Month: March 2021

Electric Literature of 22236-10-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22236-10-8, name is 4-(Difluoromethoxy)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 4-CHLORO-2-METHYL-QUINAZOLINE (450 mg, 2.52 mmol), 4- difluoromethoxy-phenylamine (0.32 ml, 2.52 mmol) and sodium acetate (248.07 mg, 3.02 mmol) in 6 mL of solvent (THF: water = 1 : 1) was stirred at 70 C for 1 h. The reaction mixture was diluted with 30 mL of ethyl acetate. It was washed with brine, dried over anhydrous NA2S04, filtered and concentrated. The crude product was purified by chromatography on silica gel with acetate and hexane (1: 5) as eluent, yielding 713 mg of title compound (94 %). H NMR (CDC13) : 7.87-7. 76 (m, 5H), 7.51 (t, J = 8.4 Hz, 1H)), 7.40 (brs, 1H), 7.19 (d, J = 8.7 Hz, 2H), 6.76-6. 27 (three single peaks, 1H), 2.71 (s, 3H).

The synthetic route of 4-(Difluoromethoxy)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MYRIAD GENETICS, INC.; CYTOVIA, INC.; WO2005/3100; (2005); A2;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 854391-95-0 as follows. Recommanded Product: Bis(4-methoxybenzyl)amine hydrochloride

A solution of benzaldehyde (1.00 g, 9.42 mmol)and benzylamine (1.01 g, 9.42 mmol) in PhMe (120 mL) was heated under reflux inan inert atmosphere with stirring for 16 hours. The H2O generatedwas collected in a Dean-Stark trap. The solvent was removed under vacuum andthe pale yellow oil obtained was dissolved in MeOH (60 mL) before NaBH4(2.1 g, 56.5 mmol) was added. The resulting solution was stirred overnight atroom temperature in an inert atmosphere. The reaction mixture was then treatedwith HCl (2 M, 10 mL), and the solvents were removed under reduced pressure.The solid residue was suspended in NaOH (8 M, 30 mL) and extracted with CHCl3(3 x 60 mL). The combined organic fractions were dried (MgSO4),filtered and the solvents were evaporated off to give I as a pale yellow oil. White crystalline solid (25 %). 1HNMR (300 MHz, CD3CN) d =7.40 (d, 4H), 7.00 (d, 4H), 4.12 (s, 4H), 3.70 (s, 6H).

According to the analysis of related databases, 854391-95-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Payne, Nicholas A.; Delmas, Luke C.; McDowell, Sean A.C.; Williams, Avril R.; Tetrahedron Letters; vol. 56; 37; (2015); p. 5175 – 5179;,
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Related Products of 910251-11-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[008691 Step E: Preparation of 2-(tert-butyl)-5-(methoxymethyl)benzonitrile: Charged a thick walled glass pressure vessel with 5-bromo-2-(tert-butyl)benzonitrile (520 mg, 2.18 mmol), dicyclohexyl(2?,6?-dimethoxy- [1,1 ?-biphenyl]-2-yl)phosphine (?S-Phos?) (179 mg, 0.437 mmol), Pd(OAc)2 (49.0 mg, 0.218 mmol), potassium (methoxymethyl)trifluoroborate (664 mg, 4.37 mmol), Cs2CO3 (2.8 g, 8.7 mmol), and 1:1 dioxane/water (10 mL). Sparged with N2 for several minutes, then heated to 100 C overnight with stirring. After cooling to ambient temperature, partioned mixture between EtOAc (20 mL) and water (20 mL). Separated phases, re-extracting aqueous with EtOAc (10 mL). Combined organics were washed with brine (20 mL), dried (MgSO4), filtered, and concentrated. The crude material was purified by Biotage Flash 40 silica gel column, eluting with a gradient of 5%-10% EtOAc/hexanes. Yield: 187 mg (36%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Potassium trifluoro(methoxymethyl)borate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARRAY BIOPHARMA INC.; BLAKE, James F.; BRANDHUBER, Barbara J.; HAAS, Julia; NEWHOUSE, Brad; THOMAS, Allen A.; WINSKI, Shannon L.; WO2014/78331; (2014); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36449-75-9, name is 1-(2-Bromoethyl)-2-methoxybenzene, A new synthetic method of this compound is introduced below., Product Details of 36449-75-9

General procedure: To a DMF solution (3 mL) of bromide derivative, were added sodium iodide (0.05 eq) and sodium azide (1.2 eq) at 40 C. The reaction mixture was stirred for overnight. Et2O (20 mL) was added to the mixture then the organic layer was washed with water (3 ¡Á 20 mL), dried over MgSO4 and concentrated under reduced pressure to give the azide derivative. Spectroscopic data of compounds are identical to those previously reported [10].

