Tag: M.W=100-200

Application of 450-91-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 450-91-9, name is 4-Fluoro-2-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

iii: Intermediate 3 (1.0 eq) and cesium carbonate (2.0 eq) and corresponding phenylamine (1.2 eq) were added into a dry reaction flask. Dry DMF was used as reaction solvent, N2 was used to remove water vapor and oxygen. Then catalyst and ligand Pd(AcO)2 (0.1 eq) and Xantphos (0.1 eq) were added. The reaction mixture was transferred to a 60 C oil bath, 6~7 hours. After the reaction completed, the mixture was filtered and evaporated. Intermediate 4 was gained. The yield was 50%.

The synthetic route of 4-Fluoro-2-methoxyaniline has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(2-Methoxyphenoxy)ethylamine

(f) A mixture comprising 2-(2-methoxyphenoxy)ethylamine (10 g, 59.9 mmol), diisopropylethylamine (13.9 mL, 81.6 mmol) and dichloromethane (80 mL) was cooled to 0 C. and then a solution of 3-methoxy-4-nitrobenzoyl chloride (11.76 g, 54.4 mmol) in dichloromethane (50 mL) was added dropwise. The mixture was allowed to warm to 23 C. over two hours, quenched with aqueous hydrochloric acid (3M, 20 mL), washed with water (3*20 mL), dried (Na2SO4) and concentrated in vacuo to provide N-[2-(2-methoxyphenoxy)ethyl]-3-methoxy-4-nitrobenzamide (14 g, 74% yield) an off white solid; MS (PB-PCI) C17H18N2O6 m/e calc 346.34; found 347 (MH+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 446-61-7, name is 2-Fluoro-6-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-Fluoro-6-methoxyaniline

(1) 2-Fluoro-6-methoxyaniline (7.80 g) and 17.23 g of di-(2-bromoethyl)amine hydrobromide were dissolved in 5 ml of water and, by heating at about 110 C. on a bath, 10 ml of 30% potassium hydroxide solution was added thereto (each about 3.5 ml once an hour). Heating was further continued (7 hours in total). After cooled, the reaction solution was made alkaline with aqueous solution of sodium hydroxide to salt out and extracted with chloroform twice. The extract was washed with saturated sodium chloride solution, dried over sodium sulfate, the solvent was evaporated therefrom, and the residue was purified by a column chromatography to give 8.95 g of oily 1-(2-fluoro-6-methoxyphenyl)piperazine in 34.93 g yield or 94%.

According to the analysis of related databases, 446-61-7, the application of this compound in the production field has become more and more popular.

Related Products of 1579-40-4,Some common heterocyclic compound, 1579-40-4, name is Di-p-tolyl Ether, molecular formula is C14H14O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A neat mixture of p-tolyl ether (1.784 g, 9.00 mmol), 5-tertbutylisophthalic acid (1.000 g, 4.50 mmol), zinc chloride (4.478 g, 32.86 mmol) and phosphorus oxychloride (3.4 mL, 36 mmol) were heated at 100 C for 24 h under a N2 atmosphere. The mixture was cooled to room temperature to give viscous dark red-orange oil. The tacky reaction product was suspended in EtOAc (150 mL) and loosened with a spatula, before being transferred and quenched with water (250 mL) and rapidly stirred for 0.5 h. The resulting emulsion was extracted with EtOAc (3 100 mL) to give a bright orange solution. The combined organic layers were then washed with water (2 100 mL) to afford a transparent yellow solution, which was dried over Na2SO4, filtered and silica gel added. The solvent was removed by rotary evaporation and the orange silicaabsorbed crude product was purified using flash chromatography on silica gel, eluting with hexanes-EtOAc (9:1). The first colourless fraction was collected, the solvent removed under reduced pressure, yielding 1 as a white solid (1.683 g, 65%). A second slightly pink-tinged band yielded 2 as a pink tinged solid. If CH2Cl2 was used as the extracting solvent, no 2 was obtained and the yield of 1 increased to >85%. Data for 1. M.p. 199e202 C. 1 H NMR (400 MHz, (CD3)2CO): d 7.23 (d, J 1.6, 2H, phen-H), 7.21 (t, J 1.6, 1H, ArH), 7.16 (m, 4H,xan-H), 7.07 (ddd, J 8.3, 2.2, 0.5, 4H, xan-H), 7.00 (d, J 8.3, 4H, xan-H), 5.24 (s, 2H, CeOH), 2.20 (s, 12H, xan-Me), 1.13 (s, 9H, Ar-tBu). 13C{1 H} NMR (100.6 MHz, (CD3)2CO): d 150.50 (Cq), 149.64 (2 Cq), 149.01 (4Cq), 132.96 (4Cq), 130.11 (4ArCeH), 129.51 (4ArCeH), 129.26 (4Cq), 122.74 (1ArCeH), 121.81 (2ArCeH), 116.58 (4ArCeH), 70.99 (2 Cq), 35.36 (t-Bu) 31.75 (3t-Bu), 20.99 (4Ar-Me). IR (ATR): ~nmax=cm1 3746 (vw), 3667 (w), 3642 (w), 3511 (w), 2950 (w), 2916 (w), 2859 (w), 1606 (w), 1482 (s), 1436 (m), 1420 (m), 1359 (m), 1310 (m), 1284 (s), 1257 (s), 1213 (s), 1135 (s), 1110 (m), 1014 (s), 952 (m), 902 (w), 887 (m), 807 (s), 763 (m), 757 (m). ()-HR-ESI-MS: Found m/z 579.2779 (calc. [C41H38O4] : m/z 582.2770).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Di-p-tolyl Ether, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41406-00-2, name is 3-Isopropoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 41406-00-2

