Some common heterocyclic compound, 32338-02-6, name is 2-Bromo-4-methoxyaniline, molecular formula is C7H8BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 32338-02-6
Under inert gas protection, 100 ml of a mixed organic solvent of acetic acid and acetonitrile with a volume ratio of 2: 1 was added to the reactorAgent, 10mmol successively added thereto the above formula (I-1) compound of the formula 12mmol (II-1) compounds, 1 mmol of copper trifluoromethanesulfonate catalyst, 1 mmol of cocatalyst, 20mmol bis (trifluoroacetate) iodobenzene, and To the reaction solution was added 15 mmol of isoamyl nitrite. The temperature was raised to 50 ¡ã C with stirring, and the reaction was stirred at this temperature for 8 hours. After the reaction was completed, all volatiles were removed in vacuo and the product extracted with ethyl acetate, the organic solvent phase was removed and the resulting residue was separated by column chromatography on 300-400 mesh silica gel, elution solvent is a volume ratio of 4: 1 petroleum ether and acetic acid Ethyl ester, the compound of the above formula (III-1) was obtained in a yield of 93.5percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 32338-02-6, its application will become more common.
Reference:
Patent; Zhou Xiaofang; (6 pag.)CN107056703; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem