Adding a certain compound to certain chemical reactions, such as: 446-59-3, name is 2-Bromo-1-fluoro-3-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 446-59-3, Computed Properties of C7H6BrFO
To a solution of the above compound (58mg, 0. 224MMOL) in CH, CI (LML) cooled over dry ice/acetone bath was added boron TRIBROMIDE (224UL, 0. 224MMOL) and stirred over night at room temperature. After this time, the mixture was treated with methanol (3X5ML) and concentrated in vacuo to give 2-(1,1-dioxido-1, 2-thiazinan-2-yl) -3-fluorophenol. Low resolution mass spectrometry: (M+H+)= 246.16. 1H NMR (400MHZ, CDC13) 8 7.19 (dd, 1H, J=8.4 and 15HZ), 6.81 (d, 1H, J=8.4Hz), 6.70 (t, 1H, lOHz), 3.82-3. 90 (M, 1H), 3.60-3. 68 (m, 1H), 3.34-3. 43 (M, 1H), 3.26-3. 34 (M, 1H), 2.34-2. 43 (m, 2H), 1.94-2. 08 (M, 1H) and 1.77-1. 89 (M, 1H) ppm.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-fluoro-3-methoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK & CO., INC.; WO2005/16886; (2005); A1;,
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