Adding a certain compound to certain chemical reactions, such as: 450-91-9, name is 4-Fluoro-2-methoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 450-91-9, Recommanded Product: 450-91-9
4-Fluoro-2-methoxyaniline (2.4 g, 17.00 mmol)Was added portionwise to concentrated H2SO4 (15 mL) cooled in an ice / water bath,The temperature was maintained below 15 & lt; 0 & gt; C during the addition.The mixture was stirred until all of the formed solids had dissolved.KNO3 (0.815 mL, 17.00 mmol) was added in portions,So as to keep the temperature below 10 C. The mixture was stirred overnight and then poured onto ice / water.The mixture was basified with concentrated NH4OH. The resulting solid was filtered off,Then dissolved in CH2Cl2, washed with water, dried (Na2SO4),Concentrated on silica gel. Using FCC for purification,Eluting with 50% by weight of heptane in CH2Cl2,The title compound was obtained as a yellow crystalline solid (2.450 g, 77%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-2-methoxyaniline, and friends who are interested can also refer to it.