.0 MPa and -80 to +150° for 1.0-18 h. The product has high relative mol. weight, low dispersion degree, good thermal stability, solubility, photoluminescence, and electroluminescence efficiency. The product is useful for light-emitting component, diode, photoemissive element, light activated element and various elec. pole unit. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Quality Control of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

The Article related to polyphenylenevinylene derivative preparation application photoluminescence electroluminescence, Plastics Manufacture and Processing: Preparation Of Resins and other aspects.Quality Control of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xia, Jin; Xu, Zili; Lu, Yimin; Yang, Yingge published an article in 2008, the title of the article was Ultrasonic synthesis and structure characterization of poly(2-ethoxy-5-(2′-ethylhexyloxy)-p-phenylenevinylene).COA of Formula: C15H24O2 And the article contains the following content:

The preparation of poly(2-ethoxy-5-(2′-ethylhexyloxy)-phenylenevinylene) (MEH-PPV) was investigated with p-methoxyphenol as raw material. Gel-free soluble and high-mol.-weight (Mn) MEH-PPV was prepared by the method of ultrasonic synthesis. The molar weight of the polymer was 7.9 × 105. The structure of the polymer was identified by IR, 1H-NMR and Raman spectra. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).COA of Formula: C15H24O2

The Article related to polyphenylenevinylene derivative preparation characterization ultrasound methoxyphenol, Plastics Manufacture and Processing: Preparation Of Resins and other aspects.COA of Formula: C15H24O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem