Tag: M.W=200-300

Reference of 262587-05-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 262587-05-3 as follows.

A nitrogen-purged mixture of tris(dibenzylideneacetone)dipalladium(0) (0.0193 g, 0.021 mmol), and di-tert-butyl(2′,4′,6′-triisopropyl-3,4,5,6-tetramethyl-[1,1′-biphenyl]-2-yl)phosphine (0.0251 g, 0.052 mmol) in toluene (2.2 mL) was stirred for 20 minutes and then added to an nitrogen-purged mixture of methyl 3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylate (0.1760 g, 0.441 mmol, E509), 1-bromo-3-(difluoromethoxy)benzene (0.1179 g, 0.529 mmol), and Cs2CO3 (0.2143 g, 0.658 mmol). The mixture was heated to 70 C overnight, diluted with water, extracted with DCM (3 x 8 mL), dried (Na2SO4), and concentrated. The residue was chromatographed on silica (30-60% EtOAc/DCM to 4% MeOH/DCM) and re-chromatographed (2.5-4% zPrOH/DCM) to give the titled compound. 1H NMR (400 MHz, DMSO-d6) delta ppm 8.28 – 8.16 (m, 2H), 7.58 (t, J = 8.2 Hz, 1H), 7.51 – 7.03 (m, 3H), 3.95 (dq, J = 18.1, 9.8, 8.5 Hz, 1H), 3.88 (s, 3H), 3.63 – 3.48 (m, 6H), 2.91 (t, J = 11.9 Hz, 2H), 2.53 – 2.48 (m, 4H), 2.46 – 2.28 (m, 2H), 2.12 – 1.88 (m, 4H), 1.63 (td, J = 13.1, 12.6, 6.4 Hz, 2H).

According to the analysis of related databases, 262587-05-3, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5467-58-3, name is 1-Bromo-4-methoxynaphthalene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Bromo-4-methoxynaphthalene

An excess of 1.6 M n-BuLi in hexane(162 ml, 258 mmol) was added to a solution of 1-bromo-4-methoxynaphthalene(50.9 g, 215 mmol) in 800 ml dry tetrahydrofuran at -78 C. under N2. The reaction mixture was then maintained at 0 C. for 1 h before cooling to -78 C. Trimethylborate(35 g, 335 mmol) was added dropwise; the solution was then warmed slowly to room temperature and stirred for 24 h. 2N HCl (250 ml)was added and then the mixture was stirred for a further 1 h. The reaction mixture was extracted with ethyl acetate and water, dried with anhydrous magnesium sulfate, the solvent was evaporated in vacuo, and the residue was crystallized(n-hexane) to give the 4-methoxynaphthalen-1-ylboronic acid (31.8 g, 157 mmol, 61%) as a white solids.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

These common heterocyclic compound, 5473-01-8, name is 2-Bromo-6-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 2-Bromo-6-methoxyaniline

To a cooled (in an ice bath) suspension of 6-bromo-2-anisidine (63.52 g, 0.314 mol) in concentrated hydrochloric acid (130 ml) was added dropwise a solution of sodium nitrite (22 g, 0.32 mol) in water (100 ml) while the temperature was kept below 5 °C. After stirring for a further 30 min at 4 °C the red solution of the diazo compound was filtered and to the filtrate the chilled solution of tin(II) chloride dihydrate (175 g, 0.78 mol) in concentrated hydrochloric acid (200 ml) was added dropwise while occasionally adding water (all together ca. 500 ml water were added), while hydrazine hexachlorostannane precipitated. The reaction mixture was allowed to warm to room temperature and stirred for 3 h, after which the product was filtered off, and washed with saturated brine once. The solid was dissolved by the careful addition to a chilled aqueous solution of 25percent sodium hydroxide (200 ml) containing ca. 40 g of potassium tartrate. The product was extracted with dichloromethane (4 .x. 50 ml). The combined organic layers were washed with 2 M NaOH and water, dried over MgSO4 and evaporated to give 59.4 g (87percent) of desired product as a tan solid. Mass spectrum, m/z (I rel., percent): 219 (9), 218 (95), 217(10), 216 (100), 203 (64), 201(74), 200 (83), 198 (80), 186 (39).

The synthetic route of 2-Bromo-6-methoxyaniline has been constantly updated, and we look forward to future research findings.

Related Products of 204452-91-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 204452-91-5 name is 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The compound (12 g, 57.6 mmol) prepared in the above step 2 was dissolved in acetonitrile (192 ml), and N-bromosuccinimide (NBS) (10.77 g, 60.5 mmol) was slowly added at room temperature. After the reaction mixture was stirred at room temperature for 30 minutes, And concentrated under reduced pressure. After extracting the reaction residue obtained from the above with diethyl ether and ice water, The organic layer was washed with brine, dried over sodium sulfate, concentrated under reduced pressure, and purified by MPLC to obtain yellow To give the desired compound (11 g, 66%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine, and friends who are interested can also refer to it.

