Tag: M.W=200-300

Related Products of 1516-96-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1516-96-7, name is 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

Under nitrogen protection, to a 250 mL dry 3-necked round bottom flask equipped with a magnetic stirrer and thermometer was added:THE was added dropwise to the solution of the residue prepared above under nitrogen at 0C. After stirring another 1.5h at room temperature, the mixture was quenched withwater at 0C and extracted three times withdichloromethane. The combined organic layers were dried over Na2504 and concentrated in vacuo. The residue was purified by flash chromatography on silica gel, eluting with petroleum ether/ethyl acetate = 75:25, to give product as a white solid (1.94 g, 81% yield).1.0 g tetraethyl (((2R)-propane-1,2-diylbis(oxy))bis(3,1-phenylene))bis(phosphonate) (2.0 mmol, 1.0 equiv.) in3.0 mL thionyl chloride (40.0 mmol, 20.0 equiv.) under nitrogen was added30.0 iL dimethylformamide (0.4 mmol, 0.2 equiv). The mixture was stirred under reflux for 18 h, during which time15.0 iL dimethylformamide (all together 8.0 mmol, 0.3 equiv.) was added after 12h. After the solvent was evaporated, the residue was dissolve in5.0 mL THE and concentrated in vacuo (once). The residue was used for the next step without further purification.To a phenyl magnesium bromide solution prepared from a suspension of0.53g magnesium turning (22.0 mmol, 11.0 equiv.) and6.0 g 5-bromo-1,3-di-tert-butyl-2-methoxybenzene (20.0 mmol, 10.0 equiv.) in20.0 mL10.0 mL50 mL

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; DSM IP ASSETS B.V.; BONRATH, Werner; FENG, Zheng-Chuan; MEDLOCK, Jonathan, Alan; PENG, Kun; ZHU, Zhibin; (28 pag.)WO2018/189107; (2018); A1;,
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Reference of 62415-74-1,Some common heterocyclic compound, 62415-74-1, name is 1,2-Dibromo-4-methoxybenzene, molecular formula is C7H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of Intermediate I-1 (0258) 5.31 g (20.0 mmol) of 1,2-dibromo-4-methoxybenzene, 3.30 g (30.0 mmol) of pyrocatechol, 0.190 g (1.0 mmol) of CuI, 0.264 g (1.0 mmol) of 18-crown-6, and 8.28 g (60.0 mmol) of K2CO3 were dissolved in 150 mL of dimethylformamide (DMF), and stirred at a temperature of about 140 C. for about 24 hours. The solution was cooled to room temperature, 60 mL of water was added thereto, and an organic layer was extracted three times therefrom using 60 mL of diethyl ether. The obtained organic layer was dried using magnesium sulfate (MgSO4), and the MgSO4 was removed by filtration. A solvent was next removed therefrom by evaporation. The obtained residue was separated and purified through silica gel chromatography to produce 3.21 g of Intermediate I-1 (yield: 75%). The obtained compound was identified by liquid chromatography-mass spectrometry (LC-MS). C13H10O3: M+1 215.1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dibromo-4-methoxybenzene, its application will become more common.

Reference:
Patent; SAMSUNG DISPLAY CO., LTD.; Kim, Youngkook; Jung, Hyejin; Han, Sanghyun; Hwang, Seokhwan; (115 pag.)US2017/77419; (2017); A1;,
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Adding a certain compound to certain chemical reactions, such as: 202865-59-6, name is 2-Bromo-4,6-difluoroanisole, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 202865-59-6, Application In Synthesis of 2-Bromo-4,6-difluoroanisole