The synthetic route of 36449-75-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Menendez, Christophe; Chollet, Aurelien; Rodriguez, Frederic; Inard, Cyril; Pasca, Maria Rosalia; Lherbet, Christian; Baltas, Michel; European Journal of Medicinal Chemistry; vol. 52; (2012); p. 275 – 283;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 104-92-7, name is 1-Bromo-4-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Bromo-4-methoxybenzene

Pd(OAc)2/2-Catalyzed Amination of Aryl and Heteroaryl Bromides (Table 3).General Procedure: An oven-dried Schlenk flask equipped with a magnetic stirring bar was charged with Pd(OAc)2 (x mol %, see Table 3) and NaO-t-Bu (1.5 mmol). Amine (1.2 mmol) and aryl bromide (1.0 mmol) were also added at this time, if they were solids. The flask was capped with a rubber septum, evacuated and then flushed with argon. This cycle was repeated three times. Ligand 2 (2x mol %, see Table 3) was then added via syringe from a stock solution. Aryl bromide (if a liquid, 1.0 mmol), amine (if a liquid, 1.2 mmol) and toluene (3 mL) were then successively added by syringe. The reaction mixture was heated at the temperature indicated in Table 3 until the starting material had been completely consumed as judged by TLC (15-20 hours). The mixture was then cooled to room temperature, adsorbed onto silica gel and then purified by column chromatography (hexanes/ethyl acetate as eluent).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 104-92-7.

Reference:
Patent; Iowa State University Research Foundation, Inc.; US7385058; (2008); B1;,
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Application of 7252-83-7, The chemical industry reduces the impact on the environment during synthesis 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, I believe this compound will play a more active role in future production and life.

(1R,2S) and (1S,2R)-2-(4-chlorophenyl)-1′-(2,2-dimethoxyethyl)spiro[cyclopropane-1,3′-indolin]-2′-one To a solution of (1R,2S) and (1S,2R)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one (135 mg, 1 mmol) in DMF (1 mL) was added KHMDS (0.5 M in THF, 1.1 mL) was dropwise at room temperature. The mixture was stirred for half an hour before adding bromoacetaldehyde dimethyl acetal (95 mg, 0.55 mmol). The mixture was warmed to 50 C. and stirred at that temperature for 2 hours. The mixture was poured into water, extracted with ethyl acetate (3¡Á15 mL), dried and concentrated under reduced pressure. Purification by flash column chromatography on silica gel, eluting with hexanes-EtOAc (6:1 and then 4:1) gave the desire product as colorless oil (268 mg, 75%). LC/MS m/e calcd. for C20H20ClNO3: 3570, observed (M+H)+: 358.7.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1,1-dimethoxyethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chen, Li; Feng, Lichun; He, Yun; Huang, Mengwei; Yun, Hongying; US2011/144106; (2011); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6346-09-4, name is 4,4-Diethoxybutan-1-amine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4,4-Diethoxybutan-1-amine

To 1.0 g 2-chloropyrimidine (8.73 mmol) dissolved in30 cm3 of dry acetonitrile 1.40 g 4,4-diethoxybutyl-1-amine (8.73 mmol) and 1.50 g K2CO3 were added. Themixture was refluxed for 36 h. Precipitate was filtered offand solvent was evaporated under reduced pressure.Resulting residue was dried in vacuo (3 h, 1333 Pa) toafford 1.69 g (81 %) 1 as yellow oil. 1H NMR (400 MHzCDCl3): d = 1.18 (t, J = 7.1 Hz, 6H, CH3), 1.64-1.72 (m,4H, CH2), 3.40-3.52 (m, 4H, NCH2, OCH2), 3.58-3.67 (m,2H, OCH2), 4.50 (t, J = 5.5 Hz, 1H, CH), 5.68-5.78 (br.m, 1H, NH), 6.48 (t, J = 4.8 Hz, 1H, CHPyr), 8.24 (d,J = 4.8 Hz, 2H, CHPyr) ppm; 13C NMR (150 MHz,CDCl3): d = 15.7 (CH3), 25.2 (CH2), 31.5 (CH2), 41.6(CH2-N), 61.6 (CH2-O), 103.1 (CH), 110.6 (CHAr), 158.3(CHAr), 162.9 (CAr) ppm; IR (Nujol): v = 781, 803, 990,1062, 1128, 1269, 1371, 1414, 1456, 1535, 1593, 2876,2931, 2975, 3108, 3140, 3276 cm-1

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6346-09-4.

