Reference of 36805-97-7,Some common heterocyclic compound, 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, molecular formula is C11H25NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2,6-Dichloro-isonicotinic acid (11.2 g, 57.1 mmol) is suspended in toluene (150 mL) at 800C and then treated with N,N-dimethylformamide di-tert.-butyl acetal (50 mL, 209 mmol).The dark mixture is stirred at 800C for 12 h, then at rt for 16 h. The dark solution is diluted with diethyl ether (400 mL), washed with sat. aq. NaHCO3 solution (3×100 mL), dried overNa2SO4, filtered and concentrated. The crude product is purified by MPLC on silica gel eluting with heptane:ethyl acetate to give 2,6-dichloro-isonicotinic acid tert. -butyl ester (14.2 g) as a brownish oil which slowly solidifies; LC-MS: tR = 1.05 min; 1H NMR (D6-DMSO): £1.56 (s, 9 H), 7.85 (s, 2 H).
The synthetic route of 36805-97-7 has been constantly updated, and we look forward to future research findings.