[00190] Intermediate 18A. l-(3,5-Difluoro-2-methoxyphenyl)-2- (diphenylmethylene)hydrazine: To a mixture of palladium (II) acetate (0.040 g, 0.18 mmol) and xantphos (0.104 g, 0.179 mmol) in toluene (1 mL), l-bromo-3,5-difluoro-2- methoxybenzene (4.0 g, 18 mmol), (diphenylmethylene)hydrazine (3.52 g, 17.9 mmol) and sodium tert-butoxide (2.41 g, 25.1 mmol) were added followed by the addition of toluene (4 mL). The mixture was degassed twice and stirred for 6 h at 100 C under argon. After cooling to room temperature, EtO Ac and water were added. The organic layer was separated. The aqueous layer was extracted one more time with EtOAc. The combined organics were washed with water and brine, dried over MgSC^, filtered, and concentrated. The crude was purified by flash chromatography, eluting with EtOAc/hexanes to give Intermediate 18A (6.0 g, 84% yield). LCMS (ESI) m/z 339.4 (M+H)+, RT = 2.33 min (Method D). NMR (400 MHz, CDC13) delta ppm 3.63 (br. s, 3 H), 6.14 – 6.38 (m, 1 H), 7.08 – 7.20 (m, 5 H), 7.45 – 7.68 (m, 5 H), 7.97 (s, 1 H). 19F NMR (376.5 MHz, acetone-d6) delta ppm -115.46, -129.88.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4,6-difluoroanisole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; L’HEUREUX, Alexandre; HIEBERT, Sheldon; HU, Carol; LAM, Patrick Y.S.; LLOYD, John; PI, Zulan; QIAO, Jennifer X.; THIBEAULT, Carl; TORA, George O.; YANG, Wu; WANG, Yufeng; WANG, Tammy C.; BOWSHER, Michael S.; RUEL, Rejean; WO2014/22343; (2014); A1;,
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Electric Literature of 1462-37-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1462-37-9, name is ((2-Bromoethoxy)methyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1.67 g (5 mmol) 4-[({[(1R, 2S, 4R)-1, 7, 7-TRIMETHYLBICYCLO [2.2. 1] hept-2-yl] amino} carbonyl)- AMINO]-LH-PYRROL-2-CARBONSUREETHYLESTER (Beispiel 1) werden IN 10 ml absolutem DMF gelst und mit 1.07 g (9.5 mmol) Kalium-tert-butylat versetzt. Nach 5 min Rhren bei RT werden 1.91 g (9.5 mmol) 1-BROMETHYL-2-PHENYLETHER zugegeben. Die Reaktionsmischung wird ber Nacht bei RT gerhrt, dann werden noch einmal 600 mg (3 mmol) 1-BROMETHYL-2-PHENYLETHER und 336 mg (3mmol) KALIUM-TERT-BUTYLAT zugegeben. Die Reaktionsmischung wird ber Nacht bei RT gerhrt, dann werden langsam 3.5 ml Wasser und 0.5 ml Methanol zugetropft. Die entstehenden Kristalle werden abgesaugt und mit Wasser/Methanol (1 : 1-Gemisch) und wenig Methanol gewaschen. Ausbeute : 1. 87 g (83 percent d. Th.) MS (ESI+) : m/z = 454 (M+H) + 1H-NMR (300MHZ, DMSO-d6) : deltaelta; = 7.9 (s, 1H), 7.25 (TR, 2H), 7.2 (d, lH), 6.85-6. 95 (m, 3H), 6.65 (d, 1H), 6.0 (d, 1H), 4.6 (TR, 2H), 4.15-4. 25 (m, 4H), 3.95 (m, 1H), 2.2 (M, 1H), 1.55-1. 8 (m, 3H), 1.35-1. 1 (m, 2H), 1.25 (tr, 3H), 0.9 (s, 3H), 0.85 (s, 3H), 0.8 (D, 1H), 0.75 (s, 3H) ppm.

The synthetic route of ((2-Bromoethoxy)methyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER HEALTHCARE AG; WO2004/52852; (2004); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3401-47-6, name is 1-Bromo-2-methoxynaphthalene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1-Bromo-2-methoxynaphthalene

1-Bromo-2-methoxynaphthalene (20.0 g, 84.4 mmol),Phenylboronic acid (11.3 g, 92.8 mmol),Palladium acetate (0.10 g, 0.46 mmol),Triphenylphosphine (0.85 g, 2.78 mmol)And potassium phosphate (40.9 g, 177.9 mmol) were placed in a flask,Add 60 ml of water and 120 ml of dimethoxyethane mixed solution and reflux for 6 hours. After cooling at room temperature,Ammonium chloride aqueous solution (150 mL)And 200 mL of diethyl ether were injected,The organic layer was separated and the residue was extracted with diethyl ether,After drying the collected organic layer with magnesium sulfate,After removal of volatiles,The residue was purified with hexane using a silica gel chromatography tube,13.0 g (yield: 66%) of 2-methoxy-1-phenylnaphthalene as a colorless liquid was obtained.

The synthetic route of 3401-47-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SK INNOVATION COMPANY LIMITED; OK, MYUNGAHN; SHIN, DONGCHEOL; JEONG, JISU; HAHN, JONGSOK; LEE, HOSEONG; SHIN, DAEHO; (23 pag.)JP5656843; (2015); B2;,
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Some common heterocyclic compound, 32338-02-6, name is 2-Bromo-4-methoxyaniline, molecular formula is C7H8BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 32338-02-6

Under inert gas protection, 100 ml of a mixed organic solvent of acetic acid and acetonitrile with a volume ratio of 2: 1 was added to the reactorAgent, 10mmol successively added thereto the above formula (I-1) compound of the formula 12mmol (II-1) compounds, 1 mmol of copper trifluoromethanesulfonate catalyst, 1 mmol of cocatalyst, 20mmol bis (trifluoroacetate) iodobenzene, and To the reaction solution was added 15 mmol of isoamyl nitrite. The temperature was raised to 50 ¡ã C with stirring, and the reaction was stirred at this temperature for 8 hours. After the reaction was completed, all volatiles were removed in vacuo and the product extracted with ethyl acetate, the organic solvent phase was removed and the resulting residue was separated by column chromatography on 300-400 mesh silica gel, elution solvent is a volume ratio of 4: 1 petroleum ether and acetic acid Ethyl ester, the compound of the above formula (III-1) was obtained in a yield of 93.5percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 32338-02-6, its application will become more common.

