Tag: M.W=200-300

Related Products of 10484-56-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10484-56-7 name is 2-Butoxynaphthalene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A flame dried Schlenk flask was charged with Bi(OTf)3 (13.1 mg,0.020 mmol), alkyl aryl ethers (0.40 mmol), alcohols or thiols (1.2 mmol) andCH2ClCH2Cl (0.20 mL), and then the resulting mixture was stirred at 110 C (or 130 C forthe synthesis of 1m) for 24 h. The solvent was removed under the reduced pressure, andthe residue was subjected to flash column chromatography on silica gel with hexane /AcOEt as eluents to afford the corresponding aryl ethers or aryl thioethers

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Butoxynaphthalene, and friends who are interested can also refer to it.

Application of 866633-25-2, These common heterocyclic compound, 866633-25-2, name is 2-Bromo-4-fluoro-1-(trifluoromethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of the aryl bromide (from Step 2 above) (5g) in THF (25 mL) was added Isopropylmagnesium chloride (15 mL, 2.0M in THF) at room temperature. After stirring at the ambient for 2 h, B (OiPr)3 added to the reaction and stirred overnight. The reaction was quenched with IN HCl, stirred at room temperature for 30min and extracted with EtOAc. The residue obtained after removal of the solvent in vacuo, was dissolved in 10% KOH, extracted with ether. The aqueous phase was acidified with concentrated HCl and extracted with EtOAc. The organic layer was dried over Na2SO4 and concentrated to give the aryl boronic acid as a white solid. ¹H NMR (CDCl3) : 7.28-7.32 (m, 1H), 7.17-7.22 (m, 2H) MS (ESI): m/e 225 (M+1)+

Statistics shows that 2-Bromo-4-fluoro-1-(trifluoromethoxy)benzene is playing an increasingly important role. we look forward to future research findings about 866633-25-2.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 332-48-9, name is 1-(2-Bromoethoxy)-4-fluorobenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H8BrFO

C) 1-(2-(4-Fluorophenoxy)ethyl)-4-(4-nitrobenzyl)piperidine hydrobromide. This compound was prepared in a manner similar to example 25. From 4-(4-nitrobenzyl)piperidine hydrochloride (427 mg, 1.66 mmol) and 2-(4-fluorophenoxy)ethyl bromide (381 mg, 1.74 mmol) there was obtained the hydrobromide salt as a pale beige powder (510 mg, 94%): mp 147-148 C.; 1 H NMR (CDCl3) 1.65-1.89. (m, 3 H), 2.20 (q, J=12 Hz, 2 H), 2.69-2.90 (m, 4 H), 3.35-3.45 (m, 2 H), 3.73 (d, J=12 Hz, 2 H), 4.55 (t, J=3.6 Hz, 2 H), 6.77-7.04 (m, 4 H), 7.30 (d, J=8.4 Hz, 2 H), 8.16 (d, J=8.4 Hz, 2 H), 11.75 (bs, 1 H). Anal. Calcd for C20 H24 BrFN2 O3: C, 54.68; H, 5.51; N, 6.38. Found: C, 54.67; H, 5.36; N, 6.29.

The synthetic route of 332-48-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 3401-47-6, These common heterocyclic compound, 3401-47-6, name is 1-Bromo-2-methoxynaphthalene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The mixture of anisole(1c, 0.216 mg, 2 mmol) and acetyl chloride (2a, 0.157 mg, 2 mmol) was treated with CTAB/CTAC, (0.001 mol), in dichloroethane and the resulting reaction mixture was heated in a controlled microwave synthesizer (BiotageInitiator+SP Wave model (0.200W at 2.45 GHz, capped at 60W duringsteady state) for 5 min (attains temperature 100 C and 2 bar pressure). The final product (3o) was isolated by absorbing the reaction mixture into silica geland purifying it by column chromatography using ethyl acetate-petroleumether as the eluent.

Statistics shows that 1-Bromo-2-methoxynaphthalene is playing an increasingly important role. we look forward to future research findings about 3401-47-6.

Related Products of 24988-36-1, The chemical industry reduces the impact on the environment during synthesis 24988-36-1, name is 1,5-Dibromo-2,4-dimethoxybenzene, I believe this compound will play a more active role in future production and life.

25 parts of the compound represented by the formula (1-52) is converted into tetrahydrofuran.(Kanto Chemical Co., Ltd.)It was dissolved in 111 parts, cooled to -78 C., and while stirring, 234.2 parts of a 2.5 M hexane solution of n-butyllithium (manufactured by Aldrich Co.) was added dropwise.After input,Stir for 45 minutes at -78 C,With cooling to -78 C., 156 parts of iodomethane (manufactured by Tokyo Chemical Industry Co., Ltd.) was added dropwise.After input,It heated up to 23 degreeC and stirred for 5 hours.After the reaction,The reaction mixture was gradually added to 500 parts of ice water.After that, extract with water-toluene solvent,After concentration, 21 parts of crude product was obtained.This crude product is separated and purified by silica gel column chromatography,17 parts of the compound represented by the formula (1-53) were obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Dibromo-2,4-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