Reference:
Article; Gazizov, Almir S.; Kharitonova, Natalya I.; Smolobochkin, Andrey V.; Syakaev, Viktor V.; Burilov, Alexander R.; Pudovik, Michail A.; Monatshefte fur Chemie; vol. 146; 11; (2015); p. 1845 – 1849;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 651734-54-2, name is 2,6-Difluoro-3,5-dimethoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2,6-Difluoro-3,5-dimethoxyaniline

a) 5-[2,6-Difluoro-3,5-dimethoxy-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-ylamine A mixture of 4-Amino-2-methylsulfanyl-pyrimidine-5-carbaldehyde (2.45 g, 14.5 mmol), 2,6-difluoro-3,5-dimethoxyaniline (2.75 g, 14.5 mmol), and camphorsulfonic acid (1.01 g, 4.35 mmol) in toluene (80 ML) was heated at reflux for 18 hours (note: the flask was equipped with a Dean-Stark trap).The solvent was removed under reduced pressure to afford a yellow solid.The crude product was sufficiently pure, so it was taken on to the next step.To a suspension of the crude imine (~4.93 g) in tetrahydrofuran (60 ML) at 0 C., lithium aluminum hydride (820 mg, 21.6 mmol) was added in several portions.Caution, gas evolution! The resulting yellow suspension was then stirred at 0C. for 1 hour, whereupon a green solution was afforded.water (1 ML), 15% aqueous sodium hydroxide (1 ML), and water (3 ML) were added sequentially.Care is advised during this quenching protocol.The resulting mixture was then stirred at 0 C. for 10 minutes.The suspension was then filtered over a pad of Celite, and the Celite was rinsed with dichloromethane.The combined filtrates were concentrated under reduced to give a thick oil.Recrystallization was accomplished with a solvent mixture of dichloro-methane:hexanes:methanol (17:8.5:1, 312 ML) to give 1.85 g of the desired aniline.The mother liquor was concentrated and recrystallized with the same solvent mixture to give an additional 0.48 g of product.The second mother liquor was concentrated and recrystallized to afford 0.84 g.The precipitates were combined to give 3.17 g (64%, for 2 steps) of the title compound: MS (APCI) 343.1, 344.1.

According to the analysis of related databases, 651734-54-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chivikas Connolly, Cleo J.; Deur, Christopher James; Hamby, James Marino; Hoyer, Denton Wade; Limberakis, Chris; Reed, Jessica Elizabeth; Schroeder, Mel Conrad; Taylor, Clarke; US2004/19210; (2004); A1;,
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Related Products of 20265-97-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20265-97-8, name is 4-Methoxyaniline hydrochloride belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

N-Acetyl-p-anisidine (3u).[17] p-Anisidine hydrochloride (0.80 g, 0.0050 mol) and trimethyl orthoacetate (0.66 g, 0.0055 mol were combined in a 10 mL round bottomed flask and heated under gentle reflux while being stirred for 1 hours. The homogeneous solution was then evaporated under reduced pressure to yield crude product that was crystallized from H2O/EtOH affording colorless plates (78%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methoxyaniline hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Di Grandi, Martin J.; Bennett, Caitlin; Cagino, Kristen; Muccini, Arnold; Suraci, Corey; Saba, Shahrokh; Synthetic Communications; vol. 45; 22; (2015); p. 2601 – 2607;,
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Application of 24743-14-4, The chemical industry reduces the impact on the environment during synthesis 24743-14-4, name is 3-(3-Methoxyphenyl)-1-propene, I believe this compound will play a more active role in future production and life.

Dihydroxylation of compound 36 (1.5 g, 10.1 mmol) with OsO4 followed the same method as adopted for 2 and the crude product 39 (1.73 g, 9.73 mmol, 91%) was used for the next step. mp 90-92 C. 1H NMR (400 MHz, CDCl3, delta): 7.22 (t, J = 7.7 Hz, 1H), 6.79 (m, 3H), 3.93 (m, 1H), 3.79 (s, 3H), 3.67 (m, 1H), 3.50 (m, 1H), 2.73 (m, 2H), 2.32 (m, 2H). 13C NMR (100.6 MHz, CDCl3, delta): 159.8, 139.3, 129.7, 121.6, 115.6, 115.1, 111.9, 72.9, 66.1, 55.2, 39.9. IR (neat): 3391, 2939, 2836, 1602, 1585, 1489, 1455, 1437, 1259, 1153, 1092, 1038, 781, 697 cm-1. EIMS (70 eV) m/z: 182.0 (M+, 27.6), 151.0 (21.2), 122.0 (100), 121.0 (44.8), 107.0 (24.7), 91.0 (11.8), 77.0 (20.7). HRMS-EI (m/z): M+ calcd for C10H14O3, 182.0943; found 182.0948.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(3-Methoxyphenyl)-1-propene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tripathi, Subhankar; Chan, Ming-Huan; Chen, Chinpiao; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 216 – 221;,
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