Month: October 2022

Xi, Xudong; Yin, Hongfang; Jin, Xiaojun; He, You published the artcile< Extraction of Notopterygium forbesii by supercritical CO2 extraction>, Quality Control of 52244-70-9, the main research area is Notopterygium supercritical carbon dioxide extraction.

The extracting process for Notopterygium forbesii by supercritical CO2 extraction was optimized. The best conditions of the extracting essential oil from root of Notopterygium forbesii by SFE-CO2 were studied and chem. composition was determined by using the GC-MS. The optimum process was as following: the temperature of extracting technique was 50°, pressure 25 MPa, extraction time 2 h and gas flow rate 65 kg/h-1. The extracting rate of essential oil was 8.8%, about 6 times to steam distillation And 159 kinds of compound was identified from extracting essential oil, furthermore compound containing Cl, S, B, F, the Si element had not been reported in the related literature. Temperature and pressure were the key factors which affected extracting efficiency and stability of Notopterygium forbesii by supercritical CO2 extraction

Yaowu Fenxi Zazhi published new progress about Essential oils Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Antuganov, Dmitrii; Zykov, Michail; Timofeev, Vasilii; Timofeeva, Ksenija; Antuganova, Yulija; Orlovskaya, Victoriya; Fedorova, Olga; Krasikova, Raisa published the artcile< Copper-Mediated Radiofluorination of Aryl Pinacolboronate Esters: A Straightforward Protocol by Using Pyridinium Sulfonates>, Electric Literature of 190788-60-4, the main research area is aryl pinacolboronate ester radiofluorination copper pyridinium sulfonate catalyst base.

Radiofluorination of arylboronic acids pinacol esters (arylBPin) mediated by copper triflate pyridine complex is one of the more promising synthetic approaches for the direct introduction of nucleophilic [18F]fluoride into non-activated arenes and heteroarenes. However, the application of this method to the production of positron emission tomog. (PET) radiotracers in automated synthesizers remains a challenging task. The choice of phase-transfer catalyst (PTC) and corresponding base used for the generation of reactive [18F]fluoride species has a profound impact on the efficiency of the 18F-fluorination process. Herein the authors report the development of a simple procedure involving trapping of the aqueous [18F]fluoride on a weak anion-exchange resin (WAX) and its release by elution with pyridinium sulfonate in di-Me acetamide. Obtained reactive [18F]fluoride was used as-is in a copper-catalyzed fluorination reaction employing pyridinium salt as both PTC and base. High radiochem. conversion rates (RCCs) achieved for a series of simple arylBPin substrates and 4-[18F]fluoro-D,L-phenylalanine demonstrate the efficiency of this novel 18F-processing approach. Notably, the proposed method obviates conventional azeotropic drying steps, solvents evaporation and/or changeover and can be implemented on com. automated synthesizers.

European Journal of Organic Chemistry published new progress about Esters Role: RCT (Reactant), RACT (Reactant or Reagent) (Aryl Pinacolboronate Esters). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Electric Literature of 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dupuy, Stephanie; Zhang, Ke-Feng; Goutierre, Anne-Sophie; Baudoin, Olivier published the artcile< Terminal-Selective Functionalization of Alkyl Chains by Regioconvergent Cross-Coupling>, Formula: C11H16O2, the main research area is aryl triflate alkyl bromide palladium zinc Barbier Negishi coupling; alkyl linear arene preparation; C−C coupling; alkyl bromides; homogeneous catalysis; palladium; remote functionalization.

Hydrocarbons are still the most important precursors of functionalized organic mols., which has stirred interest in the discovery of new C-H bond functionalization methods. We describe herein a new step-economical approach that enables C-C bonds to be constructed at the terminal position of linear alkanes. First, we show that secondary alkyl bromides can undergo in situ conversion into alkyl zinc bromides and regioconvergent Negishi coupling with aryl or alkenyl triflates. The use of a suitable phosphine ligand favoring Pd migration enabled the selective formation of the linear cross-coupling product. Subsequently, mixtures of secondary alkyl bromides were prepared from linear alkanes by standard bromination, and regioconvergent cross-coupling then provided access to the corresponding linear arylation product in only two steps.

Angewandte Chemie, International Edition published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Landge, Shashikant B.; Dahale, Sunil B.; Jadhav, Sanjay A.; Solanki, Pavankumar V.; Bembalkar, Saroj R.; Mathad, Vijayavitthal T. published the artcile< Development and validation of stability indicating rapid RP-LC method for determination of process and degradation related impurities of apremilast, an anti-inflammatory drug>, COA of Formula: C12H19NO4S, the main research area is RPLC degradation apremilast antiinflammatory drug.

A new, specific, rapid and stability indicating reversed phase liquid chromatog. (RP-LC) method for the determination of process related and degradation related impurities of Apremilast has been developed and validated. The degradation study performed in acid, base, oxidative, photolytic, and thermal stressed conditions. Eight process related impurities (Imp-1 to Imp-8) in test sample of Apremilast have been detected by developed RP-LC method. The good chromatog. resolution between the peaks of process related impurities, degradation impurities and Apremilast has been achieved on a Synergi Max-RP 80 A (150 × 4.6 mm ID), 4μ column. The process and degradation related impurities were characterized by mass spectrometry, 1 H NMR and FT-IR spectral data. The method was validated as per ICH guideline and found to be specific, rapid, and stability indicating. The proposed RP-PLC method was successfully applied to the anal. of drug substance samples of Apremilast.

