Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 74137-36-3, name is 1,3-Dibromo-5-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74137-36-3, Product Details of 74137-36-3

The Bl (3.34g, 10 mmol) was added vial, the injection of THF dried, placed in a dry ice – acetone bath cooling, -78 ° C was added dropwise n-BuLi (1 lmmol, 2.5M) solution, stirring was continued for 3 hours and then triisopropyl borate (2.07g, 11 mmol) added to the bottle, slowly brought to room temperature and stirred overnight. After completion of the reaction, dilute HC1 solution was dropwise jerk, and extracted with methylene chloride, the organic layer was dried, solvent was removed, dichloromethane and petroleum ether (60-90) was washed with a mixture of beating to give D-1 (2.57g, y = 86percent),

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Synthetic Route of 38197-43-2, A common heterocyclic compound, 38197-43-2, name is 2-Bromo-1-methoxy-3-methylbenzene, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A: 2-methoxy-6-methylbenzonitrile: To a flask containing a stir bar was added 2-bromo-l- methoxy-3-methylbenzene (7.5 g, 37 mmol), CuCN (6.7 g, 75 mmol) followed by addition of DMF (60 mL); the resulting mixture was then refluxed at 150 C overnight. When the reaction was complete, as evidenced by LC analysis, the reaction flask was taken out of the oil bath and cooled to room temperature. To the reaction mixture was then poured DCM (20 mL) and a precipitate formed immediately. The solids were filtered, re-dissolved in DCM, absorbed into silica gel and and loaded into column with Hexanes:EtOAc (1 : 1) to afford the title product.

The synthetic route of 38197-43-2 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59557-91-4, name is 4-Bromo-2-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 4-Bromo-2-methoxyaniline

At room temperature, concentrated sulfuric acid (185 mL) and deionized water (144 mL) were added with mechanical stirring in a three-necked flask.Glycerol (768.5 mmol, 207.5 g) was added and the temperature was lowered to room temperature. Sodium 3-nitrobenzenesulfonate (733 mmol, 165 g) was added in portions and the reaction was carried out at 80 C for 3 hours, 4-bromo-2-methoxyaniline (compound shown by the formula (I-1)) (495 mmol, 100.0 g) was added portionwise with vigorous stirring to giveHeat to 120 C and react overnight. Add water (600 mL) and adjust pH to approx. 7.0 with concentrated aqueous ammonia. Extract with water and ethyl acetateAfter the extraction, the organic phase was dried over anhydrous sodium sulfate, filtered, and the solvent was spinned to give 103 g of tan by column chromatographyThe oily product (compound represented by the formula (I)) had a yield of 87.4% and a purity of 94%.

The synthetic route of 59557-91-4 has been constantly updated, and we look forward to future research findings.

2132-62-9, name is 1,2-Bis(4-methoxyphenyl)ethyne, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C16H14O2

take 1,2-dicarbonylmethyl ester-Indolizine 46.6mg (corresponding to 0.20 mmol), 71.5 mg (equivalent to 0.30 mmol) of 1,2-bis(4-methoxyphenyl) acetylene, 4.5 mg of palladium acetate (equivalent to 0.02 mmol), Potassium acetate was 5.0 mg (equivalent to 0.01 mmol), 1.5 ml of dimethylsulfoxide and then stirred under heating at 130 C for 1 hours under 1 atmosphere of oxygen and separated to obtain the sixth number target Product 78.9 mg (yield 84%).

The synthetic route of 2132-62-9 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 116557-46-1, name is 3-Bromo-2-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-Bromo-2-methoxyaniline

[00238j To a reaction vial charged with 3-bromo-2-methoxyaniline (1.12 g, 5.54mmol), 1 -methyl-4-(4,4,5 ,5 -tetramethyl- 1,3 ,2-dioxaborolan-2-yl)- 1 H-pyrazole (1.499 g,7.21 mmol) in dioxane (6 mL) was added aqueous potassium phosphate (2.0 M) (5.54 ml,11.09 mmol). The resulting mixture was deoxygenated by bubbling argon through themixture for 5 minutes. [1,1 ?-Bis(diphenylphosphino)ferrocene] dichloropalladium(II)(PdC12(dppf), 0.122 g, 0.166 mmol) was then added and the mixture was heated at 110 Cfor 2 hours. The reaction was cooled, diluted with ethyl acetate (200 mL), washed with water, brine, dried over anhydrous sodium sulfate, filtered and concentrated to afford tan oil as the crude product mixture. This material was purified by silica gel flash chromatography using hexanes/ethyl acetate mixtures as the eluent. Fractions containingthe desired product were collected, combined, and concentrated under vacuum to afford0.87 g (77%) of the desired product as an oil which solidified upon standing. HPLC (Method N) = 0.89 minutes. LCMS MH+ 204.1.

According to the analysis of related databases, 116557-46-1, the application of this compound in the production field has become more and more popular.