Example 75 Preparation of 2-fluoro-3-iodo-N-(3-isopropoxyphenyl)-4-methylbenzamideOxalyl chloride (2 M in DCM) (1832 mul, 3664 mumol) was added to a suspension of 2- fluoro-3-iodo-4-methylbenzoic acid (684 mg, 2443 mumol) in DCM (20 mL) at 0 0C. One drop of DMF (cat) was added. The mixture was stirred at RT for 3 h. Solvent was removed under vacuum. DCM (5 mL) was added to the residue and the mixture was added slowly to a mixture of 3-isopropoxybenzenamine (540 muL, 3664 mumol) and triethylamine (681 muL, 4885 mumol) in DCM (10 mL) at 0 0C. The mixture was stirred at RT overnight and then water (50 mL) was added. The mixture was extracted with DCM (3 x 50 mL). The combined organic layers were washed with brine (100 mL) and dried over sodium sulfate. The solvent was removed in vacuo and the residue was purified by preparative TLC eluting with 10% EtOAc / hexane to give the title compound (683 mg, 68%). MS (M+H)+ 414.

The synthetic route of 41406-00-2 has been constantly updated, and we look forward to future research findings.

Reference of 538-86-3, These common heterocyclic compound, 538-86-3, name is (Methoxymethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A sealed tube was charged with isochroman (or benzylic ether;1 mmol), DTBP (1.5 mmol), thiol (or thiophenol; 1.5 mmol). Thereaction mixture was stirred at 120 °C for 6 h. The reactionmixture was then cooled to obtain a brown liquid. The organicsolutions could be purified directly by column chromatographyon silica gel to give the pure product (hexane?EtOAc, 20:1).

The synthetic route of 538-86-3 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 91-16-7, name is 1,2-Dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 91-16-7, category: ethers-buliding-blocks

A solution of 1,2-dimethoxybenzene (10 g, 72.4 mmol) in dichloromethane(50 ml) was added dropwise to a suspension of anhydrous FeCl3 (35.22 g, 217.2 mmol) in dichloromethane (100 ml) and concentrated sulphuric acid (0.5 ml). After complete addition (15 min), the reaction mixture was further stirred for 3 h at room temperature. 200 ml of methanol were then slowly added under vigorous stirring. The obtained mixture was further stirred for additional 30 min. And the precipitate was filtered off, washed with methanol (5 × 100 ml) and dried under reduced pressure to give a purple solid. Yield: 80%, 1HNMR (CDCl3) delta/ppm: 4.10 (s, 18H, OCH3), 7.80 (s, 6H, ArH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 450-91-9, name is 4-Fluoro-2-methoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 450-91-9, Recommanded Product: 450-91-9

4-Fluoro-2-methoxyaniline (2.4 g, 17.00 mmol)Was added portionwise to concentrated H2SO4 (15 mL) cooled in an ice / water bath,The temperature was maintained below 15 & lt; 0 & gt; C during the addition.The mixture was stirred until all of the formed solids had dissolved.KNO3 (0.815 mL, 17.00 mmol) was added in portions,So as to keep the temperature below 10 C. The mixture was stirred overnight and then poured onto ice / water.The mixture was basified with concentrated NH4OH. The resulting solid was filtered off,Then dissolved in CH2Cl2, washed with water, dried (Na2SO4),Concentrated on silica gel. Using FCC for purification,Eluting with 50% by weight of heptane in CH2Cl2,The title compound was obtained as a yellow crystalline solid (2.450 g, 77%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-2-methoxyaniline, and friends who are interested can also refer to it.

Application of 16452-01-0, A common heterocyclic compound, 16452-01-0, name is 3-Methoxy-4-methylaniline, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a threaded ACE glass pressure tube with a sealed Teflon screw cap equipped with a magnetic stirring bar, a mixture of 11a (0.200 g, 1.65 mmol), 12a (0.185 g, 1.65 mmol), p-TsOH (0.028 g, 0.16 mmol), and MS 4A (0.20 g) in toluene (10 mL) was stirred and heated at 130 C for 4.5 h under microwave irradiation (100 W). The solvent was removed under vacuum and the residue purified by column chromatography (silica gel, hexane-EtOAc, 98:2) to give 7a (0.32 g, 91%) as a brownish oil; Rf = 0.75 (hexane-EtOAc, 7:3).

The synthetic route of 16452-01-0 has been constantly updated, and we look forward to future research findings.

Electric Literature of 578-57-4, These common heterocyclic compound, 578-57-4, name is 1-Bromo-2-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of brominated aromatic compounds (1 equiv),bis(pinacolate)diboron (1.5 equiv) and anhydrous ethanol (15 mL)were added10%palladium-carbon (0.01 equiv), followed by potassium acetate (3 equiv) under argon. The mixture was heated in a 60 C with stirring for the indicated time. Thereactor was cooled to room temperature, and the reaction mixture was filtered, and thefiltrate was concentrated under reduced pressure. The residue was extracted with dichloromethane (20 mL×3), and organic layer was washed with water (20 mL×2)and once with brine (25 mL), dried over magnesium sulfate and concentrated in vacuo.The product was purified by silica gel flash chromatography on silica gel usingpetroleum as eluent.

The synthetic route of 578-57-4 has been constantly updated, and we look forward to future research findings.