Related Products of 59557-91-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59557-91-4 name is 4-Bromo-2-methoxyaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 62 5-(2,3-dichlorobenzyl)-7-{ [2-methoxy-4-(piperidin-4-yl)phenyl]amino} [l ,2,4]triazolo[4,3- c]pyrimidine-8-carboxamide Example 62A feri-butyl 4-(4-amino-3-methoxyphenyl)-5,6-dihydropyridine-l(2//)-carboxylate A mixture of 4-bromo-2-methoxybenzenamine (1.21 g, 6.0 mmol), tert-butyl 4- (3,3,4,4-tetramethylborolan-l -yl)-5,6-dihydropyridine-l (2//)-carboxylate (1.95 g, 6.3 mmol), sodium carbonate (1 .91 g, 18 mmol) and 1 , 1 ‘- bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.22 g, 0.3 mmol) in dioxane (25 mL) and water (5 mL) was degassed with nitrogen and heated to 90C for 15 hours. After cooling to ambient temperature, the mixutre was filtered, concentrated and purified by flash chromatography eluting with 200: 1 dichloromethane:methanol to give the title compound. MS: 305 (M+Hf).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-methoxyaniline, and friends who are interested can also refer to it.

Related Products of 1663-61-2, The chemical industry reduces the impact on the environment during synthesis 1663-61-2, name is (Triethoxymethyl)benzene, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of arylsulfonyl hydrazine (10 mmol),ortho ester (12 mmol), and acetic acid (1 mmol) was stirred at 80-90 °C for 12h. The reaction mixture was diluted with MeOH (50 mL). The precipitate wascollected by filtration and purified by column chromatography on silica gel(50percent EtOAc:50percent hexane).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Triethoxymethyl)benzene, other downstream synthetic routes, hurry up and to see.

Related Products of 170015-99-3,Some common heterocyclic compound, 170015-99-3, name is 2-(4-(Trifluoromethoxy)phenyl)ethanamine, molecular formula is C9H10F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

S.3. (5-Chloro-thieno[2,3-d]pyrimidin-4-yl)-[2-(4-trifluoromethoxy-phenyl)-ethyl]-amine (Compound example C.5); 0.5 g (2.4 mmol) 4,5-dichloro-thieno-[2,3-d]-yprimidine are solved in 20 ml toluol. Subsequently 0.271 g (2.7 mmol) triethylamin, a catalytic amount of tetrabutyl- ammoniumiodide and 0.55 g (2.7 mmol) 2-(4-trifluoromethoxyphenyl)-ethylamin are added. The solution is heated under reflux for 6 hours, and stirred further 12 hours at room temperature. The solvent is destillated, the residue is reverted in CH2CI2 and is washed with 2N HCI and H2O. The residue is stirred and sucked off with hexane after being dryed and concentrated. The yield of compound C.5 obtained is 0.73 g (1.9 mmol, 76% of theoretical yield) and has a melting point Tmp of 77-79C. 1H-NMR (CDCI3): 8.50 (s, 1 H), 7.25 (d, 2H), 7.15 (d, 2H), 7.05 (s, 1 H), 6.55 (bs,1 H), 3.90 (t, 2H), 3.00 (t, 2H);

The synthetic route of 170015-99-3 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 873980-68-8, name is 4-Bromo-2-methoxy-5-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., category: ethers-buliding-blocks

EXAMPLE 72B N,N-dibenzyl-4-bromo-2-methoxy-5-methylbenzenamineA suspension of EXAMPLE 72A (3 g, 14 mmol), (bromo methyl)benzene (6 g, 35 mmol) and potassium carbonate (4.8 g, 35 mmol) in acetonitrile (150 mL) was heated at reflux for 20 hours. After concentration, the residue was diluted with ethyl acetate (100 mL) and washed with water (30 mL). The organic layer was dried over anhydrous sodium sulfate. filtered, concentrated and purified by flash chromatography on silica gel (200-300 mesh) eluting with 50/1 petroleum ether/ethyl acetate to give the title compound. MS: 396 (M+H+).

According to the analysis of related databases, 873980-68-8, the application of this compound in the production field has become more and more popular.

Some common heterocyclic compound, 35896-58-3, name is 1,2,3,4-Tetramethoxy-5-methylbenzene, molecular formula is C11H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 35896-58-3

To a stirred solution of 5a (4.24 g, 20 mmol) in CH2Cl2 (30 mL) was added dichloromethyl methyl ether (6.89 g, 60 mmol) at 0 C followed by addition of TiCl4 (11.38 g, 60 mmol)41 S. Ohkawa, S. Terao, Z. Terashit, Y. Shibouta and K. Nishikawa, J. Med. Chem. 34 (1991), p. 267. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (36)41 (see Scheme 4). The resulting mixture was stirred for 4 h at ambient temperature and then poured into ice water. After stirring vigorously for 10 min, the organic layer was separated. It was washed with water, dried, and evaporated. The residue was chromatographed on silica gel to give 5b (90%) as a light yellow liquid. 1H NMR (500.0 MHz, CDCl3, 298 K): 3.99 (s, 12H, 4× -OCH3), 2.25 (s, 3H, -CH3), 10.45 (s, H, -CHO) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 35896-58-3, its application will become more common.