Reference of 36805-97-7,Some common heterocyclic compound, 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, molecular formula is C11H25NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,6-Dichloro-isonicotinic acid (11.2 g, 57.1 mmol) is suspended in toluene (150 mL) at 800C and then treated with N,N-dimethylformamide di-tert.-butyl acetal (50 mL, 209 mmol).The dark mixture is stirred at 800C for 12 h, then at rt for 16 h. The dark solution is diluted with diethyl ether (400 mL), washed with sat. aq. NaHCO3 solution (3×100 mL), dried overNa2SO4, filtered and concentrated. The crude product is purified by MPLC on silica gel eluting with heptane:ethyl acetate to give 2,6-dichloro-isonicotinic acid tert. -butyl ester (14.2 g) as a brownish oil which slowly solidifies; LC-MS: tR = 1.05 min; 1H NMR (D6-DMSO): £1.56 (s, 9 H), 7.85 (s, 2 H).

The synthetic route of 36805-97-7 has been constantly updated, and we look forward to future research findings.

Application of 446-59-3, A common heterocyclic compound, 446-59-3, name is 2-Bromo-1-fluoro-3-methoxybenzene, molecular formula is C7H6BrFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 1-40fluoro-phenol (1-40)To a solution of 2-bromo-3-fluoroanisole [C.A.S. 935285-66-8] (1 g, 4.48) in DCM (2 mL), BBr3 (17.93 mL, 17.93 mmol) was added dropwise at 0C. The reaction was stirred 2 h at r.t. Then the excess of BBr3 was quenched dropwise with water at 0C, the organic layer was separated, dried (Na2S04), filtered and the solvent evaporated in vacuo to yield intermediate 1-40 (0.94 g, quant, yield) that was used as such in the next reaction step

The synthetic route of 446-59-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 588-96-5, name is p-Bromophenetole, A new synthetic method of this compound is introduced below., name: p-Bromophenetole

(3) Dissolve 1 g of p-bromophenylethyl ether in 30 mL of 1,4-dioxane solution, add 1.2 equivalents of bis(pinacolato)diboron, 3 equivalents of potassium acetate, 5% equivalent of [1,1′-double (Diphenylphosphino)ferrocene]palladium dichloride was subjected to argon gas treatment at 80 C for 8 hours, and the product was obtained by column chromatography.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 95970-05-1, name is 2,6-Dibromo-4-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., category: ethers-buliding-blocks

A 250 mL round bottom flask equipped with a stir bar, Vigreux column and nitrogen inlet was charged with 2,6-dibromo-4-methoxy-phenylamine, (14 g, 50 mmol) and NMP, (80 mL). Copper cyanide, (18 g, 200 mmol) was then added at ambient temperature and the reaction was heated at 140 C oil bath temperature. The reaction was allowed left to stir for 24 h. The reaction was cooled, diluted with EtOAc, (1000 mL) and poured into 1000 mL of 10% ethylene diamine solution. The mixture was stirred vigorously for 2 h. The mixture was filtered through a pad of celite and washed with copious EtOAc (poor solubility) and the phases were split. The aqueous phase was extracted with EtOAc, (500 mL) (chi3), the combined EtOAc extracts were washed with water (500 mL), dried (Na2SO4), and the solvent was evaporated under reduced pressure. The material was passed through a pad of silica gel eluting with DCM-EtOAc (10% EtOAc). Amount obtained: 5.0 g, 29 mmol, 58% yield.

According to the analysis of related databases, 95970-05-1, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 92248-06-1, name is Bis(3-methoxyphenyl)amine, This compound has unique chemical properties. The synthetic route is as follows., category: ethers-buliding-blocks

To a solution of bis(3-methoxyphenyl)amine (1.15g, 5.00mmol) in THF (20mL) at RT was added sodium hydride (60% dispersion in mineral oil, 550mg, 13.8mmol). The suspension was heated to 75C and stirred for 30 min at this temperature. Iodomethane (0.716mL, 11.5mmol) was added within 5 min at 75C and the reaction mixture was continued to stir for 2 h at this temperature. The suspension was treated with water (20mL) and extracted with Et2O (3×65mL). The combined organic layer was dried over Na2SO4 and concentrated in vacuo. Column chromatography on silica gel with pentane:CH2Cl2 3:1 to 1:1 gave 3-methoxy-N-(3-methoxyphenyl)-N-methylaniline (1d) as a yellowish oil (979mg, 81%): Rf 0.64 (CH2Cl2 100%); numax (neat): 2938w, 2834w, 2338w, 1589s, 1489s, 1347w, 1279w, 1221m, 1169w, 1122w, 1046w, 766s, 708w, 631s; 1H NMR (500MHz, CDCl3) delta=7.15-7.19 (2H, m, C5H), 6.62 (2H, ddd, 3J 8.1, 4J 2.2, 0.8, C6H), 6.57-6.58 (2H, m, C2H), 6.52 (2H, ddd, 3J 8.2, 4J 2.5, 0.8, C4H), 3.76 (6H, s, OCH3), 3.29 (3H, s, NCH3); 13C NMR (125MHz, CDCl3) delta=160.5 (C3), 150.2 (C1), 129.8 (C5), 113.3 (C6), 106.7 (C4), 106.6 (C2), 55.2 (OCH3), 40.3 (NCH3); ESI-MS: m/z calcd. for C15H18NO2+ 244.1332 found 244.1330 [M+H+].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 92248-06-1.