Electric Literature of 20781-20-8, These common heterocyclic compound, 20781-20-8, name is (2,4-Dimethoxyphenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of compound 58 (6.6 g, 33.5 mmol) in dichloromethane (100 mL)were added DIPEA (8.65 g, 67 mmol), HOBt (5.4 g, 36.85 mmol) and EDCI (9.6 g, 50.3mmol). After about 15 mm stirring, to the homogeneous reaction mixture was added asolution of 2,4-dimethoxybenzyl amine (5.6 g, 33.5 mmol) in dichloromethane (50 mL)dropwise under nitrogen atmosphere. The resulting mixture was stirred under nitrogenatmosphere at room temperature for 16h. The reaction mixture was washed successively with iN NaOH (100 mL), water (100 mL) and brine (100 mL). The organic phase was then dried over Na2SO4 and evaporated to give a crude solid product 59 that crystallized from ethyl ether. Filtration and open air suction drying afforded an off-white solid pureproduct 9.8g (96%), (MS: [M+1] = 347).
Statistics shows that (2,4-Dimethoxyphenyl)methanamine is playing an increasingly important role. we look forward to future research findings about 20781-20-8.