Related Products of 170015-99-3,Some common heterocyclic compound, 170015-99-3, name is 2-(4-(Trifluoromethoxy)phenyl)ethanamine, molecular formula is C9H10F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
S.3. (5-Chloro-thieno[2,3-d]pyrimidin-4-yl)-[2-(4-trifluoromethoxy-phenyl)-ethyl]-amine (Compound example C.5); 0.5 g (2.4 mmol) 4,5-dichloro-thieno-[2,3-d]-yprimidine are solved in 20 ml toluol. Subsequently 0.271 g (2.7 mmol) triethylamin, a catalytic amount of tetrabutyl- ammoniumiodide and 0.55 g (2.7 mmol) 2-(4-trifluoromethoxyphenyl)-ethylamin are added. The solution is heated under reflux for 6 hours, and stirred further 12 hours at room temperature. The solvent is destillated, the residue is reverted in CH2CI2 and is washed with 2N HCI and H2O. The residue is stirred and sucked off with hexane after being dryed and concentrated. The yield of compound C.5 obtained is 0.73 g (1.9 mmol, 76% of theoretical yield) and has a melting point Tmp of 77-79C. 1H-NMR (CDCI3): 8.50 (s, 1 H), 7.25 (d, 2H), 7.15 (d, 2H), 7.05 (s, 1 H), 6.55 (bs,1 H), 3.90 (t, 2H), 3.00 (t, 2H);
The synthetic route of 170015-99-3 has been constantly updated, and we look forward to future research findings.