Related Products of 120-11-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120-11-6, name is 1-(Benzyloxy)-2-methoxy-4-(prop-1-en-1-yl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The mixture of the substrate (0.250 mmol), 0.5% Pd/MS3A or 0.5% Pd/MS5A (10 wt % of the substrate) and MeOH (1 mL) was stirred under H2 atmosphere (balloon) at room temperature. After a given period, the reaction mixture was filtered through a membrane filter (Millipore, Millex-LH, 0.45 mm), and the filtrate was concentrated in vacuo to produce the corresponding reduced product.

The synthetic route of 1-(Benzyloxy)-2-methoxy-4-(prop-1-en-1-yl)benzene has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 944317-92-4, name is 1-Bromo-4-fluoro-5-isopropyl-2-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 944317-92-4, SDS of cas: 944317-92-4

lOg (0.0405 mol) product 4, 11.05g(0.04455 mol) 2-methoxycarbonyl-4- trifiuromethylphenylboronic acid, 2.45g tetra-(triphenylphosphine) palladium, 16g anhydrous potassium carbonate and 100 ml tetrahydrofuran were added into a 250 mL 3-neck fiaskto form a suspension. The mixture was heated to reflux overnight, then cooled to room temperature, filtered, poured into 300 mL water, and was extracted by 3><300 mL ethyl acetate. The organic phase was washed by saturated NaCl solution, dried by anhydrous Na2S04 and distilled under vacuum to obtain a yellow solid. Recrystallization in ethyl acetate gave 7.82g of product 5. If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 888327-32-0, name is 4-Bromo-1-(difluoromethoxy)-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Bromo-1-(difluoromethoxy)-2-methylbenzene

l-(4-Difluoromethoxy-3-methyl-phenyl)-cis-3,5-dimethyl-piperazine:; To 4-bromo-l- (difluoromethoxy)-2-methylbenzene (2.36 g, 10.00 mmol) in toluene (50 mL) was added cis-2,6- dimethylpiperazine (5 g, 58.14 mmol), Pd(OAc)2 (120 mg, 0.53 mmol), BINAP (380 mg, 0.61 mmol), and t-BuOK (2.2 g, 19.64 mmol). The resulting solution was stirred for 4 hours at 80C. The solution was cooled to room temperature and washed with H2O (2 X 50 mL), dried over Na2SCt, concentrated, and purified by silica gel column chromatography (10:1 CH2CWMeOH) to give 1.1 g (41%) of l-(4- (difluoromethoxy)-3-methylphenyl)-3,5-dimethylpiperazine.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 888327-32-0.

Reference of 24878-25-9,Some common heterocyclic compound, 24878-25-9, name is 2,2′-Oxydianiline, molecular formula is C12H12N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of [Pt(MeCN)2Cl2] in hot acetonitrile (80 C) the corresponding L1 or L2 ligand was added; the reaction mixture was stirred for 72 h in the case of 2, and 24 h for 5. Then, the solution was cooled to room temperature and the solid obtained was filtered by suction.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,2′-Oxydianiline, its application will become more common.

295376-21-5, name is 1-Bromo-2-fluoro-3-methoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 1-Bromo-2-fluoro-3-methoxybenzene

A 250ml three-necked flask was charged with 5 g (24.4 mmol) of 2-fluoro-3-methoxy-bromobenzene,13.5 g (103.74 mmol) of ethyl acetoacetate,55ml of dimethyl sulfoxide,L-proline 1.12 g (9.76 mmol),930 mg (4.88 mmol) of cuprous iodide,Under the protection of nitrogen, 32 g (97.6 mmol) of cesium carbonate was added, and the reaction was kept at 60 to 70 C for 4 to 5 hours.Stop the reaction, add 40 ml of saturated ammonium chloride solution, stir to dissolve, add 40 ml * 2 ethyl acetate for extraction, combine the ethyl acetate layers, wash the layers with saturated brine, and perform column chromatography (mobile phase ethyl acetate: petroleum ether = 1:15)5.4 g (21.3 mmol) of compound I was obtained as a pale yellow oil with a yield of 87.2%.

The synthetic route of 295376-21-5 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4698-11-7, name is 10-Methoxy-5H-dibenzo[b,f]azepine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4698-11-7

Following the procedure of Example 1, but using 30% aqueous formic acid instead of the same volume of 10% aqueous sulfuric acid, the yield is 58.0 (76.6% on theoretical).

The synthetic route of 4698-11-7 has been constantly updated, and we look forward to future research findings.