Reference:
Patent; Zhou Xiaofang; (6 pag.)CN107056703; (2017); A;,
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Synthetic Route of 37895-73-1,Some common heterocyclic compound, 37895-73-1, name is 1,2-Dibromo-4,5-dimethoxybenzene, molecular formula is C8H8Br2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 6.00 g (22.8 mmol) of 1,2-dibromo-4,5-dimethylbenzene in 12 mL of tetrahydrofuran wasadded to preliminary prepared 30 mL of a 1M solutionof iso-PrMgLiCl in tetrahydrofuran and stirred at -17to -13C. After 3 h, 5.12 g (23.25 mmol) of chlorodiphenylphosphinewas added dropwise to the solutionat -20 to -10C. The obtained solution was stirred for30 min at -10C, and then it was allowed to warm upto room temperature, stirred for additional 16 h, andevaporated. 30 mL of methylene chloride and 20 mLof a saturated aqueous solution of ammonium chloridewere added to the residue. The organic phase wasseparated and dried over anhydrous sodium sulfate.The residue after the evaporation was recrystallizedusing an ethanol-acetone mixture.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dibromo-4,5-dimethoxybenzene, its application will become more common.

Reference:
Article; Cheredilin; Sheloumov; Senin; Kozlova; Afanas?ev; Bespalova; Petroleum Chemistry; vol. 59; (2019); p. S72 – S87; Neftekhimiya;,
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Adding a certain compound to certain chemical reactions, such as: 446-59-3, name is 2-Bromo-1-fluoro-3-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 446-59-3, Computed Properties of C7H6BrFO

To a solution of the above compound (58mg, 0. 224MMOL) in CH, CI (LML) cooled over dry ice/acetone bath was added boron TRIBROMIDE (224UL, 0. 224MMOL) and stirred over night at room temperature. After this time, the mixture was treated with methanol (3X5ML) and concentrated in vacuo to give 2-(1,1-dioxido-1, 2-thiazinan-2-yl) -3-fluorophenol. Low resolution mass spectrometry: (M+H+)= 246.16. 1H NMR (400MHZ, CDC13) 8 7.19 (dd, 1H, J=8.4 and 15HZ), 6.81 (d, 1H, J=8.4Hz), 6.70 (t, 1H, lOHz), 3.82-3. 90 (M, 1H), 3.60-3. 68 (m, 1H), 3.34-3. 43 (M, 1H), 3.26-3. 34 (M, 1H), 2.34-2. 43 (m, 2H), 1.94-2. 08 (M, 1H) and 1.77-1. 89 (M, 1H) ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-fluoro-3-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK & CO., INC.; WO2005/16886; (2005); A1;,
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Adding a certain compound to certain chemical reactions, such as: 106854-77-7, name is 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106854-77-7, Computed Properties of C8H6BrF3O

EXAMPLE 7 4-(2,2,2-Trifluoroethoxy)phenylhydrazine hydrochloride A solution of 4-bromophenyl 2,2,2-trifluoroethyl ether (5.2 g, 20 mmol) in THF (75 ml) was cooled to -75 C. under nitrogen. A solution of 2.7M n-butyllithium (7.5 ml, 20 mmol) was added dropwise. After 15 minutes, a solution of di-t-butylazodicarboxylate (4.5 g, 19 mmol) in THF (30 ml) was added quickly with stirring. The solution was allowed to warm to -40 C., resulting in the formation of a precipitate. Acetic acid (1.5 ml), water (10 ml), saturated sodium chloride (10 ml) and hexane (100 ml) were then added to the mixture. The organic solution was dried over MgSO4, filtered and evaporated. The residue was dissolved in 1:1 carbon tetrachloride-hexane and left to crystallize overnight. The resulting crystalline precipitate was collected, providing 4.25 g of white powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ortho Pharmaceutical Corporation; US4864032; (1989); A;,
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Application of 332-48-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 332-48-9, name is 1-(2-Bromoethoxy)-4-fluorobenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 116 1-(2-(4-Fluorophenoxy)ethyl)-4-(4-methylbenzyl)piperidine hydrochloride STR152 From a mixture of 4-(4-methylbenzyl)piperidine (500 mg, 2.21 mmol), 2-(4-fluorophenoxy)ethyl bromide (508 mg, 2.32 mmol) and K2 CO3 (626 mg, 4.53 mmol) in CH3 CN (20 mL) was obtained the title compound as colorless plates (293 mg, 63%), mp 189-191 C., 1 H NMR (CDCl3) 1.60-2.12 (m, 5H), 2.31 (s, 3H), 2.57 (d, J=7.2 Hz, 2H), 2.62-2.82 (m, 2H), 3.20-3.55 (m, 2H), 3.65 (d, J=12 Hz, 2H), 4.51 (t, J=4.5 Hz, 2H), 6.78-6.84 (m, 2H), 6.92-7.02 (m, 6H), 7.08 (d, J=8.1 Hz, 2H), 12.56 (bs, 1H); Anal. Calcd for C21 H27 ClFNO: C, 69.31; H, 7.48; N, 3.85. Found: C, 69.49; H, 7.39; N, 3.88.

The synthetic route of 1-(2-Bromoethoxy)-4-fluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Warner-Lambert Company; Cocensys, Incorporated; US6124323; (2000); A;,
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