These common heterocyclic compound, 6876-00-2, name is 1-Bromo-3-phenoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C12H9BrO
Under an argon atmosphere, butyl lithium (1.56 M, hexane solution: 16 ml) was added at -78C to an anhydrous THF solution (40 ml) of the compound of Reference Example 15 (6.0 g) and stirred at this temperature for 30 minutes. Boric acid triisopropyl ester (4.7 g) was added. The mixture was stirred at -78C for 30 minutes, and after raising the temperature to 25C, the mixture was further stirred for 30 minutes. To the reaction solution, was then added 1 M hydrochloric acid (30 ml), and after 30 minutes of stirring at 25C, the organic layer was separated and washed with saturated brine. The solvent was then evaporated under reduced pressure, thereby giving 4.6 g of the desired product.
The synthetic route of 1-Bromo-3-phenoxybenzene has been constantly updated, and we look forward to future research findings.