On August 10, 2021, Doi, Hisashi; Watanabe, Yasuyoshi; Choi, Yilong; Kida, Tatsuya; Tateishi, Ukihide; Kano, Daisuke; Mori, Shigeyuki; Mori, Yasuo; Uesugi, Motonari published a patent.Synthetic Route of 152626-77-2 The title of the patent was Preparation of thiazole and indazole derivatives for visualizing TRPA1. And the patent contained the following:
The present invention provides thiazole and indazole derivatives I and II [R1 = a substituent having a radioisotope; R2 = a substituent having a radioisotope] or their salts for visualizing TRPA1 (transient receptor potential ankyrin 1) in vivo. For example, compound III (preparation given) was reacted with [11C]methyl triflate (11CH3OTf, preparation given) to provide compound IV. According to the present invention, it is possible to provide a technol. for visualizing TRPA1 in vivo. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Synthetic Route of 152626-77-2
The Article related to thiazole indazole derivative preparation trpa1 visualization bioimaging agent radioisotope, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Synthetic Route of 152626-77-2
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Ether | (C2H5)2O – PubChem