Analyzing the synthesis route of 4-Bromo-1-(difluoromethoxy)-2-methylbenzene

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 888327-32-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 888327-32-0, name is 4-Bromo-1-(difluoromethoxy)-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Bromo-1-(difluoromethoxy)-2-methylbenzene

l-(4-Difluoromethoxy-3-methyl-phenyl)-cis-3,5-dimethyl-piperazine:; To 4-bromo-l- (difluoromethoxy)-2-methylbenzene (2.36 g, 10.00 mmol) in toluene (50 mL) was added cis-2,6- dimethylpiperazine (5 g, 58.14 mmol), Pd(OAc)2 (120 mg, 0.53 mmol), BINAP (380 mg, 0.61 mmol), and t-BuOK (2.2 g, 19.64 mmol). The resulting solution was stirred for 4 hours at 80C. The solution was cooled to room temperature and washed with H2O (2 X 50 mL), dried over Na2SCt, concentrated, and purified by silica gel column chromatography (10:1 CH2CWMeOH) to give 1.1 g (41%) of l-(4- (difluoromethoxy)-3-methylphenyl)-3,5-dimethylpiperazine.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 888327-32-0.