American Journal of Analytical Chemistry published new progress about Anti-inflammatory agents. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, COA of Formula: C12H19NO4S.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Fanourakis, Alexander; Williams, Benjamin D.; Paterson, Kieran J.; Phipps, Robert J. published the artcile< Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation>, Product Details of C11H16O2, the main research area is heptafluorobutyl hydroxy butyl sulfamate preparation enantioselective; arylbutanol heptafluorobutyl sulfamate intermol amination rhodium catalyst.

A family of anionic variants of the best-in-class catalyst for Rh-catalyzed C-H amination, Rh2(esp)2, with which the chiral cations are associated And derived from quaternized cinchona alkaloids, has been described. These ion-paired catalysts enable high levels of enantioselectivity to be achieved in the benzylic C-H amination of substrates R(CH2)4OH (R = Ph, 1-naphthyl, 3-methylthiophen-2-yl, etc.) bearing pentyl hydroxyl groups. Addnl., the quinoline of the chiral cation appears to engage in axial ligation to the rhodium complex, providing improved yields of products RCH(NHS(O)2OCH2R1)(CH2)3OH (R1 = (CF2)2CF3) vs. Rh2(esp)2 and highlighting the dual role that the cation is playing. These results underline the potential of using chiral cations to control enantioselectivity in challenging transition-metal-catalyzed transformations.

Journal of the American Chemical Society published new progress about Amination catalysts (intermol., stereoselective). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tang, Huiling; Liu, Mengna; Zhu, Meiqi; Cui, Benqiang; Shi, Yanhui; Cao, Changsheng published the artcile< C(sp2)-C(sp2) Suzuki cross-coupling of arylammonium salts catalyzed by a stable Pd-NHC complex>, SDS of cas: 190788-60-4, the main research area is phenylnaphthalene preparation; arylammonium salt phenylboronic acid Suzuki cross coupling palladium catalyst.

The authors developed the Suzuki-Miyaura cross-coupling of aryl ammonium salts via C-N bond activation catalyzed by an easily prepared and bench-stable palladium-N-heterocyclic carbene complex. The reaction proceeded well under mild conditions with phenylboronic acid and pinacol ester or anhydride and provided biaryls Ar1-Ar2 [Ar1 = 1-naphthyl, Ph, 2-pyridyl, etc., Ar2 = Ph, 4-MeC6H4, 4-PhC6H4, etc.] in up to 97% yield with good functional group compatibility. The direct arylation of arylamine could be performed by a two-step, one-pot process and a protocol could be performed on the gram scale.

Tetrahedron published new progress about Biaryls Role: SPN (Synthetic Preparation), PREP (Preparation). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, SDS of cas: 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Jinhui; Cao, Jilei; Wu, Xiangyang; Wang, Han; Yang, Xiaona; Tang, Xinxin; Toh, Ren Wei; Zhou, Rong; Yeow, Edwin K. L.; Wu, Jie published the artcile< Unveiling Extreme Photoreduction Potentials of Donor-Acceptor Cyanoarenes to Access Aryl Radicals from Aryl Chlorides>, Product Details of C13H19BO3, the main research area is aryl chloride boronate light cyanoarene photoreductive borylation catalyst; arylboronate preparation; phosphine aryl chloride light cyanoarene phosphorylation catalyst; arylphosphonium salt preparation.

Since the seminal work of Zhang in 2016, donor-acceptor cyanoarene-based fluorophores, such as 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN), have been widely applied in photoredox catalysis and used as excellent metal-free alternatives to noble metal Ir- and Ru-based photocatalysts. However, all the reported photoredox reactions involving this chromophore family are based on harnessing the energy from a single visible light photon, with a limited range of redox potentials from -1.92 to +1.79 V vs SCE. Here, we document the unprecedented discovery that this family of fluorophores can undergo consecutive photoinduced electron transfer (ConPET) to achieve very high reduction potentials. One of the newly synthesized catalysts, 2,4,5-tri(9H-carbazol-9-yl)-6-(ethyl(phenyl)amino)isophthalonitrile (3CzEPAIPN), possesses a long-lived (12.95 ns) excited radical anion form, 3CzEPAIPN•-*, which can be used to activate reductively recalcitrant aryl chlorides (Ered ≈ -1.9 to -2.9 V vs SCE) under mild conditions. The resultant aryl radicals can be engaged in synthetically valuable aromatic C-B, C-P, and C-C bond formation to furnish arylboronates, arylphosphonium salts, arylphosphonates, and spirocyclic cyclohexadienes.

Journal of the American Chemical Society published new progress about Aromatic nitriles Role: CAT (Catalyst Use), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Product Details of C13H19BO3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem