In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59557-91-4, name is 4-Bromo-2-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 4-Bromo-2-methoxyaniline
At room temperature, concentrated sulfuric acid (185 mL) and deionized water (144 mL) were added with mechanical stirring in a three-necked flask.Glycerol (768.5 mmol, 207.5 g) was added and the temperature was lowered to room temperature. Sodium 3-nitrobenzenesulfonate (733 mmol, 165 g) was added in portions and the reaction was carried out at 80 C for 3 hours, 4-bromo-2-methoxyaniline (compound shown by the formula (I-1)) (495 mmol, 100.0 g) was added portionwise with vigorous stirring to giveHeat to 120 C and react overnight. Add water (600 mL) and adjust pH to approx. 7.0 with concentrated aqueous ammonia. Extract with water and ethyl acetateAfter the extraction, the organic phase was dried over anhydrous sodium sulfate, filtered, and the solvent was spinned to give 103 g of tan by column chromatographyThe oily product (compound represented by the formula (I)) had a yield of 87.4% and a purity of 94%.
The synthetic route of 59557-91-4 has been constantly updated, and we look forward to future research findings.