Related Products of 204452-91-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 204452-91-5 name is 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The compound (12 g, 57.6 mmol) prepared in the above step 2 was dissolved in acetonitrile (192 ml), and N-bromosuccinimide (NBS) (10.77 g, 60.5 mmol) was slowly added at room temperature. After the reaction mixture was stirred at room temperature for 30 minutes, And concentrated under reduced pressure. After extracting the reaction residue obtained from the above with diethyl ether and ice water, The organic layer was washed with brine, dried over sodium sulfate, concentrated under reduced pressure, and purified by MPLC to obtain yellow To give the desired compound (11 g, 66%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine, and friends who are interested can also refer to it.