In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 854391-95-0 as follows. Recommanded Product: Bis(4-methoxybenzyl)amine hydrochloride
A solution of benzaldehyde (1.00 g, 9.42 mmol)and benzylamine (1.01 g, 9.42 mmol) in PhMe (120 mL) was heated under reflux inan inert atmosphere with stirring for 16 hours. The H2O generatedwas collected in a Dean-Stark trap. The solvent was removed under vacuum andthe pale yellow oil obtained was dissolved in MeOH (60 mL) before NaBH4(2.1 g, 56.5 mmol) was added. The resulting solution was stirred overnight atroom temperature in an inert atmosphere. The reaction mixture was then treatedwith HCl (2 M, 10 mL), and the solvents were removed under reduced pressure.The solid residue was suspended in NaOH (8 M, 30 mL) and extracted with CHCl3(3 x 60 mL). The combined organic fractions were dried (MgSO4),filtered and the solvents were evaporated off to give I as a pale yellow oil. White crystalline solid (25 %). 1HNMR (300 MHz, CD3CN) d =7.40 (d, 4H), 7.00 (d, 4H), 4.12 (s, 4H), 3.70 (s, 6H).
According to the analysis of related databases, 854391-95-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Payne, Nicholas A.; Delmas, Luke C.; McDowell, Sean A.C.; Williams, Avril R.; Tetrahedron Letters; vol. 56; 37; (2015); p. 5175 – 5179;,
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